ChemicalBook > CAS DataBase List > Fatostatin A

Fatostatin A

Fatostatin A Structure
Fatostatin A
  • CAS No.298197-04-3
  • Chemical Name:Fatostatin A
  • CBNumber:CB12602999
  • Molecular Formula:C18H19BrN2S
  • Formula Weight:375.33
  • MOL File:298197-04-3.mol
Fatostatin A Property
  • storage temp. 2-8°C
  • solubility DMSO: ≥10mg/mL
  • form powder
  • color light yellow to yellow
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • Hazard Codes  :Xn
  • Risk Statements  :22
  • WGK Germany  :1
  • NFPA 704:
    0
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
Fatostatin A Price More Price(3)
  • Brand: Sigma-Aldrich(India)
  • Product number: F8932
  • Product name : Fatostatin hydrobromide
  • Purity: ≥98% (HPLC), powder
  • Packaging: 5MG
  • Price: ₹12329.68
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: F8932
  • Product name : Fatostatin hydrobromide
  • Purity: ≥98% (HPLC), powder
  • Packaging: 25MG
  • Price: ₹65545.38
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: 341329
  • Product name : Fatostatin - CAS 298197-04-3 - Calbiochem
  • Purity: A cell-permeable diarylthiazole compound that prevents the cellular activation of the SREBP-1/2 precursors to the active nuclear forms by blocking SRE
  • Packaging: 25MG
  • Price: ₹15469.99
  • Updated: 2022/06/14
  • Buy: Buy

Fatostatin A Chemical Properties,Usage,Production

  • Uses Fatostatin hydrobromide has been used:
    • to study its anti-cancer activity and effects on mitotic microtubule spindle
    • to study its effects on stomatal development
    • to prevent SREBP cleavage-activating protein (SCAP)-mediated escort of sterol regulatory element-binding proteins (SREBPs)

  • Uses Fatostatin A is an inhibitor of sterol regulatory element binding protein (SREBP). Fatostatin A reverses hyperglycemia in diabetic mice. Cell permeable. Fatostatin A is used for the treatment and/or prevention of one or more metabolic disorders.
  • General Description Fatostatin is a non-sterol diarylthiazole derivative. It prevents insulin-induced adipogenesis and lowers the amounts of fatty acid, triglyceride and low-density lipoprotein. Fatostatin has anti tumor and antimitotic properties.
  • Biological Activity fatostatin a is an inhibitor of sterol regulatory element binding protein (srebp), which can inhibit the activation of srebp-1 and srebp-2[1].fatostatin a (0.1-1 μm; 3 days) inhibits the androgen-independent proliferation of prostate cancer cell in a manner independent of the known igf1 signaling pathway. fatostatin a inhibits insulin-induced fat formation in 3t3-l1 cells[2].fatostatin a (30 mg/kg; 150 ml; i.p.; daily for 28 days) prevents obese ob/ob mice from increasing their weight, blood sugar, and liver fat accumulation, even if they do not control the food intake of mice[1].[1]. kamisuki s, et al. a small molecule that blocks fat synthesis by inhibiting the activation of srebp. chem biol. 2009, 16(8): 882-92.[2]. choi y, et al. identification of bioactive molecules by adipogenesis profiling of organic compounds. j biol chem. 2003, 278(9): 7320-4.
  • Biochem/physiol Actions Fatostatin hydrobromide is an SREBP inhibitor. Fatostatin hydrobromide inhibits fat production and lowers glucose levels in mice by inhibiting SREBP (Sterol Regulatory Element Binding Proteins).
  • storage Store at +4°C
Fatostatin A Preparation Products And Raw materials
Raw materials
Preparation Products
Fatostatin A Suppliers
Global(91)Suppliers
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58
  • Supplier：
    Career Henan Chemica Co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：laboratory@coreychem.com
  • Country：China
  • ProdList：30231
  • Advantage：58
  • Supplier：
    InvivoChem
  • Tel：+1-708-310-1919<br/>+1-13798911105
  • Email：sales@invivochem.cn
  • Country：United States
  • ProdList：6391
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：
  • Email：support@targetmol.com
  • Country：United States
  • ProdList：38630
  • Advantage：58
Fatostatin A Spectrum
298197-04-3, Fatostatin ARelated Search:
  • API
  • Aromatics, Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
  • 抑制剂
  • 药靶配体
  • 细胞生物学试剂
  • C18H18N2SHBr
  • 化合物FATOSTATIN,10 MM DMSO 溶液
  • FATOSTATIN,SREBP (STEROL REGULATORY BINDING蛋白) TRANSCRIPTION FACTORS ACTIVATION.
  • 2-(2-丙基吡啶-4-基)-4-(对甲苯基)噻唑 氢溴酸盐
  • FATOSTATIN氢溴酸盐
  • 氢溴化他汀
  • 盐酸脂肪抑制素
  • SREBP抑制剂(FATOSTATIN A)
  • 4-[4-(4-甲基苯基)-2-噻唑基]-2-丙基吡啶氢溴酸盐
  • 298197-04-3
  • Fatostatin hydrobromide, 10 mM in DMSO
  • Fatostatin, SREBP (Sterol regulatory binding protein) transcription factors activation.
  • Golgi,ob/ob,inhibit,Fatostatin hydrobromide,prostate,SREBP-mediated,cancer,mice,insulin-induced,adipogenesis,Fatty Acid Synthase (FASN),gene,human,expression,Inhibitor,125B11
  • Fatostatin HBr，125B-11
  • Fatostatin - CAS 298197-04-3 - Calbiochem
  • Fatostatin hydrobromide - Fatostatin A hydrobromide | 125B11 hydrobromide
  • CS-2596
  • Fatostatin HBr
  • Fatostatin A HBr
  • Fatostatin
  • Fatostatin hydrobromide
  • 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propylpyridine hydrobromide
  • 25B11 hydrobromide
  • 2-(2-propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide
  • Fatostatin A HydrobroMide
  • 4-[4-(4-Methylphenyl)-2-thiazolyl]-2-propylpyridine MonohydrobroMide
  • Fatostatin A

Home

My