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20-carboxy LTB₄ is a metabolite of LTB₄ in human neutrophils. In human leukocytes, LTB₄ is inactivated by the enzyme LTB₄ 20-hydroxylase. The resulting 20-hydroxy LTB₄ is further oxidized to 20-carboxy LTB₄. LTB₄ metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB₄ along with other ω-oxidation products. The biological activity of 20-carboxy LTB₄ is only about 2.6% compared to that of LTB₄ in causing PMNL degranulation.

20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways.

ChEBI: A member of the class of leukotrienes that is leukotriene B4 in which the terminal methyl group has undergone formal oxidation to the corresponding carboxylic acid.