ホルマリン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Danger

• 危険有害性情報

  H314：重篤な皮膚の薬傷?眼の損傷

  H317：アレルギー性皮膚反応を起こすおそれ

  H330：吸入すると生命に危険

  H335：呼吸器への刺激のおそれ

  H341：遺伝性疾患のおそれの疑い

  H350：発がんのおそれ

  H370：臓器の障害

• 注意書き

  P202：全ての安全注意を読み理解するまで取り扱わないこ と。

  P260：粉じん/煙/ガス/ミスト/蒸気/スプレーを吸入しないこ と。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P303+P361+P353：皮膚（または髪）に付着した場合：直ちに汚染された衣 類をすべて脱ぐこと/取り除くこと。皮膚を流水/シャワー で洗うこと。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

ホルマリン 価格

MSDS Information

• Formaldehyde

ホルマリン 化学特性,用途語,生産方法

• 外観

  無色澄明の液体

• 定義

  本品は、次の化学式で表される有機化合物である。

• 溶解性

  水、エタノールに混和、ジエチルエーテルに不溶。水、エタノール及びアセトンに極めて溶けやすい。

• 解説

  ホルムアルデヒド,メタナール(methanal)ともいう．有機物質の不完全燃焼ガス中や微量だが空気中にも存在する．実験室的には，メタノール蒸気と酸素を白金網上に通すと得られる．工業的には，メタノールの空気酸化法によって製造される．刺激性の無色の気体．融点－117 ℃，沸点－19.2 ℃．爆発範囲7～73体積％．水，メタノールなどの極性溶剤に易溶，無極性溶剤に難溶．非常に重合しやすいので，水溶液(ホルマリン)または重合状態(パラホルムアルデヒド)で利用される．おもな用途はフェノール樹脂，尿素樹脂，メラミン樹脂などの合成樹脂，およびイソプレン，ペンタエリトリトール，ヘキサメチレンテトラミンなどの製造原料，消毒用などに使われる．有毒．

• 用途

  ポリアセタール樹脂?ユリア樹脂及びメラミン樹脂接着剤?フェノール樹脂?合成ゴム?メラミン樹脂(接着剤を除く)?ユリア樹脂(接着剤を除く)原料、溶剤、医薬?繊維処理剤?紙力増強剤?土木建築材料原料、キレート剤、農薬合成原料、石炭酸系?尿素系?メラミン系合成樹脂、農薬(失効農薬)、消毒剤

• 用途

  タンパクを凝固させる作用があるため、消毒薬として医療器具(濃度1～5%)に用いられる。また、家具(濃度1～2%)や糊などの防腐剤、各種プレパラート作成の固定剤(濃度10～20%)としても用途が広い。2～3%に希釈したホルマリン溶液は、動物標本の作成にも用いられる。アンモニア性硝酸銀溶液にホルマリンを加えて温めると銀イオンを還元して銀を遊離する。これは「銀鏡反応」と呼ばれ、銀染色などに応用されている。その他有機合成原料、分析用等に極めて汎用される。

• 用途

  病理組織固定剤。

• 用途

  ホルマリンとは、ホルムアルデヒドの水溶液で、無色透明?刺激臭のある液体です。プラスチックスや樹脂、合成ゴム、塗料等の原料として使用されます。（別名：メチレンオキサイド?メタナール?メチルアルデヒド）
  ホルマリンは、ポリアセタール樹脂（自動車、家電製品）、ユリア、メラミン樹脂接着剤（住宅）、フェノール樹脂（住宅、自動車、家電）、ペンタエリスリトール（塗料）、MDI（ウレタン原料）、パラホルムアルデヒド、合成ゴム、その他の原料として使用されます。

• 用途

  病理組織の固定剤。

• 化粧品の成分用途

  人工爪剤、爪コンディショニング剤

• 効能

  殺菌消毒薬

• 健康影響

  ホルムアルデヒドは人間の健康に対して潜在的なリスクを持ちます短期間の高濃度曝露は目や鼻喉の刺激頭痛皮膚反応を引き起こすことがあります長期間にわたる低濃度曝露はより深刻な健康問題を引き起こす可能性があります世界保健機関WHOの国際がん研究機関IARCはホルムアルデヒドをヒトに対する発がん性があると分類しています特に長期間にわたる曝露は鼻咽腔がんのリスクを高めるとされています

• 特長

  マイルドホルム10Nにメタノール10v/v%を添加しているため固定浸透性が優れている。

• 商品名

  ホルマリン (健栄製薬); ホルマリン (大成薬品工業); ホルマリン (大成薬品工業); ホルマリン (小堺製薬); ホルマリン (小堺製薬); ホルマリン (小堺製薬); ホルマリン (小堺製薬); ホルマリン (山善製薬); ホルマリン (恵美須薬品化工); ホルマリン (東海製薬)

• 説明

  Formaldehyde is a colorless, flammable gas with a distinctive pungent odor. It is the simplest aldehyde, which is a class of organic compounds with the carbonyl group bonded to at least one hydrogen atom. Formaldehyde was described by August Wilhelm von Hoff mann (1818–1892) in 1867 after the Russian Aleksandr Butlerov (1828–1886) had inadvertently synthesized it in 1857. Formaldehyde readily dissolves in water to produce a solution called formalin, which is commonly marketed as a 37% solution.

