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Minoxidil sulphate

Application
Minoxidil sulphate Structure
Minoxidil sulphate
  • CAS No.83701-22-8
  • Chemical Name:Minoxidil sulphate
  • CBNumber:CB9494019
  • Molecular Formula:C9H15N5O4S
  • Formula Weight:289.31
  • MOL File:83701-22-8.mol
Minoxidil sulphate Property
  • Melting point 175-180°C
  • Density 1.75±0.1 g/cm3(Predicted)
  • RTECS UV6260494
  • storage temp. -20°C
  • solubility Acetone (Slightly), DMSO (Slightly)
  • form White solid.
  • pka -4.99±0.18(Predicted)
  • color White to Off-White
  • Stability Light Sensitive - Protect from Light, Store in Freezer
  • InChI InChI=1S/C9H15N5O4S/c10-7-6-8(13-4-2-1-3-5-13)12-9(11)14(7)18-19(15,16)17/h6,10H,1-5H2,(H2,11,12)(H,15,16,17)
  • InChIKey AGMYAAIWWVATKU-UHFFFAOYSA-N
  • SMILES C1(N)N(OS(O)(=O)=O)C(=N)C=C(N2CCCCC2)N=1
  • CAS DataBase Reference 83701-22-8(CAS DataBase Reference)
  • EWG's Food Scores 1
  • FDA UNII 2H6K6Y231J
  • UNSPSC Code 12352107
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335-H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P301+P312-P302+P352-P305+P351+P338-P301+P312+P330-P302+P352-P305+P351+P338
Minoxidil sulphate Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: M7920
  • Product name : Minoxidil sulfate salt
  • Purity: 
  • Packaging: 1MG
  • Price: ₹7263.58
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: M7920
  • Product name : Minoxidil sulfate salt
  • Purity: 
  • Packaging: 5MG
  • Price: ₹19625.73
  • Updated: 2022/06/14
  • Buy: Buy

Minoxidil sulphate Chemical Properties,Usage,Production

  • Application
    Minoxidil sulfate was the drug approved by the FDA for the treatment of androgenetic alopecia (hair loss). Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp. The water solubility characteristics of minoxidil sulfate increases the absorption. 
    Before that, minoxidil sulfate had been used as vasodilator drug prescribed as an oral tablet to treat high blood pressure and it’s can used for refractory hypertension and renal hypertension. Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability.
  • Chemical Properties White Crystalline Solid
  • Uses Minoxidil sulfate (MXS) has been used as a drug agent to study its effects on alopecia in corticotropin-releasing factor over-expressing (CRF-OE) mice. It has also been used as a positive control in an assay for the culturing of rat vibrissa follicles.
  • Uses specifically opens ATP-sensitive K channels, strong vascular smooth muscle relaxer, active minoxidil metabolite
  • Uses A selective ATP-sensitive potassium channel opener. It is the active metabolite of minoxidil and is a potent (IC50=0.14) vascular smooth muscle relaxant
  • Biological Functions Minoxidil sulfate is the active metabolite of Minoxidil and is a potent (IC50=0.14M) vascular smooth muscle relaxant. Minoxidil sulfate is a selective ATP-sensitive potassium channel opener.
  • Biochem/physiol Actions Minoxidil sulfate (MXS) is an endogenous derivative of minoxidil. It possesses greater aqueous solubility and is a potent vasodilator. MXS has the potential to treat androgenic alopecia or male baldness.
  • in vitro Minoxidil sulfate (1-100 μM; 2 hours) significantly reduces the permeability of bloode-brain tumor barrier (BTB) in a monolayer of RBMEC in a time-dependent manner, additionally,the effects of MS on transendothelial electrical resistance (TEER) is Transendothelial electrical resistance (TEER) at 2 h with high concentration.Minoxidil sulfate (0-100 μM; 0-4 hours) increases the RhoA activation in brain tumor tissue by 1 h and the highest level appears at 2 h, it also significantly induces transient PKB phosphorylation at Ser-473, without affecting total PKB levels. Addiotionally, LY294002 partly prevents the phosphorylation of PKB induced by MS.
Minoxidil sulphate Preparation Products And Raw materials
Raw materials
Preparation Products
Minoxidil sulphate Suppliers
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