Synthesize
Sulfanilic acid can be used for the determination of nitrite.
Biochemical Research. Organic Synthesis. Sulfanilic acid is an important
intermediate of sulfonamide drugs. This product has strong
antibacterial effect on hemolytic streptococcus, meningitis and coccus,
but due to poor efficacy and high toxicity, it is rarely used for oral
administration. It is also rarely used. It is used as an intermediate
for the synthesis of other sulfonamides, and is also used as a raw
material for the synthesis of agricultural "Huangcaoling" abroad.
Sulfanilic acid can also be used as an analytical reagent, such as a
reagent for the photometric determination of nitrite and sodium
nitroferricyanide. For biochemical research, organic synthesis and
pharmaceutical industry. Sulfanilic acid is the main raw material for
synthesizing sulfonamides. In addition to preparing crystalline
sulfonamides for external anti-inflammatory, it can also synthesize
other sulfonamides such as sulfamidine, sulfamethoxazine, and
sulfamethazine.
Description
Sulfanilic acid (4-amino benzene sulfonic acid ) is an off-white crystalline solid which finds application in quantitative analysis of nitrate and nitrite ions. The solid acid exists as a zwitterion, and has an unusually high melting point.
Chemical Properties
greyish-white crystals or powder
Uses
Sulfanilic acid may be used for the functionalization of single-walled carbon nanotubes (SWNTs) with aryl sulfonate groups.
Uses
Sulfanilic Acid (Sulfadimethoxine EP Impurity D) is a toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.
Uses
A toxic metabolite of Tartrazine (T007700). Used as Ehrlich’s reagent, for detecting of nitrites. Antibacterial.
Definition
ChEBI: An aminobenzenesulfonic acid that is aniline sulfonated at the para-position.
Application
As the compound readily form diazo compounds, it is used to make dyes and sulpha drugs . This property is also used for the quantitative analysis of nitrate and nitrite ions by diazonium coupling reaction with N-(1-Naphthyl) ethylene diamine , resulting in an azo dye, and the concentration of nitrate or nitrite ions were deduced from the color intensity of the resulting red solution by colorimetry.
It is also used as a standard in combustion analysis.
General Description
White powder with faint purple tinge. Grayish-white flat crystals. Becomes anhydrous at around 212°F. Low toxicity (used medicinally).
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Sulfanilic acid is an amino acid. Reacts weakly with both acids and bases.
Fire Hazard
Flash point data for Sulfanilic acid are not available, however Sulfanilic acid is probably combustible.
Synthesis
Sulfanilic acid can be produced by sulfonation of aniline.
Purification Methods
Crystallise the acid (as dihydrate) from boiling water. Dry it at 105o for 2-3hours, then over 90% H2SO4 in a vacuum desiccator. The S-benzylisothiuronium salt has m 187o (from aqueous EtOH). [Beilstein 14 IV 2655.]
