N,N-ジエチルニコチンアミド

化学名:N,N-ジエチルニコチンアミド

CAS番号.59-26-7

英語名:N,N-DIETHYLNICOTINAMIDE

CBNumberCB3677171

MFC10H14N2O

MW178.23

别名

N,N-ジエチルニコチンアミド

コラコン

ニコリン

N,N-ジエチルニコチンアミド物理性質

融点	23 °C (lit.)
沸点	296-300 °C (lit.)
比重(密度)	1.06 g/mL at 25 °C (lit.)
屈折率	n20/D 1.524(lit.)
闪点	>230 °F
貯蔵温度	2-8°C
溶解性	Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
酸解離定数(Pka)	pKa 3.46(H2O,t =20) (Uncertain)
外見	液体
色	無色透明～黄色
Merck	14,6543
BRN	5743
InChI	InChI=1S/C10H14N2O/c1-3-12(4-2)10(13)9-6-5-7-11-8-9/h5-8H,3-4H2,1-2H3
InChIKey	NCYVXEGFNDZQCU-UHFFFAOYSA-N
SMILES	C1=NC=CC=C1C(N(CC)CC)=O
CAS データベース	59-26-7(CAS DataBase Reference)
EPAの化学物質情報	Nikethamide (59-26-7)

安全性情報

危険有害性情報のコード(GHS)

効能
呼吸促進薬
説明
A further Corydalis alkaloid, coramine has been obtained from C. pseudoadunca M. Pop. It forms colourless needles from EtOH and is optically active with a specific rotation of [α]_D - 391 ° (c 0.2, MeOH). Both the hydrochloride, m.p. 216-9°C and the hydrobromide, m.p. 223-6°C have been described.
化学的特性
clear colorless to yellow liquid
使用
analeptic
主な応用
N,N-Diethylnicotinamide (DENA) is one of the central respiratory stimulants and is used in the study of respiratory failure. DENA is also an excellent hydrophilic agent for paclitaxel (PTX) and improves the water solubility of PTX.
一般的な説明
Clear light yellow viscous liquid or crystalline solid. Slightly bitter taste followed by a faint sensation of the warmth.
空気と水の反応
Water soluble.
反応プロフィール
N,N-DIETHYLNICOTINAMIDE is incompatible with sodium carbonate solutions which cause precipitation. .
健康ハザード
ACUTE/CHRONIC HAZARDS: When heated to decomposition N,N-DIETHYLNICOTINAMIDE emits toxic fumes.
火災危険
N,N-DIETHYLNICOTINAMIDE is combustible.
安全性プロファイル
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
参考文献
Yunusov, Akramov, Yunusov, Dokl. Akad. Nauk. USSR, 162,607 (1965)
Yunusov, Akramov, Yunusov, Khim. Prir. Soedin., 2, 340 (1966)
Ibragimova, Yunusov, Yunusov, ibid, 6,438 (1970)
Yunusov, et al., ibid, 7, 380 (1971)