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ATRACTYLOSIDE POTASSIUM SALT

ATRACTYLOSIDE POTASSIUM SALT Structure
ATRACTYLOSIDE POTASSIUM SALT
  • CAS No.102130-43-8
  • Chemical Name:ATRACTYLOSIDE POTASSIUM SALT
  • CBNumber:CB9377631
  • Molecular Formula:C30H47KO16S2
  • Formula Weight:766.91
  • MOL File:102130-43-8.mol
ATRACTYLOSIDE POTASSIUM SALT Property
  • Melting point 234-238°C
  • storage temp. Sealed in dry,2-8°C
  • solubility H2O: 20 mg/mL
  • form Solid
  • color Pale Brown to Pale Beige
  • Stability Hygroscopic
Safety
  • Hazard Codes  :T
  • Risk Statements  :23/24/25
  • Safety Statements  :36/37-45
  • RIDADR  :UN 2811 6.1/PG 2
  • WGK Germany  :3
  • HazardClass  :6.1(a)
  • PackingGroup  :I
  • HS Code  :2938909090
  • NFPA 704:
    0
    4 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H301+H311+H331
  • Precautionary statements P312-P260-P280

ATRACTYLOSIDE POTASSIUM SALT Chemical Properties,Usage,Production

  • Description Atractyloside is a natural heteroglucoside produced in some plants, including A. gummifera. Atractyloside prevents mitochondrial ATP synthesis by inhibiting ADP/ATP translocases, which are responsible for the exchange of adenine di- and triphosphates across the inner mitochondrial membrane.
  • Uses Atractyloside Dipotassium Salt is an inhibitor of ANT and apoptosis inducer.
  • in vivo

    Atractyloside (2-4 mg/kg, i.p., 2 weeks before feeding duration ends) potassium salt protects mice against liver steatosis by activation of autophagy via ANT-AMPK-mTORC1 signaling pathway[13].
    Atractyloside (50 mg/kg, i.p.) potassium salt produces a tubular nephrosis 180 min after its administration in male albino rats[14].

    Animal Model:Male ICR wide-type (WT) mice (feed with a high-fat diet (HFD))[13]
    Dosage:2, 4 mg/kg
    Administration:Intraperitoneal injection (i.p.), 2 weeks before the feeding duration ends
    Result:Reversed the changes of body weight, RW of liver and epididymal fat, and the serum AST level.
    Improved the NAFLD steatosis and decrease HFD-induced lipid accumulation in the liver.
    Decreased the protein expression of p-mTOR and the value of p-mTOR/mTOR.
    Increased the protein expression of LC3A/B-Ⅱ and ATG7.
    Increased amount of colocalization of LC3B and PLIN2.
  • References [1]. yamaguchi n, kagari t, kasai m. inhibition of the ryanodine receptor calcium channel in the sarcoplasmic reticulum of skeletal muscle by an adp/atp translocase inhibitor, atractyloside. biochem biophys res commun, 1999, 258(2): 247-251.
    [2]. pick-kober kh, schneider f. proliferation, macromolecular synthesis and energy metabolism of in vitro grown ehrlich ascites tumor cells after inhibition of atp-adp translocation by atractyloside. eur j cell biol, 1984, 34(2): 323-329.
    [3]. malekova l, kominkova v, ferko m, et al. bongkrekic acid and atractyloside inhibits chloride channels from mitochondrial membranes of rat heart. biochim biophys acta, 2007, 1767(1): 31-44.
ATRACTYLOSIDE POTASSIUM SALT Preparation Products And Raw materials
Raw materials
Preparation Products
ATRACTYLOSIDE POTASSIUM SALT Suppliers
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ATRACTYLOSIDE POTASSIUM SALT Spectrum
102130-43-8, ATRACTYLOSIDE POTASSIUM SALTRelated Search:
  • Nitric Oxide and Cell Stress
  • Mitochondrial Inhibitors
  • Cell Stress
  • reference standards from Chinese medicinal herbs (TCM).
  • phytochemical
  • pharmaceutical intermediate
  • herbal extract
  • chemical reagent
  • standard substance
  • reagent
  • 萜类
  • 抑制剂
  • 试剂
  • 药靶配体
  • 标准品，对照品
  • 标准品 -中药标准品
  • 对照品
  • 植物提取物
  • 对照品，标准品，植物单体，植物化合物
  • 标准品
  • C30H44O16S22K
  • 苍术苷钾盐,10 MM DMSO 溶液
  • 苍术苷二钾盐(标定对照品)
  • 苍术苷二钾盐(苍术苷钾盐,苍术苷) (以CAS报价为准)
  • (2R,4AR,6AR,7S,9R,11AS,11BR)-7-羟基-2-(((2R,3R,4R,5R,6R)-6-(羟甲基)-3-((3-甲基丁酸)氧基)-5-(磺酸基氧基)-4-(磺酸基氧基)四氢-2H-吡喃-2-基)氧基)-11B-甲基-8-亚甲基十四氢-6A,9-甲桥环庚烯并[A]萘-4-羧酸钾
  • 白术苷钾盐
  • 苍术苷对照品
  • 苍术苷标准品
  • 苍术苷二钾盐(分析标准品)
  • 苍术苷二钾盐,苍术苷钾盐,苍术苷
  • 苍术苷二钾盐
  • 苍术苷
  • 102130-43-8
  • Atractyloside potassium salt, 10 mM in DMSO
  • Atractylic acid dipotassium salt
  • Potassium (2R,4aR,6aR,7S,9R,11aS,11bR)-7-hydroxy-2-(((2R,3R,4R,5R,6R)-6-(hydroxymethyl)-3-((3-methylbutanoyl)oxy)-5-(sulfonatooxy)-4-(sulfooxy)tetrahydro-2H-pyran-2-yl)oxy)-11b-methyl-8-methylenetetradecahydro-6a,9-methanocyclohepta[a]naphthalene-4-carbox
  • bis(potassium salt)
  • (1S,4R,7R,9S,10S,13R,15S)-15-hydroxy-7-[(2R,3R,4R,5R,6R)-6-(hydroxymethyl)-3-(3-methylbutanoyloxy)-4,5-disulfooxy-tetrahydropyran-2-yl]oxy-9-methyl-14-methylene-tetracyclo[11.2.1.011o.0??]hexadecane-5-carboxylic acid
  • ATRACTYLOSIDE POTASSIUM SALT USP/EP/BP
  • Atractyloside dipotassium
  • 19-Norkaur-16-en-18-oic acid deriv. 1H-2,10a-Ethanophenanthrene
  • (2β,15α)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-19-Norkaur-16-en-18-oic Acid Dipotassium Salt
  • Atractyloside dipotassium salt, >=98%
  • 19-Norkaur-16-en-18-oicacid, 15-hydroxy-2-[[2-O-(3-Methyl-1-oxobutyl)-3,4-di-O-sulfo-b-D-glucopyranosyl]oxy]-,dipotassiuM salt, (2b,15a)- (9CI)
  • (2beta,15alpha)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl]oxy]-19-norkaur-16-en-18-oic acid dipotassium salt
  • 19-Norkaur-16-en-18-oic acid, 15-hydroxy-2-2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-.beta.-D-glucopyranosyloxy-, dipotassium salt, (2.beta.,15.alpha.)-
  • ATRACTYLOSIDE POTASSIUM SALT
  • ATRACTYLOSIDE, DIPOTASSIUM SALT, ATRACTYLIS GUMMIFERA
  • ATRACTYLOSIDE, DIPOTASSIUM SALT
  • ATR, 2K

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