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Dobutamine hydrochloride

Dobutamine hydrochloride Structure
Dobutamine hydrochloride
  • CAS No.49745-95-1
  • Chemical Name:Dobutamine hydrochloride
  • CBNumber:CB8274063
  • Molecular Formula:C18H24ClNO3
  • Formula Weight:337.84
  • MOL File:49745-95-1.mol
Dobutamine hydrochloride Property
  • Melting point 184-186 C
  • storage temp. 2-8°C
  • solubility Sparingly soluble in water, soluble in methanol, sparingly soluble in ethanol (96 per cent).
  • form Solid
  • pka 9.45(at 25℃)
  • color White to Off-White
  • Water Solubility Soluble in water or ethanol with warming. Also soluble in methanol
  • λmax 281nm(MeOH)(lit.)
  • Merck 14,3395
  • Stability Solutions are rapidly oxidized at pH 11-13. It is recommended that solutions be freshly prepared and protected from light. Dobutamine hydrochloride is sensitive to light.
  • InChI InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
  • InChIKey BQKADKWNRWCIJL-UHFFFAOYSA-N
  • SMILES C1(O)=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O.[H]Cl
  • CAS DataBase Reference 49745-95-1(CAS DataBase Reference)
  • FDA UNII 0WR771DJXV
  • EPA Substance Registry System 1,2-Benzenediol, 4-[2-[[3-(4-hydroxyphenyl)-1-methylpropyl]amino]ethyl]-, hydrochloride (49745-95-1)
  • UNSPSC Code 41116107
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302+H312+H332-H361
  • Precautionary statements P201-P280-P301+P312+P330-P302+P352+P312-P304+P340+P312-P308+P313
Dobutamine hydrochloride Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: D0676
  • Product name : Dobutamine hydrochloride
  • Purity: ≥98%
  • Packaging: 10MG
  • Price: ₹9006.4
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: D0676
  • Product name : Dobutamine hydrochloride
  • Purity: ≥98%
  • Packaging: 50MG
  • Price: ₹27094.98
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4335
  • Product name : Dobutamine Hydrochloride
  • Purity: 
  • Packaging: 20MG
  • Price: ₹3400
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: D4335
  • Product name : Dobutamine Hydrochloride
  • Purity: 
  • Packaging: 100MG
  • Price: ₹10800
  • Updated: 2022/05/26
  • Buy: Buy

Dobutamine hydrochloride Chemical Properties,Usage,Production

  • Description Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.
  • Chemical Properties Dobutamine hydrochloride occurs as a white to off-white crystalline powder, which is sparingly soluble in water and in alcohol. Dobutamine has a pKa of 9.4.
  • Uses Dobutamine hydrochloride is a catecholamine that acts as a β-adrenergic receptor agonist with potent positive inotropic effects in vivo. It has its strongest effects on β1 receptors, with lesser but significant β2 receptor activation and only weak α1 receptor actions. As a result, it strongly increases cardiac contractility with modest chronotropic, arrhythmogenic, and vascular side effects. It is also a polyphenolic antioxidant and can inhibit all human carbonic anhydrase isoforms with Ki values near 1 ?M.
  • Uses Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.
  • Definition ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m nagement of acute heart failure.
  • brand name Dobutrex (Lilly）.
  • Biological Activity β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.
  • Biochem/physiol Actions Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.
  • Pharmacokinetics Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.
  • Veterinary Drugs and Treatments Dobutamine is used as a rapid-acting injectable positive inotropic agent for short-term treatment of heart failure. It is also useful in shock patients when fluid therapy alone has not restored acceptable arterial blood pressure, cardiac output, or tissue perfusion.
  • storage Desiccate at RT
Dobutamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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Dobutamine hydrochloride Spectrum
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