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DMT-2′Fluoro-dU Phosphoramidite

DMT-2′Fluoro-dU Phosphoramidite Structure
DMT-2′Fluoro-dU Phosphoramidite
  • CAS No.146954-75-8
  • Chemical Name:DMT-2′Fluoro-dU Phosphoramidite
  • CBNumber:CB8500324
  • Molecular Formula:C39H46FN4O8P
  • Formula Weight:748.78
  • MOL File:146954-75-8.mol
DMT-2′Fluoro-dU Phosphoramidite Property
  • storage temp. Sealed in dry,Store in freezer, under -20°C
  • form powder
  • pka 9.39±0.10(Predicted)
  • color white to off-white
  • biological source non-animal source (no BSE/TSE risk)
  • InChIKey HQHQPAYRJJMYQX-YOKGOYKLNA-N
  • SMILES N1(C=CC(=O)NC1=O)[C@@H]1O[C@H](COC(C2=CC=CC=C2)(C2C=CC(=CC=2)OC)C2=CC=C(C=C2)OC)[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)[C@H]1F |&1:8,10,36,51,r|
  • UNSPSC Code 41116105
  • NACRES NA.51
Safety
  • WGK Germany  :3
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal word
  • Hazard statements
  • Precautionary statements
DMT-2′Fluoro-dU Phosphoramidite Price More Price(9)
  • Brand: Sigma-Aldrich(India)
  • Product number: U211280
  • Product name : DMT-2′Fluoro-dU Phosphoramidite
  • Purity: configured for PerkinElmer, configured for Polygen
  • Packaging: 0.25G
  • Price: ₹6083.65
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: U211280
  • Product name : DMT-2′Fluoro-dU Phosphoramidite
  • Purity: configured for PerkinElmer, configured for Polygen
  • Packaging: 1G
  • Price: ₹17006.08
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: U211280
  • Product name : DMT-2′Fluoro-dU Phosphoramidite
  • Purity: configured for PerkinElmer, configured for Polygen
  • Packaging: 2G
  • Price: ₹35603.43
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: U211250
  • Product name : DMT-2′Fluoro-dU Phosphoramidite
  • Purity: configured for (?KTA? and OligoPilot?)
  • Packaging: 1G
  • Price: ₹17006.08
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: U211250
  • Product name : DMT-2′Fluoro-dU Phosphoramidite
  • Purity: configured for (?KTA? and OligoPilot?)
  • Packaging: 5G
  • Price: ₹94264.1
  • Updated: 2022/06/14
  • Buy: Buy

