ラクチトール

ラクチトール 価格

ラクチトール 化学特性,用途語,生産方法

• 定義

  本品は、乳糖(*)の部分水添により得られるものであり、次の化学式で表される。
  参照表示名称：乳糖

• 化粧品の成分用途

  保湿.湿潤剤、保水剤、香味剤

• 効能

  高アンモニア血症治療薬, 下剤, 甘味剤

• 化学的特性

  Lactitol occurs as white orthorhombic crystals. It is odorless with a sweet taste that imparts a cooling sensation. It is available in powdered form and in a range of crystal sizes. The directly compressible form is a water-granulated product of microcrystalline aggregates.

• 使用

  Lactitol is listed as an excipient in some prescription drugs, such as Adderall. Lactitol is a sugar alcohol used as a replacement bulk sweetener for low calorie foods. It is also used medically as a laxative.

• 調製方法

  Lactitol is produced by the catalytic hydrogenation of lactose.

• 応用例（製薬）

  Lactitol is used as a noncariogenic replacement for sucrose. It is also used as a diluent in solid dosage forms.(1) A direct-compression form is available,(2,3) as is a direct-compression blend of lactose and lactitol. Lactitol is also used therapeutically in the treatment of hepatic encephalopathy and as a laxative.

• 安全性

  Lactitol is regarded as a nontoxic and nonirritant substance. It is not fermented significantly in the mouth, and is not cariogenic.It is not absorbed in the small intestine, but is broken down by microflora in the large intestine, and is metabolized independently of insulin. In large doses it has a laxative effect; therapeutically, 10–20 g daily in a single oral dose is administered for this purpose.
  LD50 (mouse, oral): >23 g/kg
  LD50 (rat, oral): 30 g/kg

• 貯蔵

  Lactitol as the monohydrate is nonhygroscopic and is stable under humid conditions. It is stable to heat and does not take part in the Maillard reaction. In acidic solution, lactitol slowly hydrolyzes to sorbitol and galactose. Lactitol is very resistant to microbiological breakdown and fermentation. Store in a well-closed container. When the compound is stored in an unopened container at 25°C and 60% relative humidity, a shelf-life in excess of 3 years is appropriate.

• 規制状況(Regulatory Status)

  GRAS listed. Accepted for use as a food additive in Europe. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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