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GUANABENZ ACETATE

GUANABENZ ACETATE Structure
GUANABENZ ACETATE
  • CAS No.23256-50-0
  • Chemical Name:GUANABENZ ACETATE
  • CBNumber:CB9491023
  • Molecular Formula:C10H12Cl2N4O2
  • Formula Weight:291.13
  • MOL File:23256-50-0.mol
GUANABENZ ACETATE Property
  • Melting point 227-229℃ (decomposition)
  • storage temp. Keep in dark place,Inert atmosphere,Room temperature
  • solubility H2O: 11 mg/mL
  • form solid
  • color white
  • Water Solubility water: 5mg/mL
  • Merck 14,4558
  • Stability Hygroscopic
  • FDA UNII 443O19GK1A
  • NCI Drug Dictionary guanabenz acetate
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301
  • Precautionary statements P264-P270-P301+P310-P405-P501
GUANABENZ ACETATE Price More Price(6)
  • Brand: Sigma-Aldrich(India)
  • Product number: G110
  • Product name : Guanabenz acetate salt
  • Purity: powder
  • Packaging: 25MG
  • Price: ₹6224.38
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: G110
  • Product name : Guanabenz acetate salt
  • Purity: powder
  • Packaging: 100MG
  • Price: ₹14527.15
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: G110
  • Product name : Guanabenz acetate salt
  • Purity: powder
  • Packaging: 500MG
  • Price: ₹45161.9
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 370625
  • Product name : Guanabenz Acetate - CAS 23256-50-0 - Calbiochem
  • Purity: A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.
  • Packaging: 250MG
  • Price: ₹17660.01
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: G0456
  • Product name : Guanabenz Acetate
  • Purity: 
  • Packaging: 200MG
  • Price: ₹6300
  • Updated: 2022/05/26
  • Buy: Buy

