ChemicalBook > CAS DataBase List > XL-647

XL-647

XL-647 Structure
XL-647
  • CAS No.781613-23-8
  • Chemical Name:XL-647
  • CBNumber:CB82628532
  • Molecular Formula:C24H25Cl2FN4O2
  • Formula Weight:491.3853032
  • MOL File:781613-23-8.mol
XL-647 Property
  • Boiling point 567.9±50.0 °C(Predicted)
  • Density 1.356
  • storage temp. Store at -20°C
  • solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml
  • form A solid
  • pka 10.16±0.40(Predicted)
  • color White to off-white
  • FDA UNII F6XM2TN5A1
  • NCI Drug Dictionary tesevatinib
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H314
  • Precautionary statements P260-P280-P303+P361+P353-P301+P330+P331-P304+P340+P310-P305+P351+P338+P310

XL-647 Chemical Properties,Usage,Production

  • Uses XL 647 is a potent and selective EGFR phosphorylation inhibitor and may be used in the treatment of patients suffering from lung cancer. Orally available, multi-target tyrosine kinase inhibitor.
  • Definition ChEBI: Tesevatinib is a member of the class of quinazolines that is quinazoline substituted by (3,4-dichloro-2-fluorophenyl)amino, methoxy, and [(3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl]methoxy groups at positions 4, 6 and 7, respectively. It is a multi-target tyrosine kinase inhibitor of EGFR, ErbB2, KDR, Flt4 and EphB4 and exhibits anti-cancer properties. It has a role as an antineoplastic agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an epidermal growth factor receptor antagonist. It is a member of quinazolines, an aromatic ether, a member of monofluorobenzenes, a dichlorobenzene, a secondary amino compound, a diether and a tertiary amino compound.
  • in vivo

    Tesevatinib (XL-647) shows potent and long-lived inhibition of the WT EGFRin vivo. Tesevatinib (XL-647) substantially inhibits the growth of H1975 xenograft tumors and reduces both tumor EGFR signaling and tumor vessel density[1].

  • IC 50 EGFR: 0.3 nM (IC50); ErbB2: 16 nM (IC50); KDR: 1.5 nM (IC50); Flt-4: 8.7 nM (IC50)
XL-647 Preparation Products And Raw materials
Raw materials
Preparation Products
XL-647 Suppliers
Global(73)Suppliers
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
  • Supplier：
    BOC Sciences
  • Tel：+1-631-485-4226
  • Email：inquiry@bocsci.com
  • Country：United States
  • ProdList：19552
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
  • Supplier：
    Aceschem Inc.
  • Tel：+1-817863-6948<br/>+1-（817）863-6948
  • Email：sales@aceschem.com
  • Country：United States
  • ProdList：19632
  • Advantage：58
  • Supplier：
    Chongqing Chemdad Co., Ltd
  • Tel：+86-023-6139-8061<br/>+86-86-13650506873
  • Email：sales@chemdad.com
  • Country：China
  • ProdList：39894
  • Advantage：58
XL-647 Spectrum
781613-23-8, XL-647Related Search:
  • 抑制剂
  • 标准品
  • 细胞生物学试剂
  • C24H25Cl2FN4O2
  • 多靶点酪氨酸激酶抑制剂(XL-647)
  • 化合物TESEVATINIB,10 MM DMSO 溶液
  • N-(3,4-二氯-2-氟苯基)-6-甲氧基-7-(((3AR,5R,6AS)-2-甲基八氢环戊烷并[C]吡咯-5-基)甲氧基)喹唑啉-4-胺
  • 化合物TESEVATINIB
  • N-(3,4-二氯-2-氟苯基)-6-甲氧基-7-(((3AR,5R,6AS)-2-甲基八氢环戊戊二烯并[C]吡咯-5-基)甲氧基)喹唑啉-4-胺
  • N-(3,4-二氯-2-氟苯基)-6-甲氧基-7-[[(3AALPHA,5BETA,6AALPHA)-八氢-2-甲基环戊并[C]吡咯-5-基]甲氧基]-4-喹唑啉胺
  • 781613-23-8
  • Tesevatinib, 10 mM in DMSO
  • N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
  • 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aα,5β,6aα)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-
  • XL647 /EXEL-7647
  • XL647,Tesevatinib,EXEL 7647,KD019,HER1,Ephrin Receptor,Inhibitor,VEGFR,KD 019,Vascular endothelial growth factor receptor,Epidermal growth factor receptor,EGFR,ErbB-1,XL 647,EXEL7647,inhibit
  • Rel-N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-2-methyloctahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
  • KD-019
  • EXEL-7647;XL-647;XL 647
  • N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-[[(3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta[c]pyrrol-5-yl]methoxy]-4-quinazolinamine
  • N-(3,4-dichloro-2-fluorophenyl)-6-Methoxy-7-(((3aR,6aS)-2-Methyloctahydrocyclopenta[c]pyrrol-5-yl)Methoxy)quinazolin-4-aMine
  • XL-647
  • Tesevatinib(XL647)
  • Tesevatinib

Home

My