キトサン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H315：皮膚刺激

  H319：強い眼刺激

  H335：呼吸器への刺激のおそれ

  H400：水生生物に強い毒性

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P271：屋外または換気の良い場所でのみ使用すること。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

キトサン 価格

MSDS Information

• Chitosan

キトサン 化学特性,用途語,生産方法

• 外観

  うすい黄赤色～黄色～緑色粉末～結晶

• 外観

  白色～うすい黄色～うすい黄赤色粉末～結晶

• 外観

  白色～うすい黄色～暗い緑色粉末～結晶

• 外観

  白色～ほとんど白色粉末～結晶

• 定義

  本品は、キチン(*)を脱アセチル化したものである。参照表示名称：キチン

• 溶解性

  うすい酢酸に溶ける。水に不溶。

• 解説

  キトサン,グルコースの誘導体であるNアセチルDグルコサミンの重合体で，化学構造がセルロースに似た多糖類をキチンといい，その脱アセチル化物をキトサンという。カニ，エビなどの甲殻類や昆虫の外皮，菌類の細胞壁の主要な構成成分で.

• 用途

  各種凝集剤

• 用途

  写真乳剤,合成繊維や織物の染色,広範囲の重金属吸着剤, 各種酸性物質(核酸,エンドトキシンなど)の除去剤、カチオン系活性汚泥凝集剤、植物の生長促進剤。

• 性質

  キトサン,白色の無定形粉末．酸性水溶液に可溶．酸性でヨウ素を作用させると紫色に呈色する．

• 化粧品の成分用途

  ヘアスタイリング剤、皮膜形成剤

• 化学的特性

  Chitosan occurs as odorless, white or creamy-white powder or flakes. Fiber formation is quite common during precipitation and the chitosan may look ‘cottonlike’.

• 天然物の起源

  Chitosan comes from the shell of marine crustaceans.

• 使用

  Forms gels with multivalent anions. Gives clear solutions that dry to strong, clear films.Flocculant, protein precipitation, encapsulating agent and aqueous thickener.
  Chitosan is a natural polycationic linear polysaccharide derived from chitin. The low solubility of chitosan in neutral and alkaline solution limits its application.
  Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications
  

• 調製方法

  Chitosan is manufactured commercially by chemically treating the shells of crustaceans such as shrimps and crabs. The basic manufacturing process involves the removal of proteins by treatment with alkali and of minerals such as calcium carbonate and calcium phosphate by treatment with acid. Before these treatments, the shells are ground to make them more accessible. The shells are initially deproteinized by treatment with an aqueous sodium hydroxide 3–5% solution. The resulting product is neutralized and calcium is removed by treatment with an aqueous hydrochloric acid 3–5% solution at room temperature to precipitate chitin. The chitin is dried so that it can be stored as a stable intermediate for deacetylation to chitosan at a later stage. NDeacetylation of chitin is achieved by treatment with an aqueous sodium hydroxide 40–45% solution at elevated temperature (1108℃), and the precipitate is washed with water. The crude sample is dissolved in acetic acid 2% and the insoluble material is removed. The resulting clear supernatant solution is neutralized with aqueous sodium hydroxide solution to give a purified white precipitate of chitosan. The product can then be further purified and ground to a fine uniform powder or granules. The animals from which chitosan is derived must fulfil the requirements for the health of animals suitable for human consumption to the satisfaction of the competent authority. The method of production must consider inactivation or removal of any contamination by viruses or other infectious agents.

• 利点

  Chitosan is a fibrous substance that might reduce how much fat and cholesterol the body absorbs from foods. It also helps blood clot when applied to wounds.

• 一般的な説明

  Chitosan is a linear amino polysaccharide composed of approximately 20% β1,4-linked N-acetyl-D-glucosamine (GlcNAc) and approximately 80% β1,4-linked D-glucosamine (GlcN) that is prepared by the partial deacetylation of chitin in hot alkali.

• 化学性质

  キチンの側鎖のアセチル基を加水分解したもの

• 応用例（製薬）

  Chitosan is used in cosmetics and is under investigation for use in a number of pharmaceutical formulations. The suitability and performance of chitosan as a component of pharmaceutical formulations for drug delivery applications has been investigated in numerous studies. These include controlled drug delivery applications, use as a component of mucoadhesive dosage forms, rapid release dosage forms, improved peptide delivery, colonic drug delivery systems, and use for gene delivery. Chitosan has been processed into several pharmaceutical forms including gels, films, beads, microspheres, tablets, and coatings for liposomes. Furthermore, chitosan may be processed into drug delivery systems using several techniques including spray-drying, coacervation, direct compression, and conventional granulation processes.

• 安全性

  Chitosan is being investigated widely for use as an excipient in oral and other pharmaceutical formulations. It is also used in cosmetics. Chitosan is generally regarded as a nontoxic and nonirritant material. It is biocompatible with both healthy and infected skin. Chitosan has been shown to be biodegradable.
  LD₅₀ (mouse, oral): >16 g/kg

• 貯蔵

  Chitosan powder is a stable material at room temperature, although it is hygroscopic after drying. Chitosan should be stored in a tightly closed container in a cool, dry place. The PhEur 6.5 specifies that chitosan should be stored at a temperature of 2–88℃.

• 合成方法

  濃アルカリでキチンを処理する

• 不和合性

  Chitosan is incompatible with strong oxidizing agents.

• 規制状況(Regulatory Status)

  Chitosan is registered as a food supplement in some countries.

キトサン 上流と下流の製品情報

キトサン 生産企業

Global(859)Suppliers

キトサン スペクトルデータ(IR)

9012-76-4, キトサン キーワード