Description
20-
carboxy LTB
4 is a metabolite of LTB
4 in human neutrophils. In human leukocytes, LTB
4 is inactivated by the enzyme LTB
4 20-
hydroxylase. The resulting 20-
hydroxy LTB
4 is further oxidized to 20-
carboxy LTB
4. LTB
4 metabolism in isolated rat hepatocytes also results in production of 20-
carboxy LTB
4 along with other ω-
oxidation products. The biological activity of 20-
carboxy LTB
4 is only about 2.6% compared to that of LTB
4 in causing PMNL degranulation.
Uses
20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways.
Definition
ChEBI: A member of the class of leukotrienes that is leukotriene B4 in which the terminal methyl group has undergone formal oxidation to the corresponding carboxylic acid.
IC 50
Human Endogenous Metabolite; BLT1
References
[1] GRAN HANSSON . Identification and biological activity of novel ω-oxidized metabolites of leukotriene B4 from human leukocytes[J]. FEBS Letters, 1981, 130 1: Pages 107-112. DOI:
10.1016/0014-5793(81)80676-x[2] T. HARPER R M M Garrity. Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite.[J]. The Journal of Biological Chemistry, 1986, 140 1: 5414-5418. DOI:
10.1016/s0021-9258(19)57231-3[3] STEVEN J. FEINMARK. Stimulation of human leukocyte degranulation by leukotriene B4 and its ω-oxidized metabolites[J]. FEBS Letters, 1981, 136 1: Pages 141-144. DOI:
10.1016/0014-5793(81)81233-1
