UNC569

UNC569 Property

storage temp. Store at -20°C
solubility DMF: 2.5 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml; DMSO: 0.2 mg/ml; Ethanol: 2 mg/ml
form A crystalline solid
color White to yellow

Hazard and Precautionary Statements (GHS)

UNC569 Chemical Properties,Usage,Production

Uses UNC 569 induces morphological changes in pigment epithelia and photoreceptor cells in retina through MerTK inhibition in mice. A specific MerTK inhibitor.
in vivo
The in vivo pharmacokinetic properties of UNC569 (3 mg/kg) are also assessed in mice via both intravenous (IV) and oral (PO) administration. UNC569 has low systemic clearance (19.5 mL/min/kg), high volume of distribution (V_ss of 5.83 L/kg), and good oral bioavailability (57%)^[1].
Leukemic zebrafish are treated continuously for 2 weeks by immersion in 4 μM UNC569. the result shows that UNC569 induces more than 50% reduction in tumor burden compared with vehicle- and mock-treated fish^[2].
IC 50 Axl; Tyro3; Mer

UNC569 Preparation Products And Raw materials

Raw materials

Preparation Products

UNC569 Suppliers

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UNC569 Spectrum

1350547-65-7, UNC569Related Search:

抑制剂
C22H29FN6
化合物UNC569,10 MM DMSO 溶液
标准品/UNC569
1-((反式-4-氨基环己基)甲基)-N-丁基-3-(4-氟苯基)-1H-吡唑并[3,4-D]嘧啶-6-胺
化合物UNC569
1350547-65-7
UNC569, 10 mM in DMSO
N-butyl-3-(4-fluorophenyl)-1-{[(1r,4r)-4-aminocyclohexyl]methyl}-1H-pyrazolo[3,4-d]pyrimidin-6-amine
1-((trans-4-Aminocyclohexyl)methyl)-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine
anti-oncogenic,Inhibitor,ATP-competitive,ALL,UNC-569,UNC569,Tyro3,AKT,TAM Receptor,ERK,Mer,inhibit,pyrazolopyrimidine,Axl
UNC-569;UNC 569
CS-2399
1H-Pyrazolo[3,4-d]pyrimidin-6-amine, 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-
UNC569