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Carbenoxolone

Carbenoxolone Structure
Carbenoxolone
  • CAS No.5697-56-3
  • Chemical Name:Carbenoxolone
  • CBNumber:CB9314814
  • Molecular Formula:C34H50O7
  • Formula Weight:570.76
  • MOL File:5697-56-3.mol
Carbenoxolone Property
Safety
  • Toxicity :LD50 orl-rat: 2450 mg/kg OYYAA2 19,323,80
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

Carbenoxolone Chemical Properties,Usage,Production

  • Originator Biogastrone,Winthrop,UK,1963
  • Uses Glucocorticoid.
  • Manufacturing Process 23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by 30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry pyridine. The solution was heated on a boiling water bath for ten hours and then poured into excess of dilute hydrochloric acid and ice. The fine gray precipitate formed was filtered off, washed with water, dissolved in chloroform, and the solution repeatedly extracted with dilute hydrochloric acid and later with water. It was dried over sodium sulfate and evaporated to dryness. Crystallization from methanol, using charcoal to effect decolorization, gave the hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with previous softening.
    One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. The solution was filtered and evaporated in vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from licorice root.
  • Therapeutic Function Antiinflammatory (gastric)
  • Safety Profile Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion andsubcutaneous routes. Human systemic effects byingestion: muscle weakness and flaccid paralysis. Whenheated to decomposition it emits acrid smoke and fumes.
Carbenoxolone Preparation Products And Raw materials
Raw materials
Preparation Products
Carbenoxolone Suppliers
Global(120)Suppliers
  • Supplier：
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Carbenoxolone Spectrum
5697-56-3, CarbenoxoloneRelated Search:
  • Pentacyclic Triterpenes
  • 化工试剂
  • 植物提取类
  • 医药、农药及染料中间体
  • 医药原料药
  • 原料药
  • 化合物：原料药
  • 标准品
  • 中药对照品
  • 植提
  • 植物提取物
  • 医药原料
  • 五环三萜
  • 中草药成分
  • C34H50O7
  • (2S,4AS,6AS,6BR,8AR,10S,12AS,12BR,14BR)-10-((3-羧基丙酰基)氧基)-2,4A,6A,6B,9,9,12A-七甲基-13-氧代-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-二十氢苉-2-羧酸
  • 3-(3-羧基)丙酰基甘草次酸
  • 甘珀酸-D4
  • ⅡA-1(甘草次酸)
  • 生胃酮钠
  • 生胃酮
  • 卡贝索酮钠
  • 甘珀酸
  • 甘珀酸/甘草次酸
  • 甘皮酸钠
  • 5697-56-3
  • Carbenoxolona
  • Carbenoxolone USP/EP/BP
  • 3-(3-CARBOXY-1-OXOPROPOXY)-11-OXO-OLEAN-12-EN-29-OIC ACID
  • Carbenoxolon
  • Olean-12-en-29-oic acid, 3-(3-carboxy-1-oxopropoxy)-11-oxo-, (3β,20β)-
  • Carbenoxolone-d4
  • Carbenoxolone (YP 003)
  • glycyrrhetnic acid
  • bioral
  • biogastrone
  • 3-beta-hydroxy-11-oxo-olean-12-en-30-oicacihydrogensuccinate
  • 3-beta-(3-carboxypropionyloxy)-11-oxo-olean-12-en-30-oicacid
  • (3beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic acid
  • CARBENOXOLONE [U
  • 2-Methylidene-2,3-dihydrofuran-3-one
  • CARBENOXOLONE(RG)
  • Olean-12-en-29-oic acid,3-(3-carboxy-1-oxopropoxy)-11-oxo-,(3b,20b)-
  • 3beta-Hydroxy-11-oxoolean-12-en-30-oic acid hydrogen succinate
  • glycyrrhetinic acid hydrogen succinate
  • 3β-[(β-Carboxypropionyl)oxy]-11-oxoolean-12-en-30-oic acid
  • CARBENOXOLONE

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