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Dopamine hydrochloride

CAS No.62-31-7
Chemical Name:Dopamine hydrochloride
CBNumber:CB9243534
Molecular Formula:C8H12ClNO2
Formula Weight:189.64
MOL File:62-31-7.mol

Dopamine hydrochloride Property

Melting point 248-250 °C(lit.)
Density 1.4 g/cm3
Flash point 11℃
storage temp. Store below +30°C.
solubility alcohol: 20 mg/mL
form Crystalline Powder
color light tan
Water Solubility soluble
Sensitive Air & Light Sensitive
Merck 14,8462
BRN 3656720
Stability Stable. Incompatible with strong oxidizing agents. Combustible.
InChIKey CTENFNNZBMHDDG-UHFFFAOYSA-N
CAS DataBase Reference 62-31-7(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 7L3E358N9L
EPA Substance Registry System 1,2-Benzenediol, 4-(2-aminoethyl)-, hydrochloride (62-31-7)
UNSPSC Code 41116107
NACRES NA.77

Safety

Hazard Codes :Xi,N,Xn,T,F
Risk Statements :36/37/38-50/53-22-39/23/24/25-23/24/25-11
Safety Statements :26-36-61-45-36/37-16
RIDADR :UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany :2
RTECS :UX1092000
F :8-10-23
Hazard Note :Irritant
TSCA :Yes
HS Code :29222900
Toxicity :LD50 orally in Rabbit: 2859 mg/kg

NFPA 704:

	1
0		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H302
Precautionary statements P301+P312+P330

Dopamine hydrochloride Price More Price(13)

Brand: Sigma-Aldrich(India)
Product number: H8502
Product name : Dopamine hydrochloride
Purity:
Packaging: 5G
Price: ₹2392.33
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: H8502
Product name : Dopamine hydrochloride
Purity:
Packaging: 10G
Price: ₹4394.95
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Brand: Sigma-Aldrich(India)
Product number: H8502
Product name : Dopamine hydrochloride
Purity:
Packaging: 25G
Price: ₹8064.63
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Brand: Sigma-Aldrich(India)
Product number: PHR1090
Product name : Dopamine hydrochloride
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1G
Price: ₹8465.15
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: H8502
Product name : Dopamine hydrochloride
Purity:
Packaging: 100G
Price: ₹47132.05
Updated: 2022/06/14
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Dopamine hydrochloride Chemical Properties,Usage,Production

