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AC2-12

AC2-12 Structure
AC2-12
  • CAS No.256447-08-2
  • Chemical Name:AC2-12
  • CBNumber:CB9356865
  • Molecular Formula:C63H94N14O17S
  • Formula Weight:1351.57
  • MOL File:256447-08-2.mol
AC2-12 Property
  • storage temp. -20°C
  • form Solid
  • color White to off-white
  • biological source rabbit
  • Water Solubility Soluble to 1 mg/ml in 20% acetonitrile / Water
  • Sequence Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-OH
  • UNSPSC Code 12352203
  • NACRES NA.41
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
AC2-12 Price More Price(1)
  • Brand: Sigma-Aldrich(India)
  • Product number: SAB1306513
  • Product name : ANTI-ANNEXIN A1 (CENTER) antibody produced in rabbit
  • Purity: purified immunoglobulin, buffered aqueous solution
  • Packaging: 400μL
  • Price: ₹47796.6
  • Updated: 2022/06/14
  • Buy: Buy

AC2-12 Chemical Properties,Usage,Production

  • Uses Ac2-12, an annexin/lipocortin 1 (LC1)-mimetic peptide, inhibit neutrophil extravasation. Ac2-12 has antimigratory action and inhibits recruitment of neutrophils in experimental inflammation models[1][2].
  • Enzyme inhibitor This annexin/lipocortin-1 peptidomimetic (FW = 1351.58 g/mol; Sequence: Acetyl-AMVSEFLKQAW; CAS 256447-08-2; Soluble to 1 mg/mL in 20% (vol/vol) acetonitrile-H2O) markedly reduces the degree of neutrophil adhesion and emigration across mouse mesenteric postcapillary venules, when administered at 13 mg/kg (s.c.), but does not modify cell rolling, when assessed directly by intravital microscopy. Ac2-12 also promotes neutrophil detachment from mesenteric endothelium after activation by intraperitoneal injection of 1 mg zymosan in mice (i.e., zymosan peritonitis). Ac2-12 phenocopies the effects observed in FormylatedPeptide Receptor (FPR) knock-out mice.
  • in vivo

    Ac2-12 (i.v.; 6.7 mg/kg, ≈70 nmol per mouse), was found to mimic the actions of lipocortin 1 (LC1) and Ac2-26 in male Swiss Albino mice (10-15 g)[1].
    Ac2-12 (100 μg) significantly reduces polymorphonuclear leukocyte (PMN) influx in wild-type C57BL/6 mice and is no longer active in FPR KO mice[2].

  • References [1] L H Lim, et al. Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14535-9. DOI:10.1073/pnas.95.24.14535
    [2] M Perretti, et al. Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol. 2001 Jun;158(6):1969-73. DOI:10.1016/S0002-9440(10)64667-6
AC2-12 Preparation Products And Raw materials
Raw materials
Preparation Products
AC2-12 Suppliers
Global(87)Suppliers
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
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  • Supplier：
    Nanjing TGpeptide
  • Tel：+86-13347807150<br/>+86-13347807150
  • Email：support@tgpeptide.com
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  • Tel：821-50328103-801<br/>18930552037
  • Email：3bsc@sina.com
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  • Supplier： GL Biochem (Shanghai) Ltd
  • Tel：21-61263452<br/>13641803416
  • Email：ymbetter@glbiochem.com
  • Country：China
  • ProdList：9981
  • Advantage：64
AC2-12 Spectrum
256447-08-2, AC2-12Related Search:
  • peptide
  • 目录肽
  • 抗体-一抗
  • 多肽
  • C63H94N14O17S
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  • PE-CY7标记的膜粘连蛋白A1抗体
  • IRDYE 800CW标记的膜粘连蛋白A1抗体
  • BIOTIN标记的膜粘连蛋白A1抗体
  • CY7标记的膜粘连蛋白A1抗体
  • APC标记的膜粘连蛋白A1抗体
  • BF700标记的膜粘连蛋白A1抗体
  • CY3标记的膜粘连蛋白A1抗体
  • RBITC标记的膜粘连蛋白A1抗体
  • BF750标记的膜粘连蛋白A1抗体
  • HRP标记的膜粘连蛋白A1抗体
  • PE标记的膜粘连蛋白A1抗体
  • AP标记的膜粘连蛋白A1抗体
  • BF350标记的膜粘连蛋白A1抗体
  • PE-CY5.5标记的膜粘连蛋白A1抗体
  • APC-CY5.5标记的膜粘连蛋白A1抗体
  • CY5.5标记的膜粘连蛋白A1抗体
  • BF405标记的膜粘连蛋白A1抗体
  • BF594标记的膜粘连蛋白A1抗体
  • BF680标记的膜粘连蛋白A1抗体
  • BF488标记的膜粘连蛋白A1抗体
  • PE-CY5标记的膜粘连蛋白A1抗体
  • A287437] AC2-12,ANNEXIN / LIPOCORTIN 1类似物
  • ANTI-ANNEXIN A1 ANTIBODY -膜粘连蛋白A1抗体
  • 钙依赖性磷脂结合蛋白ANNEXIN A1 (1-11) (DEPHOSPHORYLATED)
  • AC-AW-11
  • 膜联蛋白-A1
  • 膜粘连蛋白A1单克隆抗体
  • 256447-08-2
  • Recombinant Human Annexin A1/ANXA1 Protein, No Tag
  • L-Tryptophan, N-acetyl-L-alanyl-L-methionyl-L-valyl-L-seryl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-lysyl-L-glutaminyl-L-alanyl-
  • Annexin A1 (1-11)
  • Annexin A1 (1-11) (dephosphorylated) (human, bovine, chicken, porcine) trifluoroacetate salt Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-OH trifluoroacetate salt
  • AC2-12
  • AC-ALA-MET-VAL-SER-GLU-PHE-LEU-LYS-GLN-ALA-TRP-OH
  • AC-AMVSEFLKQAW
  • ANXA-1
  • ANNEXIN 1
  • Annexin A1 (1-11) (dephosphorylated)
  • Annexin 1 (ANXA - 1
  • LPC1
  • ANX1
  • ANTI-ANNEXIN A1 (CENTER) antibody produced in rabbit
  • Annexin A1
  • Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine)
  • Annexin A1 (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine) Annexin-1 (2-12) (huMan, bovine, chicken, porcine), Lipocortin-1 (2-12), Calpactin II (1-11) (dephosphorylated) (huMan, bovine, chicken, porcine)

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