Description
This noraporphiae alkaloid has been obtained from Litsea japonica and Neolitsea
sericea and swells at 11 5-8°C before melting. It is dextrorotatory with [o:lbl +
102.5° (EtOH) and yields a picrate as yellow needles, m.p. 212°C (dec.) and a
picrolonate, m.p. 239°C (dec.). The N-methyl derivative is identical with boldine.
Definition
ChEBI: An isoquinoline alkaloid that is noraporphine substituted by hydroxy groups at positions 2 and 9 and methoxy groups at positions 1 and 10. Isolated from Litsea glutinosa and Lindera chunii, exhibits inhibitory activity against HIV
1 integrase.
References
Nakasato, Nomura., Chem. Pharm. Bull., (Tokyo), 7, 780 (1959)
Kozuka., J. Ph arm. Soc., Japan, 82, 1567 (1962)
See also:
Johns, Lamberton., Austral. J. Chem., 20, 1277 (1967)