Description Dopamine (hydrochloride) is an endogenous catecholamine neurotransmitter synthesized from the amino acid L-tyrosine that acts as an agonist at dopamine receptors (D_1-5). Dopamine is mainly synthesized in the substantia nigra and ventral tegmental area, and is a precursor in norepinephrine and epinephrine biosynthesis. Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release. Dopamine is also synthesized in the adrenal glands where it exerts peripheral paracrine functions including control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes. Loss or damage of dopaminergic neurons in the substantia nigra is associated with Parkinson’s disease.
Chemical Properties Dopamine hydrochloride is designated chemically as 3,4-dihydroxyphenethylamine hydrochloride, a white crystalline powder freely soluble in water. It can also be dissolved in hot 95% ethanol, methanol, and sodium hydroxide solution. However, it is insoluble in chloroform, ether, and benzene. It has no odor and a slightly bitter taste. Dopamine (also referred to as 3-hydroxytyramine) is a naturally occurring biochemical catecholamine precursor of norepinephrine.
Uses Endogenous catecholamine with α and β-adrenergic activity. Cardiotonic; antihypotensive.
Uses A neurotransmitter and vasopressor that modulates cortical activation. Dopamine hydrochloride is a vasopressor that moderates cortical activation. It is used as a precursor to norepinepherine and epinephrine. It is an important neurotransmitter and chemical messenger that helps in the transmission of signals in the brain and other vital areas.
Uses dopaminergic: Dopamine (DA) works as neurotransmitter in the central nervous system. It is a catecholamine made from the amino acid L-tyrosine. It also works as a hormone in vesicles of the adrenal medulla, thereby controlling heart beat rate and blood pressure. Absence of DA-containing neurons is associated with parkinson′s disease.
Indications Dopamine HCl is indicated for the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure.
Application Dopamine hydrochloride has been used to study dopamine-mediated transient modulation of the physiological responses in whiteleg shrimp, Litopenaeus vannamei.
It has been used to study dopamine-mediated changes in immunity susceptibility to Lactococcus garvieae in the freshwater giant prawn, Macrobrachium rosenbergii.
It has been used to study the molecular link between dopamine-induced oxidative stress and mHtt (mutant Huntingtin) toxicity in relation to the activation of the autophagy pathway in an 'in vitro' model of parkinsonian Huntington's Disease.
Preparation Dopamine hydrochloride is produced through the ring-opening reaction of piperonyl ethylamine. Piperethylamine and phenol are added to a reaction vessel and cooled down. Hydrochloric acid is slowly added while heating up the mixture to 110°C, and refluxed for 12-44 hours until the reaction reaches completion. The solution is then slightly cooled and water is added, and the mixture is stirred well and allowed to separate into layers. The upper phenolic layer is then removed, and the aqueous layer is extracted with isopropyl acetate. The extracted aqueous layer is then evaporated under reduced pressure (8.0kPa) until dry. Half the amount of ethanol and hydrochloric acid are added to the dry residue and heated to dissolve. The solution is then cooled, crystallized, and filtered. The filter cake is washed with ethanol and dried to obtain the final product, with a yield of 74%.
Definition ChEBI: Dopamine hydrochloride is a catecholamine.
brand name Intropin (Mayne).
General Description Dopamine Hydrochloride is the hydrochloride salt form of dopamine, a monoamine compound with positive inotropic activity. Dopamine is a neurotransmitter which is a naturally occurring catecholamine. Dopamine hydrochloride salt is indicated as a medicine for the treatment of acute congestive and renal failures.
Biological Activity Endogenous neurotransmitter that acts as an agonist at dopamine D 1-5 receptors. Synthesized in the substantia nigra and ventral tegmental area, and is a precursor in noradrenalin and adrenalin biosynthesis.
Pharmacokinetics Dopamine hydrochloride(62-31-7) is a precursor for the synthesis of epinephrine in the body. It has β (mainly β1 receptor) receptor agonism and α receptor agonism, and can also promote the release of norepinephrine. It can enhance myocardial contractility, increase cardiac output, and accelerate the heart rate to a lesser extent (not as obvious as isoproterenol); stimulate the α-receptors of blood vessels in tissues such as skin and muscles, so that blood vessels constrict and blood supply is reduced; it stimulates visceral blood vessels ( The dopamine receptors in the kidney, mesentery, and heart) dilate and increase blood flow. The change of total peripheral resistance is not obvious, but it is beneficial to improve the blood supply of vital organs during shock.
Clinical Use Cardiogenic shock in infarction or cardiac surgery
target Dopamine Receptor
Drug interactions Potentially hazardous interactions with other drugs
Alpha-blockers: avoid with tolazoline.
Anaesthetics: risk of ventricular arrhythmias with isoflurane - avoid.
Antidepressants: risk of hypertensive crisis with MAOIs and moclobemide.
Ciclosporin: may reduce risk of ciclosporin nephrotoxicity
Dopaminergics: effects possibly enhanced by entacapone; avoid with rasagiline; risk of hypertensive crisis with selegiline.
Metabolism Dopamine is a metabolic precursor of noradrenaline and, whereas a proportion is excreted as the metabolic products of noradrenaline, the majority is mainly metabolised into 3,4,-dihydroxyphenylacetic acid (DOPAC) and 3-methoxy-4-hydroxyphenylacetic (HVA) which are rapidly excreted in the urine.
storage Store at -20°C