トリオレイン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H225：引火性の高い液体および蒸気

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

トリオレイン 価格

トリオレイン 化学特性,用途語,生産方法

• 外観

  無色～うすい黄色, 澄明の液体

• 定義

  本品は、オレイン酸(*)とグリセリン(*)のトリエステルであり、次の化学式で表される。
  参照表示名称：オレイン酸, グリセリン

• 溶解性

  水に不溶, エタノールに微溶, エーテルに可溶。エタノールにわずかに溶け、水にほとんど溶けない。

• 解説

  トリオレイン,無味無臭で無色の油状液．－6 ℃ で固化する．沸点235～240 ℃(2.4 kPa)．d⁵⁰40.8992．n⁶⁰_D1.4561．水に不溶，エタノールに難溶，有機溶媒に可溶．
  森北出版「化学辞典（第2版）

• 用途

  乳化剤。

• 化粧品の成分用途

  エモリエント剤、閉塞剤、非水系増粘剤、皮膚コンディショニング剤、皮膚保護剤

• 製造

  トリオレイン,オレイン酸グリセリンエステルの総称．不乾性油，バター脂などに存在する．その二重結合を異性化させるとエライジン(トランス形)となる．グリセリンと過剰のオレイン酸を加熱すると得られる．

• 使用上の注意

  不活性ガス封入

• 説明

  1,2,3-Trioleoyl glycerol is a triacylglycerol that contains oleic acid (Item Nos. 90260 | 24659) at the sn-1, sn-2, and sn-3 positions. It inhibits oxidized LDL-induced decreases in cell viability and superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities and increases in apoptosis in endothelial cells when used at a concentration of 10 μM. 1,2,3-Trioleoyl glycerol has been found in sunflower, corn, and extra virgin olive oils. It has been used as a standard for the quantification of triacylglycerols in extra virgin olive oil by high temperature gas chromatography-(ionic trap)mass spectrometry (HTGC-(IT)MS). 1,2,3-Trioleoyl glycerol is a major component of Lorenzo''s oil.

• 化学的特性

  Triolein occurs as a clear, colorless to yellowish oily liquid, and is tasteless and odorless.

• 使用

  Glycerol trioleate can be used as an emulsifier, also as creams, lotions and lipsticks matrix. Used as textile finishing agent in textile industry, also used as additive in pigment grind. In pharm industry, used as ointment, emulsifiable paste, suppository, lotion, emulsifier in air agent, stabilizing agent, lubricating agent, antifoaming agents. In food industry, it has the function as emulsify, disperse, defoaming, blister, antistaling of starch and control fat agglutination, usually used as agent in candy, ice cream, cookie and bread. When used in beverage, could avoid ester to float, and avoid protein to sink, therefore to improve stability. When used in bread, cookie , could improve organization structure, increase volume, antistaling, prolong warranty validity.

• 定義

  ChEBI: A triglyceride formed by esterification of the three hydroxy groups of glycerol with oleic acid. Triolein is one of the two components of Lorenzo's oil.

• 調製方法

  Triolein is manufactured by the esterification of fractionated fatty acids, mainly oleic acid and glycerin.

• 一般的な説明

  Glyceryl trioleate is derived from glycerol. It is composed of three oleic acid units and is an unsaturated triglyceride.

• 応用例（製薬）

  Triolein is used as a solubilizer and solvent in injectable preparations. It has been used in marketed preparations of sustained-release injections of cytarabine and multivesicular liposomal injections of morphine sulfate. It has also been used in enteric coatings for oral preparations in combination with other enteric coating excipients to protect against degradation by pancreatic lipase.
  Triolen is used in personal care products as a skin-conditioning and viscosity-controlling agent.

• 安全性

  Triolein is used in injectable preparations, in enteric coatings for oral preparations, and in personal care products. Chronic exposure may cause nausea and vomiting, and higher exposures may cause unconsciousness.
  The Cosmetic Ingredient Review (CIR) Expert Panel found that dermal application of triolein was not associated with significant irritation, and no evidence of sensitization or photosensitization was observed. Ocular exposures were found to be only mildly irritating to eyes. Triolein has not been found to be genotoxic in a number of in vitro and in vitro assay systems. Subcutaneous injections of triolein in rats showed no tumors at the injection site. The CIR Expert Panel also noted that metabolism data indicated that glyceryl triesters (including triolein) followed the same metabolic pathways as fats in food. They were split into monoglycerides, free fatty acids, and glycerol, all of which were absorbed into the intestinal mucosa and metabolized further. Therefore, oral exposure to these compounds was not found to be a concern.
  A triolein-based amphotericin emulsion showed better safety with a higher LD50 in rats as compared with the conventional amphotericin deoxycholate.

• 貯蔵

  Triolein is classified as a stable compound but is sensitive to air and light. It should be stored in tightly sealed containers in a dry area at 2–8℃. Thermal decomposition of triolein may lead to release of irritating gases and vapors such as carbon oxides. Exposure to air and moisture over prolonged periods should be avoided.

• 不和合性

  Triolein is incompatible with strong oxidizing agents and spontaneously flammable products. Being a triglyceride ester, triolein can be hydrolyzed by strong acids, and particularly by strong bases. It is possible for primary amines to form an adduct across the olefinic double bonds (analogous to a Michael addition).

• 規制状況(Regulatory Status)

  Included in the FDA Inactive Ingredients Database (liposomal suspension for epidural injections). Included in parenteral medicines (suspension for intrathecal injection) licensed in the UK.
  Triolein is included in the CIR category as safe for use in cosmetics and personal care products. Its use as an indirect food additive has been approved by the FDA.

トリオレイン 上流と下流の製品情報

トリオレイン 生産企業

Global(451)Suppliers

トリオレイン スペクトルデータ(¹HNMR、IR1、IR2、MS)

122-32-7, トリオレイン キーワード