リドカイン 塩酸塩 一水和物

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H301：飲み込むと有毒

リドカイン 塩酸塩 一水和物 価格

リドカイン 塩酸塩 一水和物 化学特性,用途語,生産方法

• 用途

  ナトリウム透過性抑制作用を 示します。塩酸塩はリドカインよりも効果が 迅速です。

• 用途

  ナトリウム透過性抑制作用を 示します。塩酸塩はリドカインよりも効果が 迅速です。

• 効能

  表面麻酔薬, 抗不整脈薬, ナトリウムチャネル遮断薬

• 商品名

  キシロカイン (アスペンジャパン)

• 化学的特性

  Linocaine hydrochloride is a white or almost white, crystalline powder with slightly bitter and numbing taste. Soluble in water, ethanol and organic solvents, insoluble in ether. The aqueous solution does not decompose under acid and alkali conditions, and it rarely deteriorates after repeated autoclaving.

• 使用

  Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

• 主な応用

  Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.

• 定義

  ChEBI: Linocaine hydrochloride is the monohydrate form of lidocaine hydrochloride. It is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of Procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

• 接触アレルゲン

  Linocaine hydrochloride is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.

• 合成

  A method for preparing Lidocaine hydrochloride is described as follows. The method comprises the following steps: by taking 2,6-xylenol as a raw material, Pd/C as a primary catalyst and 2,6-dimethylcyclohexanone as a promoter, performing liquid phase amination with ammonia water at high temperature, thereby obtaining a midbody 2,6-dimethylaniline; enabling sodium methylate, 2,6-dimethylaniline and N,N-lignocaine methyl acetate as raw materials to react at 90-95 DEGC, distilling while reaction is performed to remove methanol till no methanol can be evaporated out, continuously reacting for 30 minutes, cooling to the room temperature, adding dichloroethane, washing with water, and leaving to stand to layer, thereby obtaining an organic layer, namely, a lidocaine based dichloroethane solution; further adding hydrochloric acid into the lidocaine based dichloroethane solution, adjusting the pH value to be 3.5-4 by using hydrogen chloride, adding activated carbon to reflux for 20-40 minutes, filtering, concentrating the filtrate, cooling, crystallizing, and dying, thereby obtaining Lidocaine hydrochloride.

• Mode of action

  Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.

リドカイン 塩酸塩 一水和物 生産企業

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