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UNC3230

UNC3230 Structure
UNC3230
  • CAS No.1031602-63-7
  • Chemical Name:UNC3230
  • CBNumber:CB63067589
  • Molecular Formula:C17H20N4O2S
  • Formula Weight:344.43
  • MOL File:1031602-63-7.mol
UNC3230 Property
  • storage temp. Store at -20°C
  • solubility DMSO:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
    DMF:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
    Ethanol:0.2(Max Conc. mg/mL);0.58(Max Conc. mM)
  • form A crystalline solid
  • color Off-white to light yellow
  • UNSPSC Code 12352200
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

UNC3230 Chemical Properties,Usage,Production

  • Description Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG). Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2. UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM). It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases. At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.
  • Uses UNC 3230 is a potent inhibitor of PIP5K1C.
  • in vivo

    UNC3230 (2 nmol) significantly increases noxious heat-evoked paw withdrawal latency for two hours after intrathecal injection in wild-type mice, indicating an antinociceptive effect[1].
    UNC3230 (2 nmol; intrathecal injection) is administered then one hour later co-injected 1 nmol LPA with UNC3230 (2 nmol, intrathecal injection). UNC3230 significantly blunts thermal hyperalgesia and mechanical allodynia compared to vehicle[1].
    UNC3230 (2 nmol; intrathecal injection) significantly blunts thermal hyperalgesia and mechanical allodynia in the complete Freund’s adjuvant (CFA)-inflamed hindpaw (relative to vehicle control) but does not affect thermal or mechanical sensitivity in the control (non-inflamed) hindpaw over a multiday time course[1].

  • storage Store at +4°C
UNC3230 Preparation Products And Raw materials
Raw materials
Preparation Products
UNC3230 Suppliers
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    BOC Sciences
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    Aladdin Scientific
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UNC3230 Spectrum
1031602-63-7, UNC3230Related Search:
  • 酶
  • 抑制剂
  • 化合物UNC 3230,10 MM DMSO 溶液
  • UNC 3230,PIP5K1C抑制剂
  • 化合物UNC 3230
  • 5-(环己烷甲酰胺基)-2-(苯基氨基)噻唑-4-甲酰胺
  • 1031602-63-7
  • UNC3230, 10 mM in DMSO
  • hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor
  • 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide
  • 4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-
  • 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
  • 2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide
  • UNC3230

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