• 化学的特性

  Formaldehyde is an important chemical widely used by industry to manufacture building materials and numerous household products. It is also a by-product of combustion and certain other natural processes. It is present in substantial concentrations both indoors and outdoors. Formaldehyde is well known as a preservative in medical laboratories, as an embalming fl uid, and as a sterilizer. Its primary use is in the production of resins and as a chemical intermediate. Urea formaldehyde (uf) and phenol formaldehyde (pf) resins are used in foam insulations, as adhesives in the production of particle board and plywood, and in the treating of textiles. Sources of formaldehyde in the home include building materials, smoking, household products, and the use of unvented, fuel-burning appliances, like gas stoves or kerosene space heaters. Formaldehyde, by itself or in combination with other chemicals, serves a number of purposes in manufactured products. It has been reported that the use and production of formaldehyde in 1998 was about 11.3 billion pounds and the international production crossed over 46 billion pounds in 2004.

• 物理的性質

  Formaldehyde is a clear, colorless liquid with a pungent, suffocating odor. Burning taste. Experimentally determined odor threshold concentrations of 1.0 ppmv and 0.50 ppmv were reported by Leonardos et al. (1969) and Nagata and Takeuchi (1990), respectively. Also,formalin is an aqueous solution that is 37% formaldehyde by weight; inhibited solutions (added to prevent polymeri zation) usually contain 6 12% methyl alcohol. Formaldehyde is used in the manufacture of plastics and resins by reaction with phenols,urea, and melamine. It is used as a preservative,a disinfectant, and as a chemical intermediate.

• 来歴

  Formaldehyde is a by-product of combustion of organic compounds, metabolism, and other natural processes. Formaldehyde results from wood combustion and elevated atmospheric concentrations can result from forest fires, as well as from urban pollution sources such as transportation. Formaldehyde has been identified as a significant indoor air pollutant. Building materials such as particleboard, plywood, and paneling are major sources of formaldehyde because they incorporate formaldehyde resins as bonding adhesives. Other sources of formaldehyde in the home are carpets, upholstery, drapes, tobacco smoke, and indoor combustion products. Formaldehyde may be emitted from building materials for several years after installation. In the two decades of the 1960s and 1970s, a half million homes in the United States used urea formaldehyde foam insulation, but health complaints led to its elimination as an insulator in the early 1980s. People react differently to formaldehyde exposure, but it is estimated that between 10% and 20% of the population will experience some reaction at concentrations as low as 0.2 parts per million. Formaldehyde irritates the eyes, nose, and throats, producing coughing, sneezing, runny nose, and burning eyes. More severe reactions result in insomnia, headaches, rashes, and breathing difficulties. Some states have established indoor air quality standards ranging from 0.05 to 0.5 ppm.

• 使用

  Formaldehyde is used in the manufactureof phenolic resins, cellulose esters, artificialsilk, dyes, explosives, and organic chemicals.Other uses are as a germicide, fungicide, anddisinfectant; in tanning, adhesives, waterproofingfabrics, and for tonic and chromeprinting in photography; and for treating skindiseases in animals. In vitro neutralizationof scorpion venom toxicity by formaldehydehas been reported (Venkateswarlu et al.1988).
  Formaldehyde constitutes about 50% ofall aldehydes present in the air. It is oneof the toxic effluent gases emitted fromburning wood and synthetic polymeric substancessuch as polyethylene, nylon 6, andpolyurethane foams. Firefighters have a greaterrisk to its exposure. Incapacitation fromthe toxic effluent gases is reported to occurmore rapidly from the combustion of syntheticpolymers than from that of naturalcellulose materials.
  Formaldehyde is directly emitted into theair from vehicles. It is released in traceamounts from pressed wood products suchas particleboard and plywood paneling, fromold “sick” buildings, and from cotton andcotton–polyester fabrics with selected crosslinkfinishes. Formation of formaldehyde hasbeen observed in some frozen gadoid fishdue to enzymic decomposition of the additivetrimethylamine oxide (Rehbein 1985).Its concentration can build up during frozenstorage of fish (Leblanc and Leblanc 1988;Reece 1985). It occurs in the upper atmosphere,cloud, and fog; it also forms inphotochemical smog processes.

