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Imidazolidinyl urea

CAS No.39236-46-9
Chemical Name:Imidazolidinyl urea
CBNumber:CB3426267
Molecular Formula:C11H16N8O8
Formula Weight:388.29
MOL File:39236-46-9.mol

Imidazolidinyl urea Property

Melting point 141-143℃
Boiling point 514.04°C (rough estimate)
Density 1.4245 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.6910 (estimate)
storage temp. 2-8°C
solubility Soluble in water and in glycerol, but insoluble in almost all organic solvents.
pka 7.41±0.10(Predicted)
form Liquid
color Clear
Water Solubility soluble
Merck 14,4916
Stability Stable.
InChIKey ZCTXEAQXZGPWFG-UHFFFAOYSA-N
LogP 0.9 at 20℃
CAS DataBase Reference 39236-46-9(CAS DataBase Reference)
FDA UNII M629807ATL
EPA Substance Registry System Imidurea (39236-46-9)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xi
Risk Statements :36
Safety Statements :26-36
WGK Germany :2
RTECS :YT7365000
TSCA :Yes
HS Code :29332990

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H317
Precautionary statements P280

Imidazolidinyl urea Price More Price(7)

Brand: Sigma-Aldrich(India)
Product number: I5133
Product name : Imidazolidinyl urea
Purity:
Packaging: 25G
Price: ₹4156.8
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: PHR1500
Product name : Imidurea
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1G
Price: ₹8995.58
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: I5133
Product name : Imidazolidinyl urea
Purity:
Packaging: 100G
Price: ₹8270.3
Updated: 2022/06/14
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Brand: TCI Chemicals (India)
Product number: I0665
Product name : Imidazolidinyl Urea
Purity:
Packaging: 25G
Price: ₹3100
Updated: 2022/05/26
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Brand: ALFA India
Product number: ALF-H60729-22
Product name : Imidazolidinyl urea
Purity:
Packaging: 100g
Price: ₹7575
Updated: 2022/05/26
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Imidazolidinyl urea Chemical Properties,Usage,Production

Chemical Properties Imidazolidinyl urea is a stable white, free-flowing odorless powder with a mild odour. It does not absorb ultraviolet light, and decomposes at temperatures above 160°C (Sheppard and Wilson, 1974). In aqueous solution the pH is close to neutrality. It is mainly contained in cosmetics and liquid soaps.
Uses imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place). generally, imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.
Production Methods Imidurea is produced by the condensation of allantoin with formaldehyde.
Definition ChEBI: Imidazolidinyl urea is a member of ureas. It has a role as an antimicrobial agent. It is an antimicrobial preservative used in cosmetics. It acts as a formaldehyde releaser.
General Description Imidazolidinyl Urea is a non-aromatic, polar, hydrophilic antimicrobial compound. It is used as a preservative in a variety of applications, most notably in personal care products and cosmetics. It is effective against a broad spectrum of bacteria, fungi and yeast. It is used as a preservative in cosmetics, shampoos, deodorants, body lotions, and in some therapeutic topical ointments and creams.
Flammability and Explosibility Non flammable
Pharmaceutical Applications N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is a broad-spectrum antimicrobial preservative used in cosmetics and topical pharmaceutical formulations; typical concentrations used are 0.03–0.5% w/w. It is effective between pH 3–9 and is reported to have synergistic effects when used with parabens.
Contact allergens Imidazolidinyl urea, a formaldehyde releaser related to diazolidinyl urea (see above), is used as an antimicrobial agent very active against Gram-positive and Gram-negative bacteria, used as a synergist in combination with para- bens. It is used as a preservative in aqueous products, mainly in cosmetics, toiletries, and liquid soaps.
Safety Imidurea is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. However, there have been some reports of contact dermatitis associated with imidurea, although these are relatively few considering its widespread use in cosmetics. Although imidurea releases formaldehyde, it does not appear to be associated with cross-sensitization with formaldehyde or other formaldehyde-releasing compounds.
LD50 (mouse, oral): 7.2 g/kg
LD50 (rabbit, skin): > 8 g/kg
LD50 (rat, oral): 11.3 g/kg
storage Imidurea is hygroscopic and should be stored in a well-closed container in a cool, dry place.
Incompatibilities N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is incompatible with strong oxidants. It is compatible with other preservatives including sorbic acid and quaternary ammonium compounds. It is also compatible with other pharmaceutical and cosmetic excipients including proteins, nonionic surfactants, and lecithin.
Regulatory Status Included in the FDA Inactive Ingredients Database (topical preparations). Accepted for use in cosmetics in Europe and the USA. Included in the Canadian List of Acceptable Non-medicinal Ingredients.