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AC2-26

AC2-26 Structure
AC2-26
  • CAS No.151988-33-9
  • Chemical Name:AC2-26
  • CBNumber:CB5429378
  • Molecular Formula:C141H210N32O44S
  • Formula Weight:3089.43
  • MOL File:151988-33-9.mol
AC2-26 Property
  • Boiling point 2847.6±65.0 °C(Predicted)
  • Density 1.327±0.06 g/cm3(Predicted)
  • storage temp. Desiccate at -20°C
  • solubility Soluble to 1 mg/ml in PBS
  • form Solid
  • color White to off-white
  • Sequence Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

AC2-26 Chemical Properties,Usage,Production

  • Uses Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model[1][2][3][4].
  • in vivo

    Ac2-26 (1?mg/kg/d, i.v. since reperfusion until day 7) reduces cardiac necrosis and cardiac inflammation in mice 24 h/48 h post I-R injury model[6].

  • storage Store at -20°C
  • References [1] Wang LM, et al. Annexin 1-derived peptide Ac2-26 inhibits eosinophil recruitment in vivo via decreasing prostaglandin D?. Int Arch Allergy Immunol. 2011;154(2):137-48. DOI:10.1159/000320228
    [2] Liu L, et al. Ac2-26 Induces IKKβ Degradation Through Chaperone-Mediated Autophagy Via HSPB1 in NCM-Treated Microglia. Front Mol Neurosci. 2018 Mar 15;11:76. DOI:10.3389/fnmol.2018.00076
    [3] Gong J, et al. Ac2-26 ameliorates lung ischemia-reperfusion injury via the eNOS pathway. Biomed Pharmacother. 2019 Sep;117:109194. DOI:10.1016/j.biopha.2019.109194
    [4] Luo Z, et al. Annexin-1 Mimetic Peptide Ac2-26 Suppresses Inflammatory Mediators in LPS-Induced Astrocytes and Ameliorates Pain Hypersensitivity in a Rat Model of Inflammatory Pain. Cell Mol Neurobiol. 2020 May;40(4):569-585. DOI:10.1007/s10571-019-00755-8
    [5] Zheng Y, et al. Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro. Inflamm Res. 2023 Feb;72(2):347-362. DOI:10.1007/s00011-022-01640-9
    [6] Qin CX, et al. Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction. Front Pharmacol. 2019 Apr 3;10:269. DOI:10.3389/fphar.2019.00269
AC2-26 Preparation Products And Raw materials
Raw materials
Preparation Products
AC2-26 Suppliers
Global(74)Suppliers
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    BOC Sciences
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    Cellmano Biotech Limited
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    TargetMol Chemicals Inc.
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AC2-26 Spectrum
151988-33-9, AC2-26Related Search:
  • 抑制剂
  • 目录肽
  • 目录多肽
  • C141H210N32O44S
  • AC2-26 |CAS 151988-33-9
  • 化合物 AC2-26
  • NF-ΚB 抑制剂:AC2-26
  • 钙依赖性磷脂结合蛋白ANNEXIN-1 (2-26) (HUMAN)
  • N-乙酰基-L-丙氨酰-L-蛋氨酰-L-缬氨酰-L-丝氨酰-L-ALPHA-谷氨酰-L-苯丙氨酰-L-亮氨酰-L-赖氨酰-L-谷氨酰胺酰-L-丙氨酰-L-色氨酰-L-苯丙氨酰-L-异亮氨酰-L-ALPHA-谷氨酰-L-天冬氨酰胺酰-L-ALPHA-谷氨酰T戊基-L-ALPHA-谷氨酰-L-谷氨酰胺酰-L-ALPHA-谷氨酰-L-酪氨酰-L-缬氨酰-L-谷氨酰胺酰-L-苏氨酰-L-缬氨酰-L-赖氨酸
  • AC-AK-25
  • 151988-33-9
  • Annexin A1(1-25)(dephosphorylated)(human)ammonium salt
  • Ac2-26 TFA salt
  • CA2-26
  • L-Lysine, N-acetyl-L-alanyl-L-methionyl-L-valyl-L-seryl-L-α-glutamyl-L-phenylalanyl-L-leucyl-L-lysyl-L-glutaminyl-L-alanyl-L-tryptophyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-asparaginyl-L-α-glutamyl-L-α-glutamyl-L-glutaminyl-L-α-glutamyl-L-tyrosyl-L-valyl-L-glutaminyl-L-threonyl-L-valyl-
  • Annexin A1 (1-25) (dephosphorylated) (human) trifluoroacetate salt Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH trifluoroacetate salt
  • Annexin 1 (ANXA - 1, Ac 2 - 26)
  • Annexin A1 (1-25)
  • AC2-26
  • Annexin-1 (2-26) (huMan), Lipocortin-1 (2-26), Calpactin II (1-25) (dephosphorylated) (huMan), Ac2-26
  • Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH
  • Annexin A1 (1-25) (dephosphorylated) (huMan) Annexin-1 (2-26) (huMan), Lipocortin-1 (2-26), Calpactin II (1-25) (dephosphorylated) (huMan), Ac2-26

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