• 定義

  Formalin: a colourless solution of methanal (formaldehyde) in waterwith methanol as a stabilizer; r.d.1.075–1.085. When kept at temperaturesbelow 25°C a white polymer ofmethanal separates out. It is used asa disinfectant and preservative forbiological specimens.

• 調製方法

  The industrial preparation of formaldehyde has occurred since the late 1800s and involvesthe catalytic oxidation of methanol: 2CH₃OH(g) + O₂(g) → 2CH₂O(g).the oxidationtakes place at temperatures between 400°C and 700°C in the presence of metal catalysts. Metalsinclude silver, copper, molybdenum, platinum, and alloys of these metals. Formaldehyde iscommonly used as an aqueous solution called formalin. Commercial formalin solutions varybetween 37% and 50% formaldehyde. When formalin is prepared, it must be heated anda methanol must be added to prevent polymerization; the final formalin solution containsbetween 5% and 15% alcohol.

• 製造方法

  Formalin is adjusted to pH 8 and urea is added to give a urea to formaldehyde ratio of about 1 :2.5 molar. The resulting solution is boiled under reflux for 1 hour. Butanol (1.5-2.0 mole per mole of urea) is then added together with a little xylene. The latter forms, with butanol and water, a ternary azeotrope which on distillation yields a condensate separating into an upper organic layer and a lower aqueous layer. By discarding the lower layer and returning the upper layer to the reactor, water is progressively removed from the system. After a substantial proportion of the water has been removed, an acid catalyst (e.g. phosphoric acid or phthalic anhydride) is added and heating is continued. When the required degree of reaction is attained, the solution is neutralized and concentrated to the desired solids content.

• 安全性

  ホルムアルデヒドの健康への潜在的なリスクを鑑み多くの国ではこの化学物質に関する規制を設けています例えば室内空気質の基準値を定めることにより人々が安全な環境で生活し働くことができるようにしていますまた製品に含まれるホルムアルデヒドの量を制限することで消費者が曝露を避けられるように配慮されています

• 毒性

  ホルムアルデヒドは生活環境中では建材、塗料、接着剤などの原料として使われているが、毒性が強く、視覚障害、皮膚や消化器の炎症、鼻や咽頭(いんとう)の粘膜の刺激などの症状を引き起こす。木材、石炭、砂糖など多くの有機化合物が不完全燃焼する際の煙にはホルムアルデヒドが含まれているので、目や鼻の粘膜が刺激され、痛みや炎症をおこす。また、建材や建築用接着剤に含まれているホルムアルデヒドはシックハウス症候群

• 工業的製法

  メタノール（メチルアルコール）の接触酸化によって生成する。この反応は、メタノールの蒸気と酸素を赤熱した白金、銅、または銀網上に通すとおこり、反応熱が触媒を熱するから触媒を加熱し続ける必要がない。工業的にも、メタノールと空気の混合ガスを加熱して銀またはモリブデン鉄混合酸化物触媒上に通して反応させると得られる。この反応はメタノール‐空気混合ガスの爆発範囲（メタノール7～37％）を避けて行う必要があり、そのためにメタノールを約50％含む混合ガスを用いるメタノール過剰法と、メタノールを約5％にした空気過剰法の2通りの製法がある。現在では、空気の使用量が少なく、動力の点で有利な前者がおもな工業的製法になっている。

  

• 一般的な説明

  Formaldehyde solution commercially formaldehyde solution is an aqueous solution containing 37% formaldehyde and 8-10% methanol. Formaldehyde solution can be activated by adding the catalytic amount of lanthanide triflate. This activated formaldehyde solution was employed for the smooth hydroxymethylation reaction of silyl enol ethers. Formaldehyde solution reacts with silyl enol ethers to afford the corresponding hydroxymethylated adducts in high yields.

• 空気と水の反応

  The solution gives up formaldehyde vapors readily. These vapors are flammable over a wide vapor-air concentration range. Water soluble.

• 反応プロフィール

  FORMALDEHYDE, SOLUTION, reacts violently with strong oxidizing agents (hydrogen peroxide, performic acid, perchloric acid in the presence of aniline, potassium permanganate, nitromethane). Reacts with bases (sodium hydroxide, potassium hydroxide, ammonia), and with nitrogen dioxide (explosive reaction around 180°C). Reacts with hydrochloric acid to form highly toxic bis(chloromethyl) ether. Polymerization reaction with phenol may develop sudden destructive pressure [Bretherick, 5th ed., 1995, p.168].

