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TYRPHOSTIN B46

TYRPHOSTIN B46 Structure
TYRPHOSTIN B46
  • CAS No.133550-34-2
  • Chemical Name:TYRPHOSTIN B46
  • CBNumber:CB5469835
  • Molecular Formula:C19H18N2O3
  • Formula Weight:322.36
  • MOL File:133550-34-2.mol
TYRPHOSTIN B46 Property
  • Boiling point 621.1±55.0 °C(Predicted)
  • Density 1.273±0.06 g/cm3(Predicted)
  • storage temp. Inert atmosphere,Store in freezer, under -20°C
  • solubility DMSO or ethanol: soluble
  • form Powder
  • pka 8.82±0.10(Predicted)
  • color Light yellow to yellow
Safety
  • Safety Statements  :22-24/25
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P280-P305+P351+P338

TYRPHOSTIN B46 Chemical Properties,Usage,Production

  • Description AG-555 is a tyrphostin inhibitor of the EGF receptor (EGFR; IC50 = 0.7 μM). It selectively inhibits EFGR over ErbB2 (IC50 = 35 μM). AG-555 inhibits EGF-dependent growth of HER 14 cells (IC50 = 2.5 μM) as well as the growth of psoriatic keratinocytes isolated from patients with psoriasis when used at concentrations ranging from 1 to 50 μM. It also inhibits Moloney murine leukemia virus (Mo-MuLV) reverse transcriptase activity (IC50 = 10.8 μM) without affecting Mo-MuLV-infected NIH3T3 cell growth (IC50 = 210 μM).
  • Uses Inhibitor of EGF receptor kinase activity
  • Biological Activity Potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC 50 = 0.7 μ M) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Induce G 1 growth arrest selectively in transformed cells (IC 50 values are 6.4 and 9.4 μ M in HPV16-immortalized and normal keratinocytes respectively).
  • IC 50 EGFR
  • References [1]. ben-bassat h, rosenbaum-mitrani s, hartzstark z, et al. inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes. cancer res, 1997, 57(17): 3741-3750.
    [2]. kleinberger-doron n, shelah n, capone r, et al. inhibition of cdk2 activation by selected tyrphostins causes cell cycle arrest at late g1 and s phase. exp cell res, 1998, 241(2): 340-351.
    [3]. sion-vardy n, vardy d, rodeck u, et al. antiproliferative effects of tyrosine kinase inhibitors (tyrphostins) on human bladder and renal carcinoma cells. j surg res, 1995, 59(6): 675-680.
    [4]. seri i, aflalo e, gazit a, et al. tyrphostin ag-555 inhibits early and late stages of moloney murine leukemia virus replication cycle. int j oncol, 1997, 10(6): 1185-1189.
TYRPHOSTIN B46 Preparation Products And Raw materials
Raw materials
Preparation Products
TYRPHOSTIN B46 Suppliers
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TYRPHOSTIN B46 Spectrum
133550-34-2, TYRPHOSTIN B46Related Search:
  • Intracellular Signaling
  • Protein Kinase
  • 抑制剂
  • 药靶配体
  • Receptor Tyrosine Kinase Inhibitors
  • Epidermal Growth Factor Receptor (EGFR)
  • Kinase/Phosphatase Biology
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • 化合物AG 555,10 MM DMSO 溶液
  • AG 555 (TYRPHOSTIN B46),EGFR-TYROSINE KINASE抑制剂
  • AG 555(TYRPHOSTIN B46),抑制剂
  • 化合物AG 555
  • (E)-2-氰基-3-(3,4-二羟基苯基)-N-(3-苯基丙基)丙烯酰胺
  • 133550-34-2
  • AG 555, 10 mM in DMSO
  • AG 555 (Tyrphostin B46), EGFR-tyrosine kinase inhibitor
  • TyrphostinB46 A 555
  • TyrphostinB46 AG 555
  • Tyrphostin AG-555,EGFR,Reverse Transcriptase,Bovine,Tyrphostin AG555,HER1,BPV,ErbB-1,Inhibitor,AG 555,Epidermal growth factor receptor,AG-555,AG555,inhibit,antiretroviral,Papillomavirus
  • (E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)acrylamide
  • AG555（Tyrphostin B46）
  • TYRPHOSTIN AG 555, >98%
  • AG 555, >98%
  • TYRPHOSTIN AG 555;TYRPHOSTIN AG-555;TYRPHOSTIN AG555
  • 2-Propenamide,2-cyano-3-(3,4-dihydroxyphenyl)-N-(3-phenylpropyl)-, (2E)-
  • AG 555 (Tyrphostin AG 555)
  • Tyrphostin B46, N-(3μ-Phenylpropyl)-3,4-dihydroxybenzylidenecyanoacetamide
  • ALPHA-CYANO-(3,4-DIHYDROXY)-N-(3-PHENYLPROPYL)CINNAMIDE
  • AG 555
  • (E)-2-CYANO-3-(3,4-DIHYDROXYPHENYL)-N-(3-PHENYLPROPYL)-2-PROPENAMIDE
  • TYRPHOSTIN B46
  • TYRPHOSTIN AG 555
  • N-(3'-PHENYLPROPYL)-3,4-DIHYDROXYBENZYLIDENECYANOACETAMIDE
  • N-(3-PHENYLPROPYL)-3,4-DIHYDROXY-ALPHA CYANOCINNAMIDE

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