ChemicalBook > CAS DataBase List > Diphenylpyraline Hydrochloride

Diphenylpyraline Hydrochloride

Diphenylpyraline Hydrochloride Structure
Diphenylpyraline Hydrochloride
  • CAS No.132-18-3
  • Chemical Name:Diphenylpyraline Hydrochloride
  • CBNumber:CB9356441
  • Molecular Formula:C19H24ClNO
  • Formula Weight:317.85
  • MOL File:132-18-3.mol
Diphenylpyraline Hydrochloride Property
  • Melting point 203-205 °C(lit.)
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly), Water (Slightly)
  • form Solid
  • color White to Off-White
  • Merck 13,3363
  • Stability Hygroscopic
  • EWG's Food Scores 1
  • FDA UNII G9FU7F1E87
  • EPA Substance Registry System Diphenylpyraline hydrochloride (132-18-3)
  • UNSPSC Code 12352100
  • NACRES NA.22
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :20/21/22-36/37/38-22
  • Safety Statements  :26-36
  • RIDADR  :3249
  • WGK Germany  :3
  • RTECS  :TM7823600
  • HazardClass  :6.1(b)
  • PackingGroup  :III
  • Toxicity :mouse,LD50,intramuscular,64300ug/kg (64.3mg/kg),Drugs in Japan Vol. 6, Pg. 333, 1982.
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302
  • Precautionary statements P280-P305+P351+P338
Diphenylpyraline Hydrochloride Price More Price(2)
  • Brand: Sigma-Aldrich
  • Product number: 280550
  • Product name : 4-Diphenylmethoxy-1-methylpiperidine hydrochloride
  • Purity: 95%
  • Packaging: 10G
  • Price: ₹6137.78
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 280550
  • Product name : 4-Diphenylmethoxy-1-methylpiperidine hydrochloride
  • Purity: 95%
  • Packaging: 10G
  • Price: ₹6137.78
  • Updated: 2022/06/14
  • Buy: Buy

Diphenylpyraline Hydrochloride Chemical Properties,Usage,Production

  • Description Diphenylpyraline is an antihistamine drug with anticholinergic and sedative action. It is intended for symptomatic treatment of seasonal allergies and allergic reactions as well as an adjuvant drug in anaphylactic reaction therapy. Synonyms of this drug are arbid, timpil, histryl, hispril, and others.
  • Originator Diafen,Riker,US,1955
  • Uses Antihistaminic;H1 antagonist
  • Uses Diphenylpyraline Hydrochloride is a salt of Diphenylpyraline (D492110), an H1 receptor antagonist (an antihistamine) and is commonly prescribed to treat allergic and vasomotor rhinitis. There is also some research being conducted on diphenylpyraline derivatives to determine their antimycobacterial and antifungal activity.
  • Definition ChEBI: The hydrochloride salt of diphenylpyraline. A sedating antihistamine, it is used as the hydrochloride for the symptomatic relief of allergic conditions including rhinitis and hay fever, and in pruritic skin disorders.
  • Manufacturing Process A mixture of 46 grams of 1-methyl-4-piperidinol (0.4 mol), 49.4 grams of benzhydryl
    omide (0.2 mol) and 100 ml of xylene was refluxed for approximately 24 hours. The reaction mixture separated into two phases with the upper phase containing the desired ether compound dissolved in xylene. The lower phase consisted of the hydro
    omide salt of the excess 1-methyl-4- piperidinol. The upper phase was separated from the lower phase and the desired benzhydryl ether recovered in the crude state by distilling off the xylene under reduced pressure.
    The crude benzhydryl ether was a clear reddish oil. It was dissolved in 75 ml of 20% hydrochloric acid and the aqueous acid solution then washed three times with 50 ml portions each of ethyl ether. The aqueous acid solution was then decolorized with activated carbon and thereafter slowly admixed with 75 ml of 28% aqueous ammonia. The benzhydryl ether separated as an oily material and was removed from the aqueous mixture by extraction with three 50 ml portions of ethyl ether.
    On evaporation of the ethyl ether from the ethyl ether solution, the benzhydryl ether was recovered as a pale yellow oil. The benzhydryl ether was dissolved in 60 ml of isopropanol and the isopropanol solution acidified to a pH of 3 with dry hydrogen chloride-methanol solution. The acidic propanol solution was then diluted with ethyl ether until a faint turbidity was observed. In a short time, the crystalline hydrochloride salt of the benzhydryl ether separated from the propanol solution. The crystallized salt was recrystallized once from 75 ml of isopropanol with the aid of ethyl ether in order to further purify the material. A yield of the pure hydrochloride salt of 1-methylpiperidyl- 4-benzhydryl ether of 24.5 grams was obtained. This was 39% of the theoretical yield. The pure material had a melting point of 206°C.
  • Therapeutic Function Antihistaminic
  • General Description Diphenylpyr alinehydrochloride, 4-(diphenylmethoxy)-1-methylpiperidinehydrochloride (Hispril, Diafen) is a white or slightly offwhitecrystalline powder that is soluble in water or alcohol.Diphenylpyraline is structurally related to diphenhydraminewith the aminoalkyl side chain incorporated in a piperidinering. It is a potent antihistaminic, and the usual dose is 2 mg3 or 4 times daily.
  • Synthesis Diphenylpyraline, 4-diphenylmethoxy-1-methylpiperidine (16.1.32), is synthesized by alkylating 4-hydroxy-1-methylpiperidine with benzhydrylbromide.

