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TYRPHOSTIN RG 13022

TYRPHOSTIN RG 13022 Structure
TYRPHOSTIN RG 13022
  • CAS No.136831-48-6
  • Chemical Name:TYRPHOSTIN RG 13022
  • CBNumber:CB9417056
  • Molecular Formula:C16H14N2O2
  • Formula Weight:266.29
  • MOL File:136831-48-6.mol
TYRPHOSTIN RG 13022 Property
  • Melting point 116.0 to 120.0 °C
  • Boiling point 423.8±45.0 °C(Predicted)
  • Density 1.172±0.06 g/cm3(Predicted)
  • storage temp. Keep in dark place,Sealed in dry,2-8°C
  • solubility DMSO or ethanol: soluble
  • pka 3.03±0.12(Predicted)
  • form White solid.
  • color White to Yellow to Green
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
  • HS Code  :2933.39.9200
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P280-P301+P312-P302+P352-P305+P351+P338
TYRPHOSTIN RG 13022 Price More Price(2)
  • Brand: TCI Chemicals (India)
  • Product number: T3575
  • Product name : Tyrphostin RG 13022
  • Purity: min. 98.0 %
  • Packaging: 25MG
  • Price: ₹8700
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: T3575
  • Product name : Tyrphostin RG 13022
  • Purity: min. 98.0 %
  • Packaging: 100MG
  • Price: ₹26000
  • Updated: 2022/05/26
  • Buy: Buy

TYRPHOSTIN RG 13022 Chemical Properties,Usage,Production

  • Uses RG-13022 is an epidermal growth factor (EGF) inhibitor and PDGF receptor tyrosine kinases.
  • Biological Activity rg13022 is a egfr tyrosine kinase inhibitor.increased expression of various growth factor receptors including egfr has been observed in human tumours. one therapeutic strategy for overcoming egf autocrine control of tumour growth is to inhibit egfr protein tyrosine kinase.
  • in vitro rg13022 had a dose-dependent, antiproliferative effect on gastric cell lines when grown either in serum-free conditions or in the presence of fcs. western blotting showed that rg13022 treatment led to an inhibition of the egfr phosphorylation in a431 cells and both egfr and c-erbb-2 in mkn45 cells. furthermore, investigation of intracellular signalling pathways suggested that alterations in intracellular signalling were responsible for the actions of rg 13022 in these cells [1].
  • in vivo in rats, rg13022 showed rapid bi-exponential elimination from plasma with a terminal half-life of 50.4 min. rg13022 plasma concentrations were less than 1 μm by 20 min after injection. in addition, rg13022 had no influence on the growth of hn5 tumours when administered chronically, starting either on the tumour inoculation day or after establishment of tumour xenografts. the rapid in-vivo elimination of rg13022 had potential significance to its development, as plasma concentrations fell below that required for in-vitro activity by 20 min after injection [2].
  • IC 50 5 μm for egfr
  • References [1] mclaughlin m,brunton v,morrison v,rae a,cooke t,bartlett j. growth inhibition of gastric cancer cell lines by the tyrphostin rg13022 and its effects on intracellular signalling. int j oncol.1996 mar;8(3):589-96.
    [2] mcleod hl,brunton vg,eckardt n,lear mj,robins dj,workman p,graham ma. in vivo pharmacology and anti-tumour evaluation of the tyrphostin tyrosine kinase inhibitor rg13022. br j cancer.1996 dec;74(11):1714-8.
TYRPHOSTIN RG 13022 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN RG 13022 Suppliers
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TYRPHOSTIN RG 13022 Spectrum
136831-48-6, TYRPHOSTIN RG 13022Related Search:
  • 抑制剂
  • 生化试剂
  • 细胞生物学试剂
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Epidermal Growth Factor Receptor (EGFR)
  • Kinase/Phosphatase Biology
  • Receptor Tyrosine Kinase Inhibitors
  • 化合物RG 13022,10 MM DMSO 溶液
  • 3-(3,4-二甲氧基苯基)-2-(吡啶-3-基)丙烯腈
  • 化合物RG 13022
  • TYROSINE KINASE抑制剂(RG13022)
  • 酪氨酸磷酸化抑制剂RG 13022
  • 136831-48-6
  • RG13022, 10 mM in DMSO
  • R 13022
  • HER1,Tyrphostin RG 13022,Inhibitor,RG13022,EGFR,Tyrphostin RG-13022,inhibit,ErbB-1,RG-13022,Epidermal growth factor receptor
  • 3-Pyridineacetonitrile, α-[(3,4-dimethoxyphenyl)methylene]-
  • RG13022, >98%
  • RG13022;RG 13022
  • 2-(3,4'-DIMETHOXYPHENYL)-1-(3''-PYRIDINYL)ACRYLONITRILE
  • TYRPHOSTIN RG 13022
  • RG-13022
  • ALPHA-(3'-PYRIDYL)-(3,4-DIMETHOXY)CINNAMONITRILE
  • 3-Pyridineacetonitrile,a-[(3,4-dimethoxyphenyl)methylene]-
  • 3-(3,4-dimethoxyphenyl)-2-(pyridin-3-yl)acrylonitrile
  • α-(3-Pyridyl)-3,4-dimethoxybenzeneacrylonitrile
  • 3-(3,4-Dimethoxyphenyl)-2-(3-pyridinyl)propenenitrile

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