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Carbenoxolone disodium

Carbenoxolone disodium Structure
Carbenoxolone disodium
  • CAS No.7421-40-1
  • Chemical Name:Carbenoxolone disodium
  • CBNumber:CB3680281
  • Molecular Formula:C34H48Na2O7
  • Formula Weight:614.72
  • MOL File:7421-40-1.mol
Carbenoxolone disodium Property
  • Melting point >275°C (dec.)
  • storage temp. 2-8°C
  • solubility Methanol (Slightly), Water (Slightly)
  • pka pKa1 4.18; pKa2 5.52(at 25℃)
  • form Solid
  • color White to Off-White
  • Water Solubility Soluble in water to 100 mM.
  • Stability Hygroscopic
  • LogP 7.083 (est)
  • CAS DataBase Reference 7421-40-1(CAS DataBase Reference)
  • FDA UNII F1MP7242Z5
  • UNSPSC Code 12352108
  • NACRES NA.22
Safety
  • Hazard Codes  :Xn,Xi
  • Risk Statements  :22-36
  • Safety Statements  :26-36
  • WGK Germany  :3
  • RTECS  :RK0250000
  • Toxicity :LD50 in male mice (mg/kg): 198 i.v.; 120 i.p.; in male rats (mg/kg): 3200 orally (Robson, Sullivan)
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H319
  • Precautionary statements P305+P351+P338
Carbenoxolone disodium Price More Price(2)
  • Brand: Sigma-Aldrich(India)
  • Product number: C4790
  • Product name : Carbenoxolone disodium salt
  • Purity: ≥98%
  • Packaging: 1G
  • Price: ₹4319.18
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: C4790
  • Product name : Carbenoxolone disodium salt
  • Purity: ≥98%
  • Packaging: 5G
  • Price: ₹13433.83
  • Updated: 2022/06/14
  • Buy: Buy