    Synthesis_132-18-3

Diphenylpyraline Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Diphenylpyraline Hydrochloride Suppliers
Global(92)Suppliers
  • Supplier：
    LEAP CHEM CO., LTD.
  • Tel：+86-852-30606658
  • Email：market18@leapchem.com
  • Country：China
  • ProdList：24727
  • Advantage：58
  • Supplier：
    Alchem Pharmtech,Inc.
  • Tel：8485655694
  • Email：sales@alchempharmtech.com
  • Country：United States
  • ProdList：63687
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Finetech Industry Limited
  • Tel：+86-27-87465837<br/>+8618971612321
  • Email：info@finetechnology-ind.com
  • Country：China
  • ProdList：9642
  • Advantage：58
  • Supplier：
    sgtlifesciences pvt ltd
  • Tel： +8617013299288
  • Email：dj@sgtlifesciences.com
  • Country：China
  • ProdList：12373
  • Advantage：58
Diphenylpyraline Hydrochloride Spectrum
132-18-3, Diphenylpyraline HydrochlorideRelated Search:
  • API intermediates
  • API
  • 高端化学
  • 医药中间体
  • 小分子抑制剂
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperidines
  • C19H24NOCl
  • C19H23NOHCl
  • 盐酸双苯比拉林,10 MM DMSO 溶液
  • 二苯吡咯啉盐酸盐
  • 盐酸二苯拉林
  • 4-二苯基甲氧基-1-甲基哌啶盐酸盐
  • 4-(二苯甲基氧基)-1-甲基哌啶盐酸盐
  • 4-二苯甲氧基-1-甲基哌啶二苯拉林盐酸盐
  • 盐酸双苯比拉林 标准品
  • 4-二苯甲氧基-1-甲基哌啶盐酸盐
  • 双苯比拉林 盐酸盐
  • 二苯拉林 盐酸盐
  • 4-二苯甲氧基-1-甲基哌啶
  • 盐酸双苯比拉林
  • 盐酸二苯比拉林
  • 132-18-3
  • Diphenylpyraline hydrochloride, 10 mM in DMSO
  • Parkinson’s disease,inhibit,Inhibitor,allergic,Histamine Receptor,pruritic skin disorders,Diphenylpyraline,rhinitis,hay fever,psychostimulant,Diphenylpyraline hydrochloride
  • 4-(benzhydryloxy)-1-methylpiperidine
  • 4-(diphenylmethyl)oxy-1-methylpiperidine
  • 4-(Diphenyl Methoxy)-1-piperidine HCl
  • 4-(Benzhydryloxy)-1-Methylpiperidine hydrochloride
  • 4-Diphenylmethoxy-1-methylpiperidine hydrochloride,4-Diphenylmethoxy-1-methylpiperidine, Diphenylpyraline hydrochloride
  • Hy-stamin
  • 4-Diphenylmethoxy-1-methylpiperidine, Diphenylpyraline hydrochloride
  • 4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE HCL
  • Diphenylpyraline hydrochlorid
  • Lergobine
  • 4-diphenylmethoxy-1-methylpiperidine
  • Piperidine, 4-(diphenylmethoxy)-1-methyl-, hydrochloride
  • 4-diphenylmethoxy-1-methylpiperidine hydrochlorid
  • 4-Benzhydryloxy-1-methylpiperidine~Diphenylpyraline hydrochloride
  • DIPHENYLPYRALINE HYDROCHLORIDE
  • DIPHENYLPYRALINE HCL
  • LABOTEST-BB LT00159897
  • 4-BENZHYDRYLOXY-1-METHYL PIPERIDINE HCL
  • 4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE HYDROCHLORIDE MONOHYDRATE
  • 4-DIPHENYLMETHOXY-1-METHYLPIPERIDINE HYDROCHLORIDE

Home

My