ベルゲニン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ベルゲニン 価格

ベルゲニン 化学特性,用途語,生産方法

• 外観

  白色の結晶又は結晶性の粉末(JP法)

• 溶解性

  メタノールに溶けやすい。エタノール(99.5)に溶けにくく、水に極めて溶けにくく、ジエチルエーテルにほとんど溶けない。

• 効能

  抗生物質, 抗炎症薬

• 説明

  The plant resources of bergenin are rich, mainly from Rock cabbage (Bergenia purpurascens) and thick leafy rock cabbage (Astilbe macroflora) from Saxifragaceae and the roots, stems, and leaves of bai liang jin (Ardisia crispa) from Ardisia japonica (Thunb.) Blume. In Chinese medicine Rock cabbage (Bergenia purpurascens) is the common folk medicine, with nourishing, stanching bleeding, relieving a cough, and other effects. Its earliest record is contained in the classified herbal in Qing Dynasty .
  There are ten kinds of Rock cabbage (Bergenia purpurascens) in Asia, mainly growing in East Asia, north of South Asia, and southeastern Central Asia. There are seven species (including three endemic species) in China, mainly distributed in Shaanxi (Qinling), Xinjiang, Sichuan, Yunnan, and Tibet .

• 化学的特性

  White powder

• 物理的性質

  Appearance: white, loose needle-like crystal or crystalline powder with light odor and bitter taste and discolored when encountered with light or heat. Solubility: dissolved in methanol and slightly soluble in water or ethanol. Melting point: 232– 240?°C. Specific optical rotation: ?38° to ?45°.

• 来歴

  In 1958, Hay and Haynes first reported the complete synthesis of bergenin, using 4-methoxy gallate and A-D-bromo-2, 3, 4, 6-tetraacetylglucose as raw materials to synthesize bergenin successfully .
  In 1987, Chen Wendou determined the content of bergenin as 5.8% in the alcohol extract of Astilbe chinensis (Maxim.), Franch. et Savat.(Luoxinfu), and Rock cabbage (Bergenia purpurascens) by using high-performance liquid chromatography. In 1991, Wang Junping determined the content of bergenin in the alcohol extract of Rodgersia podophylla as 19.17% with spectrophotometry.
  By doing thin layer qualitative analysis, Liu Nunian discovered that bergenin could be found in seven kinds of plants including sour moss (Ardisia solanacea), Luosan tree (Ardisia quinquegona Bl.), Cinnabar root (Ardisia crenata Sims), Zijinniu (Ardisia japonica), Lianzuozijinniu (Ardisia primulaefolia), Jiujielong (Ardisia pusilla), and Xinyezijinniu (Ardisia maclurei) from Ardisia. In addition, Zhang Yi determined the content of bergenin in the medicinal plants from Ardisiawith high-performance liquid chromatography, and results showed that there were four species of plants with the content of bergenin of more than 1%, having great resource utilization value. There are 11 species of plants with the content of bergenin less than 1%, such as Xiaoqiaomuzijinniu (Ardisia arborescens), twist fruit, fine umbrella (Ardisia affinis Hemsl.), and so on. They had some useful value as well .
  In recent years, it has been found that both 8, 10-dimethylca bergenin and 11-0-gallate betaine had weak inhibitory effects on the tumor in mice, and their effects were stronger than that of bergenin. The effect of acetylated bergenin was stronger than that of bergenin on liver injury induced by chloroform in mice. The new bergenin derivatives from the Ardisia gigantifolia stapf had a certain degree of free radical-scavenging effect and anti-HIV viral activity .

• 使用

  A herbal remedy with antioxidant, antimicrobial and antiinflammatory properties.

• 定義

  ChEBI: A natural product found in Cenostigma gardnerianum.

• 一般的な説明

  This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

• 臨床応用

  Bergenin was recorded in People’s Republic of China Pharmacopoeia as an antitussive expectorant, used for the treatment of chronic bronchitis, emphysema, bronchial asthma, and other respiratory diseases. Used alone, or in compound preparation, such as compound bergenin tablets, Qingjin syrup, Compound Hu ear tablets, Qingfei antitussive syrup, liver poison net particles, Kechuanping oral solution, and silicone lung oral solution, it is mainly used for the treatment of chronic bronchitis. Its efficacy was proven to be relatively stable and improved in the compound preparations after a wide range of clinical validation.

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