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Fatostatin A

Fatostatin A Structure
Fatostatin A
  • CAS No.125256-00-0
  • Chemical Name:Fatostatin A
  • CBNumber:CB92627880
  • Molecular Formula:C18H18N2S
  • Formula Weight:294.41
  • MOL File:125256-00-0.mol
Fatostatin A Property
  • Boiling point 474.3±55.0 °C(Predicted)
  • Density 1.125±0.06 g/cm3(Predicted)
  • storage temp. under inert gas (nitrogen or Argon) at 2-8°C
  • solubility Soluble in DMSO (up to 25 mg/ml).
  • form solid
  • pka 3.46±0.10(Predicted)
  • color Yellow
  • Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H413-H301
  • Precautionary statements P264-P270-P301+P310-P321-P330-P405-P501

Fatostatin A Chemical Properties,Usage,Production

  • Description Fatostatin (125256-00-0) blocks adipogenesis by inhibiting the activation of SREBP. Inhibits the ER-Golgi translocation of SREBPs via binding to their escort protein (SCAP). Fatostatin prevents increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice.1?Inhibits high glucose-induced TGF-β in mesangial cells.2?Cell permeable.
  • Uses Fatostatin A is Cell permeable inhibitor of SREBP activation.
  • Definition ChEBI: 4-(4-methylphenyl)-2-(2-propyl-4-pyridinyl)thiazole is a member of thiazoles.
  • in vivo

    Fatostatin (125B11) (30 mg/kg; 150 μL; i.p. injection; daily for 28 days) reduces adiposity, ameliorated fatty liver by reducing triglyceride (TG) storage, and lowered hyperglycemia in ob/ob mice[2].

    Animal Model:Four-to-five-week-old homozygous male obese (ob/ob) mice (C57BL/6J)[2]
    Dosage:30 mg/kg; 150 μL
    Administration:i.p. injection; daily for 28 days
    Result:Blocked increases in body weight, blood glucose, and hepatic fat accumulation in obese ob/ob mice, even under uncontrolled food intake.
  • References 1) Kamisuki et al. (2009), A small molecule that blocks fat synthesis by inhibiting the activation of SREBP; Chem. Biol., 16 882 2) Uttarwar et al. (2012), SREBP-1 activation by glucose mediates TGF-β upregulation in mesangial cells; Am. J. Physiol. Renal Physiol., 302 F329
Fatostatin A Preparation Products And Raw materials
Raw materials
Preparation Products
Fatostatin A Suppliers
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Fatostatin A Spectrum
125256-00-0, Fatostatin ARelated Search:
  • 化学试剂
  • 抑制剂
  • 药靶配体
  • 化合物FATOSTATIN A,10 MM DMSO 溶液
  • FATOSTATIN FREE BASE
  • 化合物FATOSTATIN A
  • 2-(2-丙基吡啶-4-基)-4-(对甲苯基)噻唑
  • 脂肪抑制素
  • 125256-00-0
  • Fatostatin, 10 mM in DMSO
  • mice,125B11,prostate,cancer,Fatty Acid Synthase (FASN),gene,human,insulin-induced,Fatostatin,ob/ob,inhibit,expression,Golgi,Inhibitor,adipogenesis,SREBP-mediated
  • 2-(2-propylpyridin-4-yl)-4-(p-tolyl)thiazole
  • Pyridine, 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-
  • 125B11
  • 4-(4-methylphenyl)-2-(2-propylpyridin-4-yl)-1,3-thiazole

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