ジプロピルアミン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H225：引火性の高い液体および蒸気

  H302：飲み込むと有害

  H314：重篤な皮膚の薬傷?眼の損傷

  H335：呼吸器への刺激のおそれ

• 注意書き

  P210：熱/火花/裸火/高温のもののような着火源から遠ざ けること。－禁煙。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P301+P312：飲み込んだ場合：気分が悪い時は医師に連絡する こと。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ジプロピルアミン 価格

ジプロピルアミン 化学特性,用途語,生産方法

• 外観

  無色～黄色, 澄明の液体

• 溶解性

  水に可溶, アルコールに易溶。エタノール及びエーテルに溶けやすく、水に溶ける。

• 用途

  有機合成原料(医薬、染料、ゴム、農薬、界面活性剤)。

• 用途

  ゴム薬品、農薬原料、医薬品原料

• 用途

  農薬合成原料、有機化学品合成原料、腐食防止剤

• 使用上の注意

  不活性ガス封入

• 化学的特性

  Dipropylamine, like the other short chain aliphatic amines, is a very strong base, its reactivity being governed by the unshared electron pair on the nitrogen atom. It forms a hydrate with water. The amine also can react with inorganic or organic nitrites under acidic conditions and possibly by reaction with nitrogen oxides from the air to form the highly mutagenic and carcinogenic N-nitrosodipropylamine (ATSDR 1979; Olah et al; Scanlan 1983).

• 調製方法

  Dipropylamine is manufactured by reaction of propanol and ammonia over a dehydration catalyst at high temperature and pressure (HSDB 1989). Alternatively, propanol and ammonia can be combined with hydrogen over a dehydrogenation catalyst. In each instance, the resulting mixture of primary, secondary, and tertiary amines can be separated by continuous distillation and extraction (Schweizer et al 1978). Dipropylamine is a natural component of vegetables, fish, fruits, and other foods (Mohri 1987) and of tobacco products (WHO 1987). It also is found in human urine (Audunsson 1988), waste water lagoons (Guzewich et al 1983) and in workplace air (Simon and Lemacon 1987).
  The toxic compound, N-nitrosodipropylamine, can be produced inadvertently by nitrosation of n-dipropylamine during various manufacturing processes that use the diamine (ATSDR 1989). The nitrosamine, therefore, occurs as an impurity in some dinitroaniline pesticides and rubber products. N-nitrosodipropylamine also is found in various foodstuffs including cheese, cured meats, cooked fish and alcoholic beverages, apparently by reaction of n-dipropylamine with the preservative sodium nitrite (ATSDR 1979; Gross and Newberne 1977; Scanlan 1983).

• 一般的な説明

  A clear colorless liquid with an ammonia-like odor. Flash point 30°F. Less dense than water. Vapors heavier than air. Toxic oxides of nitrogen produced during combustion.

• 空気と水の反応

  Highly flammable. Soluble in water.

• 反応プロフィール

  Dipropylamine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

• 健康ハザード

  Inhalation of dipropylamine vapors can result in severe coughing and chest pain due to irritation of airways. Transient symptoms of exposure may include headache, nausea, faintness, and anxiety. Prolonged breathing of vapors may result in lung edema. Dipropylamine also can cause severe irritation and edema of the cornea. A review of the toxicity of dipropylamine has been prepared (Anon 1987).

• 火災危険

  Special Hazards of Combustion Products: Toxic oxides of nitrogen may form in fires.

• 工業用途

  Dipropylamine is used in the rubber industry and as a chemical intermediate in the manufacture of the herbicides S-ethyl-di-n-propylthiocarbamate and S-propyl di-n-propylthiocarbamate (HSDB 1989). Dipropylamine also is employed in the purification of perfluoro compounds to convert the incompletely fluorinated impurities to solids which are then removed by filtration. In 1984, U.S. production was 41 million pounds.

• 安全性プロファイル

  Poison by ingestion. Moderately toxic by shin contact and inhalation. A skin irritant. A very dangerous fire hazard, when exposed to heat or flame. Can react with oxidizers. Explosion hazard is unknown. Keep away from heat and open flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx,. See also AMINES

• 代謝

  There is little information available on the metabolism and disposition of dipropylamine in biological systems. The available evidence suggests that dipropylamine is not a substrate for monoamine oxidase, but rather is inhibitory. Valiev (1974) administered dipropylamine intraperitoneally to rats and reported it to be moderately inhibitory to liver monoamine oxidase. Previous work by this author demonstrated that lethal doses of dipropylamine and other secondary and tertiary amines significantly inhibited rat liver monoamine oxidase activity (Valiev 1968).
  The carcinogenic N-nitrosodipropylamine has been detected in the stomach when dipropylamine (present in fish, vegetables and fruit juices) comes in contact with nitrite, which is often used as a food additive in meats and smoked fish (HSDB 1989). Further metabolism of the carcinogen N-nitrosodipropylamine product formed upon nitrosation of dipropylamine is required to form a highly electrophilic carbonium ion capable of alkylating DNA, etc. (Archer 1981).

ジプロピルアミン 上流と下流の製品情報

ジプロピルアミン 生産企業

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ジプロピルアミン スペクトルデータ(¹HNMR、¹³CNMR、IR1、MS、Raman)

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