ChemicalBook > CAS DataBase List > Tyramine hydrochloride

Tyramine hydrochloride

CAS No.60-19-5
Chemical Name:Tyramine hydrochloride
CBNumber:CB7345058
Molecular Formula:C8H12ClNO
Formula Weight:173.64
MOL File:60-19-5.mol

Tyramine hydrochloride Property

Melting point 253-255 °C(lit.)
Boiling point 269°C/760mmHg
storage temp. Store below +30°C.
solubility H2O: soluble50 mg/ml, clear, colorless to faintly yellow
form Crystalline Powder
color White to almost white
PH <7 (H2O)
Water Solubility H2O: soluble 50 mg/ml, clear, colorless to faintly yellow
Sensitive Hygroscopic
Merck 14,9835
BRN 3627058
Stability Hygroscopic
LogP 0.722 (est)
CAS DataBase Reference 60-19-5(CAS DataBase Reference)
FDA UNII Z5KDH3H147
EPA Substance Registry System Phenol, 4-(2-aminoethyl)-, hydrochloride (60-19-5)
UNSPSC Code 12352200
NACRES NA.77

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :22-24/25-36-26
WGK Germany :3
RTECS :NL4375000
F :3-8-10
TSCA :Yes
HS Code :29222900

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H335-H315-H319
Precautionary statements P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313

Tyramine hydrochloride Price More Price(15)

Brand: Sigma-Aldrich(India)
Product number: T2879
Product name : Tyramine hydrochloride
Purity: ≥98%
Packaging: 10MG
Price: ₹3009.35
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T2879
Product name : Tyramine hydrochloride
Purity: ≥98%
Packaging: 5G
Price: ₹4957.85
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T2879
Product name : Tyramine hydrochloride
Purity: ≥98%
Packaging: 1G
Price: ₹6040.35
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T2879
Product name : Tyramine hydrochloride
Purity: ≥98%
Packaging: 25G
Price: ₹7057.9
Updated: 2022/06/14
Buy: Buy

Brand: Sigma-Aldrich(India)
Product number: T2879
Product name : Tyramine hydrochloride
Purity: ≥98%
Packaging: 100G
Price: ₹25243.9
Updated: 2022/06/14
Buy: Buy

Tyramine hydrochloride Chemical Properties,Usage,Production

Chemical Properties Off-White to Light Yellow Powder
Occurrence Tyramine was originally a compound isolated from ergot alkaloids and decaying animal tissue. It has pharmacological effects such as increasing blood pressure and exciting the uterus.
Uses Tyramine hydrochloride occurs naturally in the body, and it's found in certain foods. It is an amino acid that helps regulate blood pressure. Tyramine hydrochloride is a sympathomimetic, the hydrochloride salt of the naturally-occurring monoamine derived from the amino acid tyrosine. Tyramine acts as a catecholamine releasing agent but cannot cross the blood-brain barrier.
Application Tyramine hydrochloride (T-HCl) is a kind of fluorogenic substrate of peroxidase. It is a naturally occurring monoamine derived from tyrosine. Tyramine Hydrochloride has been used:
coinfused with adenosine in control subjects and patients in order to reduce leg blood flow by 50% without affecting arterial blood pressure.
labelled with fluorescence dyes (Atto 488 and Atto 655) to serve as a substrate for peroxidase in immunofluorescence analysis.
used in dimethylformamide, labelled with 5-(and-6)carboxyfluorescein, succinimidyl ester/biotin to serve as a substrate for peroxidase in tyramide signal amplification.
Neurotransmitter.
Hazard Tyramine hydrochloride can cause eye irritation and damage in some persons.It also can cause inflammation of the skin oncontact in some persons.Long-term exposure to respiratory irritants may result in disease of the airways involving difficult breathing and related systemic problems.Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis.
Biochem/physiol Actions Tyramine hydrochloride is a biogenic amine and a neuromodulator localized to the nervous system. Tyrosine decarboxylase catalysis the formation of tyramine from tyrosine. Tyramine is found to be associated with a number of psychiatric disorders. Tyramine ingestion depletes serotonin, epinephrine and norepinephrine reserves. This results in elevated biological events such as cardiovascular function, blood pressure, glucose production and overall metabolism. It also causes depression, migraine and insomnia. Tyramine is present is several food sources. The process of food fermentation and spoilage increases its tyramine content.
Synthesis Tyramine [2-(p-hydroxyphenyl) ethylamine], a significant metabolite of tyrosine, enzymatic synthesis of tyramine was established by two-step biocatalytic reaction. Firstly, l-tyrosine was prepared from raw pyruvate fermentation broth under the catalysis of TPL. Pyruvate fermentation broth was simply centrifuged, and then the supernatant was diluted and used as substrate to produce l-tyrosine. Secondly, l-tyrosine was collected as starting material to synthesize tyramine by immobilized TDC cells from Lactobacillus brevis. Pyridoxal phosphate was the common coenzyme for these two enzymes.
Purification Methods Crystallise the hydrochloride from EtOH by addition of diethyl ether, or from conc HCl. [Beilstein 3 II 355.]