ChemicalBook > CAS DataBase List > UNC3866
UNC3866
UNC3866
- CAS No.1872382-47-2
- Chemical Name:UNC3866
- CBNumber:CB93153225
- Molecular Formula:C43H66N6O8
- Formula Weight:795.02
- MOL File:1872382-47-2.mol
UNC3866 Property
- Boiling point 1034.5±65.0 °C(Predicted)
- Density 1.129±0.06 g/cm3(Predicted)
- storage temp. Sealed in dry,Store in freezer, under -20°C
- solubility Soluble in DMSO
- form A crystalline solid
- pka 13.39±0.46(Predicted)
- color White to off-white
-
Symbol(GHS)
- Signal wordWarning
- Hazard statements H302-H315-H319-H335
- Precautionary statements P261-P305+P351+P338
UNC3866 Chemical Properties,Usage,Production
- Description UNC3866 is an inhibitor of chromobox homolog 7 (CBX7; Kd = 97 nM). It also binds to CBX4 (Kd = 94 nM) but is greater than 6-fold selective over CBX2, 6, and 8 and the chromodomain Y family (CDY) chromodomains CDY1, L1b, and L2 (Kds = 0.61-6.3 μM). UNC3866 pretreatment (30 μM) of PC3 lysates completely inhibits chemiprecipitation of CBX7. It induces a senescent-like morphology and reduces growth of PC3 cells with an EC50 value of 7.6 μM.
- Uses Polycomb group proteins (CBX4, CBX7) regulate cell fate decisions during embryogenesis. N-?[4-?(1,?1-Dimethylethyl)?benzoyl]?-?L-?phenylalanyl-?L-?alanyl-?L-?leucyl-?N6,?N6-?diethyl-?L-?lysyl-?L-serine Methyl Ester is a selective antagonist of CBX4 and CBX7 chromodomains. It also inhibits prostate cell proliferation.
UNC3866 Preparation Products And Raw materials
Raw materials
Preparation Products
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1872382-47-2, UNC3866Related Search:
- 药靶配体
- 活性多肽
- 抑制剂
- C43H66N6O8
- 化合物UNC3866,10 MM DMSO 溶液
- (3S,6S,9S,12S,15S)-甲基 3-苄基-1-(4-(叔丁基)苯基)-12-(4-(二乙基氨基)丁基)-15-(羟甲基)-9-异丁基-6-甲基-1,4,7,10,13-五氧代-2,5,8,11,14-五氮杂十六烷-16-油酸
- 化合物UNC3866
- N-[4-(1,1-二甲基乙基)苯甲酰基]-L-苯丙氨酰基-L-丙氨酰基-L-亮氨酰-N6,N6-二乙基-L-赖氨酰-L-丝氨酸甲酯
- UNC3866游离态
- 1872382-47-2
- UNC3866, 10 mM in DMSO
- UNC3866,inhibit,Histone Methyltransferase,UNC-3866,Inhibitor,UNC 3866
- L-Serine, N-[4-(1,1-dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-, methyl ester
- (3S,6S,9S,12S,15S)-Methyl 3-benzyl-1-(4-(tert-butyl)phenyl)-12-(4-(diethylamino)butyl)-15-(hydroxymethyl)-9-isobutyl-6-methyl-1,4,7,10,13-pentaoxo-2,5,8,11,14-pentaazahexadecan-16-oate
- UNC 3866;UNC-3866
- CS-2491
- N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester
- UNC3866