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Azido-PEG3-Sulfone-PEG4-t-butyl ester

Azido-PEG3-Sulfone-PEG4-t-butyl ester Structure
Azido-PEG3-Sulfone-PEG4-t-butyl ester
  • CAS No.2055023-76-0
  • Chemical Name:Azido-PEG3-Sulfone-PEG4-t-butyl ester
  • CBNumber:CB23162873
  • Molecular Formula:C23H45N3O11S
  • Formula Weight:571.6819
  • MOL File:2055023-76-0.mol
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Azido-PEG3-Sulfone-PEG4-t-butyl ester Chemical Properties,Usage,Production

  • Description Azido-PEG3-Sulfone-PEG4-t-butyl ester is a PEG linker containing one azide group and one t-butyl protected carboxyl group. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group (COOH) prevents self coupling or polymerization under standard acid/amine or acid/hydroxyl coupling conditions.
  • Uses Azido-PEG3-Sulfone-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-Sulfone-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
  • IC 50 PEGs
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG3-Sulfone-PEG4-t-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
Azido-PEG3-Sulfone-PEG4-t-butyl ester Suppliers
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Azido-PEG3-Sulfone-PEG4-t-butyl ester Spectrum
2055023-76-0, Azido-PEG3-Sulfone-PEG4-t-butyl esterRelated Search:
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  • 2055023-76-0
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  • Azido-PEG3-Sulfone-PEG4-Boc
  • Azido-PEG3-Sulfone-PEG4-t-butyl ester

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