GUANABENZ ACETATE Chemical Properties,Usage,Production

  • Uses antihypertensive
  • Uses α2-adrenergic agonist and IGRS selective ligand
  • Definition ChEBI: Guanabenz acetate is a dichlorobenzene. It has a role as a geroprotector.
  • brand name Wytensin (Wyeth).
  • General Description Guanabenz acetate, [(2,6-dichlorobenzylidene)amino]guanidine monoacetate (Wytensin), is acentral 2-adrenergic agonist that reduces the release of norepinephrinefrom the neuron when stimulated. The effect ofthe drug results in decreased sympathetic tone in the heart,kidneys, and peripheral blood vessels. The drug does not produceorthostatic hypotension.
  • Biological Activity α 2 -adrenergic agonist and IGRS (imidazoline I 2 binding site) selective ligand.
  • Biochem/physiol Actions Centrally acting α2 adrenoceptor agonist; I2 imidazoline binding site ligand; antihypertensive.
  • Pharmacokinetics The oral bioavailability of guanabenz is 70 to 80%. Following an oral dose, the hypotensive effect of guanabenz begins within 1 hour, peaks within 2 to 7 hours, and is diminished within 6 to 8 hours. It has an elimination half-life averaging 4 to 14 hours. The blood pressure response can persist for at least 12 hours. Following IV dosing, guanabenz is distributed into the CNS, with brain concentrations 3 to 70 times higher than concurrent plasma concentrations. Guanabenz is approximately 90% bound to plasma proteins. In patients with hepatic or renal impairment, its elimination half-life may be prolonged.
    Guanabenz is metabolized principally by hydroxylation to its inactive metabolite, 4-hydroxyguanabenz, which is eliminated in the urine as its glucuronide (major) and sulfate conjugates. Guanabenz and its inactive metabolites are excreted principally in urine, with approximately 70 to 80% of its oral dose excreted in urine within 24 hours and approximately 10–30% in feces via enterohepatic cycling. Approximately 40% of an oral dose of guanabenz is excreted in urine as 4-hydroxyguanabenz and its glucuronide, and less than 5% is excreted unchanged. The remainder is excreted as unidentified metabolites and their conjugates.
  • Clinical Use Overall, the therapeutic applications for guanabenz are similar to those of clonidine and other α2-adrenergic agonists. One advantage for guanabenz is its once-a-day dosing schedule. Guanabenz has been used in diabetic patients with hypertension without adverse effect on the control of or therapy for diabetes, and it has been effective in hypertensive patients with chronic obstructive pulmonary disease, including asthma, chronic bronchitis, or emphysema. Guanabenz has been used alone or in combination with naltrexone in the management of opiate withdrawal in patients physically dependent on opiates and undergoing detoxification. Guanabenz also has been used as an analgesic in a limited number of patients with chronic pain
  • Side effects Overall, the frequency of adverse effects produced by guanabenz is similar to that produced by clonidine and the other α2-adrenergic agonists, but the incidence is lower. As with the other centrally active sympatholytics (e.g., clonidine), abrupt withdrawal of guanabenz may result in rebound hypertension, but the withdrawal syndrome symptoms appear to be less severe.
  • storage Store at RT
GUANABENZ ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
GUANABENZ ACETATE Suppliers
Global(160)Suppliers
  • Supplier：
    career henan chemical co
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  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    AFINE CHEMICALS LIMITED
  • Tel：+86-0571-85134551
  • Email：sales@afinechem.com
  • Country：China
  • ProdList：15395
  • Advantage：58
GUANABENZ ACETATE Spectrum
23256-50-0, GUANABENZ ACETATERelated Search:
  • WYTENSIN
  • Inhibitors
  • 抑制剂
  • 配体家族
  • 小分子抑制剂，天然产物
  • 胍
  • C8H8Cl2N4C2H4O2
  • C8H8Cl2N4CH3CO2H
  • 4-咪唑乙酸盐酸盐,10 MM DMSO 溶液
  • (E)-2-(2,6-二氯苄亚基)肼甲脒 乙酸酯
  • WY8678 ACETATE|||BR-750|||4-咪唑乙酸盐酸盐|||WYTENSIN
  • 2-(2,6-二氯苄亚基)肼甲脒 乙酸酯
  • 2-(2,6-二氯亚苄基)肼基-1-甲脒乙酸盐
  • 醋酸胍
  • 胍那苄乙酸盐
  • 醋酸胍那苄 USP标准品
  • 醋酸胍苄酯
  • GUANABENZ 乙酸酯
  • 乙酸胍那苄, ≥98%
  • 醋酸氯苄氨胍
  • 肼甲脒, 2-[(2,6-二氯苯基)亚甲基]-, 乙酸酯
  • 胍那苄单乙酸盐
  • 胍那苄醋酸盐
  • 氯苄氨胍醋酸盐
  • 醋酸胍那苄
  • 4-咪唑乙酸盐酸盐
  • 乙酸瓜那苄
  • 乙酸胍那苄
  • 23256-50-0
  • Guanabenz Acetate, 10 mM in DMSO
  • 2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide acetate
  • 2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide acetate
  • Guanabenz Acetate (1301404)
  • Guanabenz Acetate (BR-750
  • GUANABENZ ACETATE USP/EP/BP
  • GuanabenzAcetate&gt
  • (E)-2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide acetate
  • Guanabenz Acetate - CAS 23256-50-0 - Calbiochem
  • Guanabenz Acetate, ≥98%
  • Hydrazinecarboximidamide, 2-[(2,6-dichlorophenyl)methylene]-, acetate (1:1)
  • Wytens
  • Wy 8678 acetate
  • Tenelid
  • HydrazinecarboxiMidaMide, 2-[(2,6-dichlorophenyl)Methylene]-, acetate
  • Guanabenz Acetate (200 mg)
  • Guanabenz acetate salt,1-(2,6-Dichlorobenzylideneamino)guanidine acetate salt, WY-8678
  • [(2,6-dichlorobenzylidene)amino]-Guanidine monoacetate
  • Wytensin
  • FLA-137
  • 1-(2,6-Dichlorobenzylideneamino)guanidine acetate salt, WY-8678
  • GUANABENZACETATE,USP
  • guanabenz acetate salt
  • 1-(2,6-dichlorobenzylideneamino)guanidine acetate salt
  • 3-[(2,6-dichlorophenyl)methylene]carbazamidine monoacetate
  • GUANABENZ ACETATE
  • [(2,6-DICHLOROBENZYLIDENE)AMINO]GUANIDINE ACETATE
  • [2,6-DICHLOROBENZYLIDENE)-AMINO]GUANIDINE
  • WY-8678

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