Carbenoxolone disodium Chemical Properties,Usage,Production

  • Chemical Properties White Solid
  • Originator Biogastrone,Winthrop,UK,1963
  • Uses Anti-inflammatory glucocorticoid related to Enoxolone. Antiulcerative
  • Uses beta-adrenergic agonist, growth stimulant
  • Uses Carbenoxolone is anti-inflammatory. It is often used as a gap junction inhibitor in neuroscience research. Carbenoxolone is also an inhibitor of the steroid dehydrogenase enzymes 11 β-hydroxysteroid dehydrogenase (human) and 3α, 20 β-hydroxysteroid dehydrogenase (bacterial). It is used for the treatment of digestive tract ulcers, especially in the stomach. Used in the treatment of peptic, mainly gastric, ulcers. It is often used as a gap junction inhibitor in neuroscience research.
  • Definition ChEBI: Carbenoxolone sodium is a triterpenoid.
  • Manufacturing Process 23.5 g of glycyrrhetinic acid were dissolved in 50 cc of dry pyridine. A solution of 6.0 g of succinic anhydride in 30 cc of dry pyridine was added, followed by 30 cc of dry triethylamine and then, for washing purposes, 5 cc of dry pyridine. The solution was heated on a boiling water bath for ten hours and then poured into excess of dilute hydrochloric acid and ice. The fine gray precipitate formed was filtered off, washed with water, dissolved in chloroform, and the solution repeatedly extracted with dilute hydrochloric acid and later with water. It was dried over sodium sulfate and evaporated to dryness. Crystallization from methanol, using charcoal to effect decolorization, gave the hydrogen succinate as cream-colored crystals, MP 291° to 294°C, with previous softening.
    One molecular proportion of glycyrrhetinic acid hydrogen succinate was ground with a dilute (5%) aqueous solution containing two molecular proportions of sodium hydroxide. The solution was filtered and evaporated in vacuum over concentrated sulfuric acid. The sodium salt is then obtained as a creamy white water-soluble solid. Glycyrrhetinic acid is obtainable from licorice root.
  • Therapeutic Function Antiinflammatory (gastric)
  • General Description Carbenoxolone disodium is a water soluble disodium salt of glycyrrhetinic acid hemisuccinate. It acts as an efficient promoter for the nasal absorption of insulin.
  • Biological Activity Glucocorticoid that inhibits 11 β -hydroxysteroid dehydrogenase (11-HSD) and blocks gap juntion communication.
  • storage Store at +4°C
  • References [1]. jellinck ph, monder c, mcewen bs, et al. differential inhibition of 11 beta-hydroxysteroid dehydrogenase by carbenoxolone in rat brain regions and peripheral tissues. j steroid biochem mol biol, 1993, 46(2): 209-213.
    [2]. sagar gd, larson dm. carbenoxolone inhibits junctional trasnfer and upregulates connexin43 expression by a protein kinase a-dependent pathway. j cell biochem, 2006, 98(6): 1543-1551.
Carbenoxolone disodium Preparation Products And Raw materials
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Carbenoxolone disodium Spectrum
7421-40-1, Carbenoxolone disodiumRelated Search:
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  • C34H48Na2O7
  • 甘珀酸钠,10 MM DMSO 溶液
  • CARBENOXOLONE DISODIUM SALT,PANX1 HEMICHANNEL抑制剂
  • (2S,4AS,6AS,6BR,8AR,10S,12AS,12BR,14BR)-10-((3-羧基丙酰基)氧基)-2,4A,6A,6B,9,9,12A-七甲基-13-氧代-1,2,3,4,4A,5,6,6A,6B,7,8,8A,9,10,11,12,12A,12B,13,14B-二十氢苉-2-羧酸二钠盐
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  • 甘珀酸 二钠盐
  • 甘珀酸钠
  • 7421-40-1
  • Carbenoxolone disodium, 10 mM in DMSO
  • Carbenoxolone disodium salt, Panx1 hemichannel inhibitor
  • Sodium (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-((3-carboxylatopropanoyl)oxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylate
  • (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-((3-carboxypropanoyl)oxy)-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid, sodium salt
  • Carbenoxolonedisodium,(3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oicaciddisodium
  • Carbenoxolone disodi
  • Carbenoxolone disodium USP/EP/BP
  • DISODIUM 3-(3-CARBOXY-1-OXOPROPOXY)-11-OXO-OLEAN-12-EN-29-OIC ACID
  • Carbenoxolone disodium (YP 003 disodium)
  • Carbenoxolone (sodium salt)
  • Disodium (2S,4aS,6aR,6aS,6bR,8aR,10S,12aS,14bR)-2,4a,6a,6b,9,9,12a-heptamethyl-10-(4-oxido-4-oxobutanoyl)oxy-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1H-picene-2-carboxylate
  • Carbenoxolone disodiuM salt >=98%
  • (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oicaciddisodium
  • 3β-(3-Carboxypropionyloxy)-11-oxoolean-12-en-30-oic acid disodium salt
  • 18β-Glycyrrhetinic acid hydrogen succinate disodium salt
  • (20S)-3β-[(3-Carboxypropanoyl)oxy]-11-oxoolean-12-en-29-oic acid disodium salt
  • disodium 4-(20-carboxylato-11-oxo-30-beta-norolean-12-en-3-yloxy)-4-oxobutyrate
  • carbenoxolone disodium
  • Carbenoxalone Sodium
  • 3-Hydroxy-11-oxoolean-12-en-30-oic Acid Hydrogen Succinate Disodium Salt
  • (3,20)-3-(3-Carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic Acid
  • Carbenoxolone sodium [USAN:JAN]
  • 3β-hydroxy-11-oxoolean-12-en-30-oic acid 3-hemisuccinate
  • ulcus-tablinen
  • sodiumcarbenoxolone
  • sodium3-beta-hydroxy-11-oxo-12-oleanen-30-oatesodiumsuccinate
  • sanodin
  • pyrogastrone
  • olean-12-en-30-oicacid,3-beta-hydroxy-11-oxo-,hydrogensuccinate,disodiums
  • olean-12-en-29-oicacid,3-(3-carboxy-1-oxopropoxy)-11-oxo-,disodiumsalt,(

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