| Appearance |
solid with a mild odour |
| Melting point |
141-143℃ |
| Boiling point |
514.04°C (rough estimate) |
| density |
1.4245 (rough estimate) |
| vapor pressure |
0Pa at 25℃ |
| refractive index |
1.6910 (estimate) |
| storage temp. |
2-8°C
|
| solubility |
Soluble in water and in glycerol, but insoluble in almost
all organic solvents. |
| form |
Liquid |
| pka |
7.41±0.10(Predicted) |
| color |
Clear |
| Stability: |
Stable. |
| Water Solubility |
soluble |
| Merck |
14,4916 |
| Major Application |
pharmaceutical (small molecule) |
| Cosmetics Ingredients Functions |
PRESERVATIVE |
| Cosmetic Ingredient Review (CIR) |
Imidazolidinyl urea (39236-46-9) |
| InChI |
1S/C11H16N8O8/c20-2-18-4(6(22)16-10(18)26)14-8(24)12-1-13-9(25)15-5-7(23)17-11(27)19(5)3-21/h4-5,20-21H,1-3H2,(H2,12,14,24)(H2,13,15,25)(H,16,22,26)(H,17,23,27) |
| Contact allergens |
Imidazolidinyl urea, a formaldehyde releaser related to
diazolidinyl urea (see above), is used as an antimicrobial
agent very active against Gram-positive and Gram-negative
bacteria, used as a synergist in combination with para-
bens. It is used as a preservative in aqueous products,
mainly in cosmetics, toiletries, and liquid soaps.
|
| InChIKey |
ZCTXEAQXZGPWFG-UHFFFAOYSA-N |
| SMILES |
OCN1C(NC(=O)NCNC(=O)NC2N(CO)C(=O)NC2=O)C(=O)NC1=O |
| LogP |
0.9 at 20℃ |
| Uses |
imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place). generally, imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.
|
| CAS DataBase Reference |
39236-46-9(CAS DataBase Reference) |
| EPA Substance Registry System |
39236-46-9(EPA Substance) |