• 危険性

  Moderate fire risk. Explosive limits in air 7– 73%. Toxic by inhalation, strong irritant, a carcinogen. (Solution) Avoid breathing vapor and avoid skin contact. Confirmed carcinogen.

• 健康ハザード

  Formaldehyde is moderately toxic by skin contact and inhalation. Exposure to formaldehyde gas can cause irritation of the eyes and respiratory tract, coughing, dry throat, tightening of the chest, headache, a sensation of pressure in the head, and palpitations of the heart. Exposure to 0.1 to 5 ppm causes irritation of the eyes, nose, and throat; above 10 ppm severe lacrimation occurs, burning in the nose and throat is experienced, and breathing becomes difficult. Acute exposure to concentrations above 25 ppm can cause serious injury, including fatal pulmonary edema. Formaldehyde has low acute toxicity via the oral route. Ingestion can cause irritation of the mouth, throat, and stomach, nausea, vomiting, convulsions, and coma. An oral dose of 30 to 100 mL of 37% formalin can be fatal in humans. Formalin solutions can cause severe eye burns and loss of vision. Eye contact may lead to delayed effects that are not appreciably eased by eye washing.Formaldehyde is regulated by OSHA as a carcinogen (Standard 1910.1048) and is listed in IARC Group 2A ("probable human carcinogen"). This substance is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Prolonged or repeated exposure to formaldehyde can cause dermatitis and sensitization of the skin and respiratory tract. Following skin contact, a symptom free period may occur in sensitized individuals. Subsequent exposures can then lead to itching, redness, and the formation of blisters

• 燃焼性と爆発性

  Formaldehyde gas is extremely flammable; formalin solution is a combustible liquid (NFPA rating = 2 for 37% formaldehyde (15% methanol), NFPA rating = 4 for 37% formaldehyde (methanol free)). Toxic vapors may be given off in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight formaldehyde fires.

• 化学反応性

  Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

• 农业用途

  Microbiocide, Fungicide, Bactericide; Soil sterilent: Registered for use in the U.S. Not approved for use in EU countries. Formaldehyde has found wide industrial usage as a fungicide, germicide and in disinfectants. It is used most often in an aqueous solution stabilized with methanol (formalin). It is also a pesticide intermediate.

• 製品名

  DYNOFORM®; FANNOFORM®; FORMALITH®; FORMOL®; FYDE®; HERCULES 37 M6-8®; HOCH®; IVALON®; KARSAN®; LYSOFORM®; MAGNIFLOC 156C FLOCCULANT®; MORBICID®; STERIFORM®; SUPERLYSOFORM®

• 接触アレルゲン

  Sources and uses of formaldehyde are numerous. Exposed people are mainly health workers, cleaners, painters, met alworkers, but also photographers (color developers) and carbonless copy paper users. Formaldehyde can induce contact urticaria. Formaldehyde may be the cause of sen sitization to formaldehyde releasers: benzylhemiformal, bromonitrodioxane, bromonitropropanediol (), chloroal lylhexaminium chloride or Quaternium-15, diazolidinylu rea, dimethylol urea, dimethyloldimethylhydantoin or DMDM hydantoin, hexamethylenetetramine or methe namine, imidazolidinylurea, monomethyloldimethylhy dantoin or MDM hydantoin, N-methylolchloracetamide, paraformaldehyde and trihydroxyethylhexahydrotriazine or Grotan BK. Formaldehyde is used for the synthesis of many resins. Some of them, such as formaldehyde-urea and melamine formaldehyde resins, can be used in textiles and second arily release free formaldehyde (see Chap. 40). Other resins, such as p-tert-butylphenol formalde hyde resin or tosylamine formaldehyde resin, do not release formaldehyde.

• 職業ばく露

  Formaldehyde has found wide indus trial usage as a fungicide, germicide; and in disinfectants and embalming fluids. It is also used in the manufacture of artificial silk and textiles, latex, phenol, urea, thiourea and melamine resins; dyes, and inks; cellulose esters and other organic molecules; mirrors, and explosives. It is also used in the paper, photographic, and furniture industries. It is an intermediate in drug manufacture and is a pesticide intermediate.

