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Azido-PEG3-Sulfone-PEG4-acid

Azido-PEG3-Sulfone-PEG4-acid Structure
Azido-PEG3-Sulfone-PEG4-acid
  • CAS No.2055024-42-3
  • Chemical Name:Azido-PEG3-Sulfone-PEG4-acid
  • CBNumber:CB93162872
  • Molecular Formula:C19H37N3O11S
  • Formula Weight:515.58
  • MOL File:2055024-42-3.mol
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Azido-PEG3-Sulfone-PEG4-acid Chemical Properties,Usage,Production

  • Description Azido-PEG3-Sulfone-PEG4-acid is a PEG linker containing one azide group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.
  • Uses Azido-PEG3-Sulfone-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-Sulfone-PEG4-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG3-Sulfone-PEG4-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG3-Sulfone-PEG4-acid Suppliers
Global(18)Suppliers
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    TargetMol Chemicals Inc.
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    Nextpeptide Inc
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  • Supplier：
    Aladdin Scientific
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  • Email：tp@aladdinsci.com
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Azido-PEG3-Sulfone-PEG4-acid Spectrum
2055024-42-3, Azido-PEG3-Sulfone-PEG4-acidRelated Search:
  • 叠氮-三聚乙二醇-砜-四聚乙二醇-羧酸
  • AZIDO-三聚乙二醇-SULFONE-四聚乙二醇-羧酸
  • 2055024-42-3
  • 4,7,10,13,19,22,25-Heptoxa-16-thiaheptacosanoic acid, 27-azido-, 16,16-dioxide
  • Azido-PEG3-Sulfone-PEG4-acid

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