QX 314 クロライド

QX 314 クロライド 価格

QX 314 クロライド 化学特性,用途語,生産方法

• 使用

  QX 314 chloride is a membrane-impermeant lidocaine derivative that selectively blocks sodium channels on nociceptive neurons when delivered intracellularly via the TRPV1 channel, but is reportedly ineffective with extracellular application. When supplied in combination with 1 μM capsaicin , a TRPV1 receptor agonist, 5 mM QX-314 blocks 98% of sodium current in voltage-clamped nociceptive DRG neurons. QX 314 chloride elicits a long-lasting decrease in the response to painful mechanical and thermal stimuli without imparting the motor deficits (e.g., numbness, paralysis) associated with many conventional local anesthetics. At concentrations ranging from 10-70 mM, peripheral application of QX 314 chloride dose-dependently produces robust local anesthesia with slow onset in the guinea pig intradermal wheal assay, the mouse tail-flick test, and the mouse sciatic nerve blockade model.

• 生物活性

  Membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na + channels.

• Biochem/physiol Actions

  Lidocaine N-ethyl chloride is an intracellular voltage-gated sodium channel blocker.

QX 314 クロライド 生産企業

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QX 314 クロライド スペクトルデータ(¹HNMR、MS)

5369-03-9, QX 314 クロライド キーワード