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FALECALCITRIOL

FALECALCITRIOL Structure
FALECALCITRIOL
  • CAS No.83805-11-2
  • Chemical Name:FALECALCITRIOL
  • CBNumber:CB8849801
  • Molecular Formula:C27H38F6O3
  • Formula Weight:524.58
  • MOL File:83805-11-2.mol
FALECALCITRIOL Property
  • Boiling point 576.9±50.0 °C(Predicted)
  • Density 1.24±0.1 g/cm3(Predicted)
  • storage temp. Store at -20°C,unstable in solution, ready to use.
  • solubility Soluble in DMSO
  • form Powder
  • pka 9.77±0.29(Predicted)
  • color White to off-white
  • FDA UNII G70A8514T8
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements

FALECALCITRIOL Chemical Properties,Usage,Production

  • Description Falecalcitriol, previously known as flocalcitrol, was launched by several codevelopers in Japan for the treatment of secondary hyperthyroidism (SHPT). This hexafluorinated analog of 1α,25-dihydroxyvitamin D3 (calcitriol), the hormonally active form of vitamin D3, can be obtained by several different synthetic routes from a conveniently protected cholestenol, a key step being an aldol reaction with hexafluoroacetone. Falecalcitriol is several times more active than 1,25(OH)2D3 in regulating the proliferation of parathyroid cells and parathyroid hormone (PTH) synthesis that are believed to be mediated through binding to VDR, a nuclear receptor for vitamin D; furthermore, it was proposed that a bioactive 23S-hydroxylated metabolite, resistant to further metabolism, contributes to the retention of an active compound for longer in cells and so, to significantly lengthen the duration of action. In a comparative clinical study conducted in hemodialysis patients with moderate to severe SHPT, falecalcitriol was found to be more active than alfacalcidol in suppressing parathyroid hormone without triggering hypercalcemia.
  • Originator University of Wisconsin (US)
  • Uses Hexafluorinated analog of Calcitriol (C144500). A more potent therapeutic agent for secondary hyperparathyroidism.
  • brand name Hornel, Fulstan
  • Hazard A poison by ingestion.
FALECALCITRIOL Preparation Products And Raw materials
Raw materials
Preparation Products
FALECALCITRIOL Suppliers
Global(105)Suppliers
  • Supplier：
    Capot Chemical Co.,Ltd.
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  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
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    CR Corporation Limited
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  • Supplier：
    ChemExpress
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FALECALCITRIOL Spectrum
83805-11-2, FALECALCITRIOLRelated Search:
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Chiral Reagents
  • 抑制剂
  • 化学试剂
  • 原料药
  • C27H38F6O3
  • 氟骨三醇/氟骨化醇
  • (1R,3S,Z)-5-(2-((1R,3AS,7AR,E)-7A-甲基-1-((R)-7,7,7-三氟-6-羟基-6-(三氟甲基)庚-2-基)八氢-4H-茚-4-亚基)亚乙基)-4-亚甲基环己烷-1,3-二醇
  • 氟硅酸三醇
  • 氟骨化醇/FALECALCITRIOL
  • 化合物 T15269
  • 氟骨化醇
  • 氟骨三醇
  • 83805-11-2
  • Fluorotriol
  • Fluorocalcitriol
  • (1R,3S,Z)-5-(2-((1R,3aS,7aR,E)-7a-Methyl-1-((R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl)octahydro-4H-inden-4-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol
  • Hornel
  • Falecalcitol
  • 1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,4S,5Z)-
  • Flocacitriol
  • F6-1α,25-DihydroxyvitaMin D3
  • (1α,3β,5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol
  • (1R,4S,5Z)-4-Methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-Methyl-5-(trifluoroMethyl)hexyl]octahydro-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
  • (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-Methyl-1-[(2R)-7,7,7-trifluoro-6-hydroxy-6-(trifluoromethyl)heptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
  • FALECALCITRIOL
  • 26,27-Hexafluoro-1α,25-dihydroxyvitamine D3
  • 26,26,26,27,27,27-Hexafluoro-1α,25-dihydroxycholecalciferol
  • F6-1,25(OH)2D3
  • 26,27-F6-1,25-(OH)2D3
  • ST 630
  • Ro 23-4194
  • Fulstan
  • Flocalcitrol
  • Flocalcitriol
  • 9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)-
  • 26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3
  • (+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol

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