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1-Aminobenzotriazole

CAS No.1614-12-6
Chemical Name:1-Aminobenzotriazole
CBNumber:CB9185384
Molecular Formula:C6H6N4
Formula Weight:134.14
MOL File:1614-12-6.mol

1-Aminobenzotriazole Property

Melting point 81-84 °C (lit.)
Boiling point 237.24°C (rough estimate)
Density 1.2769 (rough estimate)
refractive index 1.7000 (estimate)
RTECS DM1235000
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Soluble in DMSO (up to 30mg/ml)
form Crystalline Powder
pka 2.09±0.30(Predicted)
color Yellow to beige or light brown
Water Solubility slightly soluble
BRN 607843
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
CAS DataBase Reference 1614-12-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 9EFF75BJ1O
UNSPSC Code 12352200
NACRES NA.77

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36-37/39
WGK Germany :3
Hazard Note :Irritant
HS Code :29349990

NFPA 704:

	0
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordWarning
Hazard statements H315-H319-H335
Precautionary statements P261-P264-P271-P280-P302+P352-P305+P351+P338

1-Aminobenzotriazole Price More Price(2)

Brand: TCI Chemicals (India)
Product number: A1464
Product name : 1-Aminobenzotriazole
Purity: min. 98.0 %
Packaging: 1G
Price: ₹10200
Updated: 2022/05/26
Buy: Buy

Brand: TCI Chemicals (India)
Product number: A1464
Product name : 1-Aminobenzotriazole
Purity: min. 98.0 %
Packaging: 5G
Price: ₹34700
Updated: 2022/05/26
Buy: Buy

1-Aminobenzotriazole Chemical Properties,Usage,Production

Description 1-Aminobenztriazole (1614-12-6) is a pan-specific cytochrome P450 inhibitor acting as a suicide substrate.1,2?Blocks omega-oxidation of arachidonic acid but not its epoxidation.3
Chemical Properties yellow to beige or light brown crystalline powder
Uses 1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H₂O₂-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.
Uses 1-Aminobenzotriazole is used as a Suicide inhibitor of cytochrome P450 and chloroperoxidase, an inhibitor of oxidative drug metabolism in biochemical pharmacology and toxicology studies.
Biochem/physiol Actions 1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.
in vivo
Oral 1-Aminobenzotriazole (ABT) (100 mg/kg, 2 h predose) decreases the clearance of intravenous procainamide (45%) in rats, accompanied by a decreased N-acetylprocainamide-to-procainamide ratio in urine (0.74 versus 0.21) and plasma (area under the curve ratio 0.59 versus 0.11). The urinary recovery of procainamide increases from 18 to 30%, whereas the recovery of N-acetylprocainamide in urine decreases from 13.3 to 6.5% with 1-Aminobenzotriazole^[2]. Pretreatment of rats with 100 mg/kg oral 1-Aminobenzotriazole (ABT) administered 2 hours before a semisolid caloric test meal markedly delays gastric emptying. 1-Aminobenzotriazole also increases stomach weights by 2-fold^[3].
IC 50 CYP2; CYP3
References 1) Mugford?et al.?(1995),?1-Aminobenzotriazole-Induced Destruction of Hepatic and Renal Cytochrome P450 in Male Sprague-Dawley Rats; Fundam. Appl. Tox.,?19?43 2) Emoto?et al.?(2005),?In Vitro Inhibitory Effect of 1-Aminobenzotriazole on Drug Oxidations in Human Liver Microsomes: A Comparison With SKF-525A; Drug Metab. Pharmacokinet.,?20?351 3) Su?et al.?(1998),?Inhibition of Renal Arachidonic Acid Omega-Hydroxylase Activity With ABT Reduces Blood Pressure in the SHR; Am. J. Physiol.,?275?R426