DMT-2′Fluoro-dU Phosphoramidite Chemical Properties,Usage,Production

  • Uses 5'-O-DMT-2'-F-Deoxyuridine-CE Phosphoramidite (DMT-2′Fluoro-dU Phosphoramidite) is a uridine phosphoramidite consisting of a fluorine in the 2' position, and the compound is used in the synthesis of DNA.
  • Definition DMT-2′Fluoro-dU Phosphoramidite is also known as 2'-F-U CE-Phosphoramidite. 2'-F-RNA oligonucleotides adopt an A-form helix on hybridisation to a target. Whereas a hydroxyl group of RNA is a hydrogen bond donor, fluorine appears to be a weak acceptor. These features of 2'-F-RNA oligonucleotides lead to certain interesting properties. For example, it was demonstrated that oligonucleotides hybridise to a RNA oligonucleotide in the following order of increasing stability: DNA < RNA < 2'-OMe-RNA < 2'-F-RNA
  • Synthesis 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluorouridine (3.00 g, 5.47 mmol) was dissolved in anhydrous dichloromethane (50 ml) under an argon atmosphere, N,N-diisopropylethylamine (0.55 ml,3.18 mmol), 1H-tetrazole (0.45 g, 6.45 mmol) and 2-cyanoethyl-N,N,N',N'-tetraisopropylphosphordiamidite (1.92 g, 6.36mmol) were added. And the mixture was stirred at room temperature overnight. The completion of the reaction was confirmed, 5 percent aqueous sodium hydrogen carbonate solution (20 ml) was added to the reaction mixture to allow layer separation, and the organic layer was washed with saturated brine (20 ml). The organic layer was dried over sodium sulfate, the filtrate was concentrated and the obtained crude product was purified by silica gel chromatography (hexane:ethyl acetate=75:25 - 30/70(v/v), containing 3percent triethylamine). The object fractions were collected and concentratedto give DMT-2′Fluoro-dU Phosphoramidite (2.76 g, 67.3 percent).
DMT-2′Fluoro-dU Phosphoramidite Preparation Products And Raw materials
Raw materials
Preparation Products
DMT-2′Fluoro-dU Phosphoramidite Suppliers
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DMT-2′Fluoro-dU Phosphoramidite Spectrum
146954-75-8, DMT-2′Fluoro-dU PhosphoramiditeRelated Search:
  • Amidite
  • 化工中间体
  • 医用原料
  • 抑制剂
  • 亚磷酰胺单体-2'-F Phosphoramidites
  • 核苷单体及高端辅料
  • 有机原料-氨基化合物
  • 核苷原料
  • 小核酸药物相关原料
  • 亚磷酰胺单体
  • 高端化学品
  • 有机化合物
  • 有机化工
  • 核苷
  • 化学试剂
  • 2'-F-DU亚磷酰胺单体/146954-75-8
  • 化合物DMT-2′FLUORO-DU PHOSPHORAMIDITE,10 MM DMSO 溶液
  • DMT-2'-F-DU-CE 亚磷酰胺单体
  • 尿苷杂质50
  • 5'-O-(4, 4'-DIMETHOXYTRITYL)-2'-FLUORO-2'-DEOXYURIDINE-3'-CE-PHOSPHORAMIDITE
  • 5'-O-DMT-2'-氟-脱氧尿苷-3'-氰乙氧基亚磷酰胺
  • 2'-F-DU PHOSPHORAMIDITE
  • (2R,3R,4R,5R)-2-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-5-(2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)-4-氟四氢呋喃-3-基 (2-氰基乙基)二异丙基亚磷酰胺
  • 化合物DMT-2′FLUORO-DU PHOSPHORAMIDITE
  • 5'-O-DMT-2'-FLUORO-DU-CE
  • 2'-F-U亚磷酰胺单体
  • 2'-F亚磷酰胺单体2'-F-DU
  • 没有CAS也要画出来结构--就是兆维网站上的UF一个系列的 一查就知道,产品编号应该是PD5-001
  • (2R,3R,4R,5R)-2-((BIS(4-METHOXYPHENYL)(PHENYL)METHOXY)METHYL)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-FLUOROTETRAHYDROFURAN-3-YL (2-CYANOETHYL) DIISOPROPYLPHOSPHORAMIDITE
  • 2'-氟-DU CEP
  • 2'-脱氧-5'-DMT-2'- 氟尿苷-3-CE-亚磷酰胺
  • 氟代RU
  • 2,3-异丙叉-D-呋喃核糖
  • DMT-2′-氟-DU酰胺
  • 2-F-RU亚磷酰胺单体
  • 2'-F-DU 亚磷酰胺单体
  • 5'-O-(4,4-二甲氧基三苯甲基)-2'-脱氧-2'-氟尿苷-3'-(2-氰基乙基-N,N-二异丙基)亚磷酰胺
  • 146954-75-8
  • DMT-2′Fluoro-dU Phosphoramidite, 10 mM in DMSO
  • Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
  • DMT-2'FLUORO-DU PHOSPHORAMIDITE
  • 5'-O-DMT-2'-fluoro-2'-Deoxyuridine 3'-CE phosphoramidite
  • 2'-F-5'-O-DMT-2'-dU-3'-CE-Phosphoramidite
  • 2'-Fluoro-2'-deoxy Uridine CED Phosphoramidite
  • DMT-2'-F-dU-CE Phosphoramidite
  • 2'-F-U Phosphoramidite
  • 5'-ODMT-2'-Fluoro uridine-3'-OCEPA
  • 5'-O-(4, 4'-dimethoxytrityl)-2'-fluoro-2'-deoxyuridine-3'-CE-Phosphoramidite
  • 2’-F-dU Amidite
  • DMTr-2'-F-dU-3'-CE-Phosphoramidite
  • 3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-tetrahydrofuran-3-yl]oxy-(diisopropylamino)phosphanyl]oxypropanenitrile
  • 2'-Fluoro Uridine Amidite
  • 5'-O-DMT-2'-F-2'-Deoxy Uridine -3’-Cyanoethyl Phosphoramidite
  • Inhibitor,Nucleoside Antimetabolite/Analog,DMT2′FluorodU Phosphoramidite,inhibit,DMT 2′Fluoro dU Phosphoramidite
  • 5'-O-DMT-2'-fluoro-dU-CE
  • DMT-2’-F-dU-CE Phosphoramidite
  • DMT-2'-F-U Phosphoramidite
  • 2‘-F-U amidite

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