• 概要

  ホルムアルデヒドはその広範な用途によって日常生活の多くの側面に影響を及ぼしていますしかしその健康への潜在的なリスクは規制による管理と個人の意識向上によって軽減されることが期待されます消費者としては製品の選択にあたってホルムアルデヒド含有量を考慮することそして可能な限り曝露を避けるための対策を講じることが重要です国や地域の規制は公衆衛生の保護を目的としていますが日々の生活の中で意識的な選択を行うことによって私たち自身の健康をさらに守ることができます

• 発がん性

  Formaldehyde is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans and supporting data on mechanisms of carcinogenesis. Formaldehyde was first listed in the Second Annual Report on Carcinogens in 1981 as reasonably anticipated to be a human carcinogen based on sufficient evidence from studies in experimental animals. Since that time, additional cancer studies in humans have been published, and the listing status was changed to known to be a human carcinogen in the Twelfth Report on Carcinogens (2011).

• 環境運命予測

  Biological. Biodegradation products reported include formic acid and ethanol, each of which can further degrade to carbon dioxide (Verschueren, 1983).
  Photolytic. Major products reported from the photooxidation of formaldehyde with nitrogen oxides are carbon monoxide, carbon dioxide and hydrogen peroxide (Altshuller, 1983). In synthetic air, photolysis of formaldehyde gave hydrochloric acid and
  Irradiation of gaseous formaldehyde containing an excess of nitrogen dioxide over chlorine yielded ozone, carbon monoxide, nitrogen pentoxide, nitryl chloride, nitric acid and hydrochloric acid. Peroxynitric acid was the major photolysis product when chlo
  Chemical/Physical. Oxidizes in air to formic acid (Hartley and Kidd, 1987). Trioxymethylene may precipitate under cold temperatures (Sax, 1984). Polymerizes easily (Windholz et al., 1983). Anticipated products from the reaction of formaldehyde with ozone orhydroxyl radicals in air are carbon monoxide and carbon dioxide (Cupitt, 1980). Major products reported from the photooxidation of formaldehyde with nitrogen oxides are carbon monoxide, carbon dioxide and hydrogen peroxide (Altshuller, 1983).
  Reacts with hydrochloric acid in moist air forming bis(chloromethyl)ether. This compound may also form from an acidic solution containing chloride ion and formaldehyde (Frankel et al., 1974). In an aqueous solution at 25°C, nearly all the formaldehyde add

• 貯蔵

  work with formaldehyde should be conducted in a fume hood to prevent exposure by inhalation, and splash goggles and impermeable gloves should be worn at all times to prevent eye and skin contact. Formaldehyde should be used only in areas free of ignition sources. Containers of formaldehyde should be stored in secondary containers in areas separate from oxidizers and bases.

• 輸送方法

  UN1198 Formaldehyde solutions, flammable, Hazard Class: 3; Labels: 3-Flammable liquid, 8-Corrosive material. Cylinders must be transported in a secure upright position, in a well-ventilated truck. Protect cylinder and labels from physical damage. The owner of the compressed gas cylinder is the only entity allowed by federal law (49CFR) to transport and refill them. It is a violation of transportation regulations to refill compressed gas cylinders without the express written permission of the owner. UN2209 Formaldehyde solutions, with not<25% formal dehyde, Hazard class: 8; Labels: 8-Corrosive material. UN3077 For solids containing varying amounts of formal dehyde : UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.

• 純化方法

  It commonly contains added MeOH. Add KOH solution (1 mole KOH: 100 moles HCHO) to ~37% by weight aqueous formaldehyde solution (formalin), or evaporate to dryness, to give paraformaldehyde polymer which, after washing with water, is dried in a vacuum desiccator over P2O5 or H2SO4. Formaldehyde is regenerated by heating the paraformaldehyde to 120o under vacuum, or by decomposing it with barium peroxide. The monomer, a colourless flammable gas, is passed through a glass-wool filter cooled to -48o in a CaCl2/ice mixture to remove particles of polymer, then dried by passage over P2O5 and either condensed in a bulb immersed in liquid nitrogen or absorbed in ice-cold conductivity water. The gas or aqueous solutions have pungent suffocating odours, are LACHRYMATORY and suspected carcinogens, handle carefully. Formalin is a disinfectant and a preservative of dead animal and plant tissues. [Beilstein 1 IV 3017.]

• 不和合性

  Pure formaldehyde may polymerize unless properly inhibited (usually with methanol). May form explosive mixture with air. Incompatible with strong acids; amines, strong oxidizers; alkaline materials; nitrogen dioxide; performic acid; phenols, urea. Reaction with hydrochloric acid forms bis-chloromethyl ether, a carcino gen. Formalin is incompatible with strong oxidizers, alkalis, acids, phenols, urea, oxides, isocyanates, caustics, anhydrides.

• 廃棄物の処理

  Return refillable compressed gas cylinders to supplier. Incineration in solution of combus tible solvent. Consult with environmental regulatory agen cies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, trans portation, treatment, and waste disposal.

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