アネトールトリチオン

危険有害性情報のコード(GHS)

• 絵表示(GHS)

  

• 注意喚起語

  Warning

• 危険有害性情報

  H302：飲み込むと有害

  H315：皮膚刺激

  H319：強い眼刺激

  H332：吸入すると有害

  H335：呼吸器への刺激のおそれ

• 注意書き

  P261：粉じん/煙/ガス/ミスト/蒸気/スプレーの吸入を避ける こと。

  P280：保護手袋/保護衣/保護眼鏡/保護面を着用するこ と。

  P305+P351+P338：眼に入った場合：水で数分間注意深く洗うこと。次にコ ンタクトレンズを着用していて容易に外せる場合は外す こと。その後も洗浄を続けること。

アネトールトリチオン 価格

アネトールトリチオン 化学特性,用途語,生産方法

• 外観

  うすい赤黄色～褐色、結晶～結晶性粉末

• 溶解性

  アセトンにやや溶けやすく、エタノール(95)にやや溶けにくく、水に極めて溶けにくい。

• 用途

  コリン作動性を有しており、 唾液分泌作用を示します。

• 効能

  唾液分泌促進薬

• 使用

  Anethole trithione is a choleretic drug that can be effective in the treatment of dry mouth, including drug-induced xerostomia. Research suggests that Anethole trithione may exert its therapeutic effects by acting on the alpha-CGRP nerves in the salivary glands, which in turn promotes salivary secretion^[1-2].

• 製造方法

  Anethole trithione can be obtained by the cyclization of anethole and sulfur. Add aniseed oil and dimethylformamide to the reaction tank, stir, and then add sulfur powder. Heat to 146–150 °C, and maintain the reaction for 1.5 hours. At the end of the reaction, cool to 80 °C, recover dimethylformamide under reduced pressure, then cool the reaction mixture to 66 °C. Add xylene and activated carbon, heat to 108 °C, and hold for half an hour before hot filtration. Cool the filtrate to 0 °C to crystallize, then filter and wash with water to obtain the crude product. After refining with xylene or butyl acetate, the final product of anethole trithione is obtained. The yield is 40%.

• 薬物動態学

  Anethole trithione (ATT) appears to have a broad range of unique functions, from increasing salivary secretion to help treat xerostomia, to demonstrating an ability to inhibit carcinogenesis by increasing the activity of electrophile detoxification enzymes, and even being used as an adjunctive therapy for cholecystitis, gallstone, indigestion, and acute/chronic hepatitis and is marketed in certain countries like France, Germany, and China. Unfortunately, many of the specific mechanisms of action to these activities have yet to be formally elucidated, which means that while studies are ongoing, ATT itself is not necessarily formally indicated for many of these aforementioned functions at this time and is only used in limited regions around the world.

• 安全性プロファイル

  Poison by intramuscular route.Moderately toxic by ingestion and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of SOx.

アネトールトリチオン 上流と下流の製品情報

アネトールトリチオン 生産企業

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アネトールトリチオン スペクトルデータ(¹HNMR)

532-11-6, アネトールトリチオン キーワード