49745-95-1

Dobutamine hydrochloride, a dopamine derivative, is a selective β1-adrenergic agonist. It is a sympathomimetic agent with inotropic action (changes strength of muscle contraction) on the heart. However, it may have some α and β2-agonist properties as well.The active substance strengthens the contraction power of the heart, increases the stroke volume and thus the blood circulation of the organs. It is used for the treatment of acute heart failure and for cardiac stress tests.

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Dobutamine Hydrochloride is a sympathomimetic drug used to treat heart failure by inhibiting β1 receptors in the sympathetic nervous system. Cardiotonic.

ChEBI: The hydrochloride salt of dobutamine. A beta1-adrenergic receptor agonist that has cardiac stimulant action without evoking vasoconstriction or tachycardia, it is used to increase the contractility of the heart in the m nagement of acute heart failure.

Dobutrex (Lilly）.

β 1 - and β 2 -adrenoceptor agonist with some action at the α 1 -adrenoceptor.

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not cause the release of endogenous norepinephrine, as does dopamine. In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol.

Dobutamine is used as a rapid-acting injectable positive inotropic agent for short-term treatment of heart failure. It is also useful in shock patients when fluid therapy alone has not restored acceptable arterial blood pressure, cardiac output, or tissue perfusion.

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