ChemicalBook > CAS DataBase List > N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Structure
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
  • CAS No.902135-91-5
  • Chemical Name:N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl
  • CBNumber:CB52473801
  • Molecular Formula:C16H18Cl3N5O2
  • Formula Weight:418.7
  • MOL File:902135-91-5.mol
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Property
  • storage temp. Store at -20°C
  • solubility ≥29.93 mg/mL in H2O; ≥43.3 mg/mL in DMSO with ultrasonic; ≥8.82 mg/mL in EtOH with ultrasonic
  • form crystalline solid
  • color White to off-white
  • FDA UNII X1BF92PW9T
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H315-H319-H335
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501

N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Chemical Properties,Usage,Production

  • Description AT7519 is an ATP-competitive inhibitor of cyclin-dependent kinases (Cdks) with IC50 values of 210, 47, 100, 13, 170, and <10 nM for Cdk1, 2, 4, 5, 6, and 9, respectively. It is less potent against Cdk3 and Cdk7 and inactive against non-Cdk kinases save for GSK3β (IC50 = 89 nM). AT7519 demonstrates antiproliferative activity against a wide variety of human tumor cell lines (IC50s = 40-940 nM in vitro), inhibiting cell cycle progression and inducing apoptosis, and prevents tumor growth in human tumor xenograft models. AT7519 induces activation of GSK3β by down-regulating GSK3β phosphorylation, which contributes to AT7519-induced apoptosis.
  • Uses 4-(2,6-DichlorobenzoylaMino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylaMide Monohydrochloride is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.
  • Uses 4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide is used in the structure based design of a cyclin-dependant kinase CDK2 inhibitor.
  • in vivo

    AT7519 inhibits tumor growth in a human MM xenograft mouse model[1]. AT7519 (4.6 and 9.1 mg/kg/dose) inhibits the growth of early-stage HCT116 tumor xenografts. AT7519 (10 mg/kg, i.p.) also inhibits the target CDKs in HCT116 tumor-bearing BALB/c nude mice[2].

  • IC 50 CDK9/Cyclin T: 10 nM (IC50); CDK5/p35: 13 nM (IC50); cdk2/cyclin A: 47 nM (IC50); Cdk4/cyclin D1: 100 nM (IC50); cdk6/cyclin D3: 170 nM (IC50); Cdk1/cyclin B: 210 nM (IC50); CDK7/Cyclin H/MAT1: 2400 nM (IC50); GSK3β: 89 nM (IC50)
N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Preparation Products And Raw materials
Raw materials
Preparation Products
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N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl Spectrum
902135-91-5, N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide HclRelated Search:
  • Inhibitors
  • 信号转导通路激酶抑制剂
  • 化学试剂
  • 高纯试剂
  • 药靶配体
  • 抑制剂
  • 小分子抑制剂
  • 小分子抑制剂，天然产物
  • C16H17Cl2N5O2ClH
  • C16H18Cl3N5O2
  • C16H17Cl2N5O2HCl
  • 化合物AT 7519 HYDROCHLORIDE SALT,10 MM DMSO 溶液
  • 化合物 AT 7519 HYDROCHLORIDE SALT
  • 4-(2,6-二氯苯甲酰胺基)-N-(哌啶-4-基)-1H-吡唑-3-甲酰胺盐酸盐
  • AT 7519 盐酸盐
  • N-(4-哌啶基)-4-(2,6-二氯苄氨基)-1H-吡唑-3-羧胺盐酸盐
  • N-(4-哌啶基)-4-(2,6-二氯苯甲酰基氨基)-1H-吡唑-3-甲酰胺盐酸盐
  • N-(4-哌啶基)-4-(2,6-二氯苄氨基)-1H-吡唑-3-羧氨盐酸盐
  • 902135-91-5
  • AT7519 Hydrochloride, 10 mM in DMSO
  • AT-7519 diHCl
  • AT7519; AT-7519
  • CS-266
  • 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide HCl
  • AT7519;AT-7519;AT 7519 HYDROCHLORIDE;AT-7519 HYDROCHLORIDE
  • 4-(2,6-Dichlorobenzamido)-N-(piperidin-4-yl)-1H-pyrazole-3-carboxamide hydrochloride
  • AT 7519 hydrochloride salt
  • AT7519 HCl, >=99%
  • AT-7519(HCI)
  • AT7519 HCl
  • AT 7519 HCl salt
  • AT 7519 N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride
  • 4-(2,6-Dichlorobenzoylamino)-1H-pyrazole-3-carboxylic Acid Piperidin-4-ylamide Monohydrochloride
  • Light yellow solid
  • AT7519 (Hydrochloride)
  • N-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide hydrochloride
  • AT 7519
  • N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide Hcl

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