UNC-1215

UNC-1215 Property

Safety

Hazard and Precautionary Statements (GHS)

UNC-1215 Price More Price(2)

UNC-1215 Chemical Properties,Usage,Production

Uses UNC 1215 is ; a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 binds the MBT domains of L3MBTL3 with a Kd of 120 nM, competitively displacing mono- or dimethyl-lysine containing peptides
Definition ChEBI: [3-anilino-4-[oxo-[4-(1-pyrrolidinyl)-1-piperidinyl]methyl]phenyl]-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone is a member of benzamides and a N-acylpiperidine.
Biological Activity UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. Lethal (3) malignant brain tumor-like protein 3 (L3MBTL3) is a putative polycomb group (PcG) protein with gene-repressing activity, a member of the MBT family of methyllysine binders. Methyl-lysine binding proteins are a family of proteins th at are important epigenetic regulators th at “read” the post-translational methylation state of histone lysine residues and modulate protein-protein interactions th at regulate gene expression. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. UNC1215 showed a significant decrease in FRAP recovery (Fluorescence Recovery After Photobleaching) time below 1 microM in cells using GFP-L3MBTL3. For full characterization details, please visit the UNC1215 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
target L3MBTL3

UNC-1215 Preparation Products And Raw materials

Raw materials

Preparation Products

UNC-1215 Suppliers

Global(132)Suppliers

UNC-1215 Spectrum

1415800-43-9, UNC-1215Related Search:

Inhibitors
抑制剂
生物试剂
合成有机化合物配体
小分子抑制剂
小分子抑制剂，天然产物
C32H43N5O2
1,1'-[2-(苯基氨基)-1,4-亚苯基]二[1-[4-(1-吡咯烷基)-1-哌啶基]甲酮]
化合物UNC1215,10 MM DMSO 溶液
UNC1215,L3MBTL3 甲基赖氨酸结构域的拮抗剂
(2-(苯氨基)-1,4-亚苯基)双((4-(吡咯烷-1-基)哌啶-1-基)甲酮)
化合物UNC1215
1,1'-[2-(苯基氨基)-1,4-亚苯基]二[1-[4-(1-吡咯烷基)-1-哌啶基]甲酮]
1415800-43-9
UNC1215, 10 mM in DMSO
N-Phenyl-2,5-bis({[4-(pyrrolidin-1-yl)piperidin-1-yl]carbonyl})aniline
CS-714
UNC 1215; UNC1215
UNC-1215 USP/EP/BP
[2-Phenylamino-4-(4-pyrrolidin-1-yl-piperidine-1-carbonyl)-phenyl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone
1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone] UNC 1215
Methanone, 1,1'-[2-(phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]-
UNC1215 1,1'-[2-(PhenylaMino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]Methanone]
UNC 1215, >=98%
1,1'-[2-(Phenylamino)-1,4-phenylene]bis[1-[4-(1-pyrrolidinyl)-1-piperidinyl]methanone]
(2-(phenylaMino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)Methanone)
UNC-1215
UNC1215
UNC 1215