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Doxifluridine

Doxifluridine Property

Safety

Hazard Codes :Xi
Risk Statements :36/37/38
Safety Statements :26-36-24/25
WGK Germany :2
RTECS :YU7526000
Hazard Note :Irritant
HazardClass :IRRITANT, IRRITANT-HARMFUL
HS Code :29349990
Toxicity :LD50 (14 day) in mice or rats (mg/kg): >1000 i.v.: >2000 s.c.; in male, female mice, male, female rats (mg/kg): >5000, >5000, 3471, 3390 orally (Shimizu)

NFPA 704:

Hazard and Precautionary Statements (GHS)

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Doxifluridine Chemical Properties,Usage,Production

Description Doxifluridine is a prodrug derivative of 5-fluorouracil (5-FU). As an antineoplastic it is more potent than 5-FU in the treatment of breast, stomach, colon and rectal cancers.
Chemical Properties White Solid
Originator Hoffmann-LaRoche (USA)
Uses antineoplastic, pyrimidine antimetabolite
Uses A prodrug of 5-Flurouridine. A fluorinated pyrimidine nucleoside with cytostatic activity
Uses An antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes. A metabolite of Capecitabine
Uses 5’-Deoxy-5-fluorouridine is a metabolite of the chemotherapeutic agent Capecitabine (C175650). 5’-Deoxy-5-fluorouridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts tranformed by H-ras or trk oncogenes.
Definition ChEBI: A pyrimidine 5'-deoxyribonucleoside that is 5-fluorouridine in which the hydroxy group at the 5' position is replaced by a hydrogen. It is an oral prodrug of the antineoplastic agent 5-fluorouracil. Designed to circumvent the rapid degradation of 5-fluoro racil by dihydropyrimidine dehydrogenase in the gut wall, it is converted into 5-fluorouracil in the presence of pyrimidine nucleoside phosphorylase.
brand name Furtulon
Biochem/physiol Actions Doxifluridine is an antitumor agent efficient in tumors, cell lines or in fibroblasts transformed by H-ras or trk oncogenes. Possesses anticachectic activity which is independent of its antiproliferative activity.

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Doxifluridine Spectrum

3094-09-5, DoxifluridineRelated Search:

Nucleosides, Nucleotides & Related Reagents
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FURTULON
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C9H11FN2O5
3094/9/5
3094-90-5
3094-9-5
3094-09-05
3094-009-5
5-氟-5'-脱氧尿苷(5-F-5'-DU)
5'-脱氧-5-氟尿苷, 胸腺嘧啶酸合成酶抑制剂
5-氟-5'-脱氧尿苷(5-F-5'-DU)
5'-脱氧-5'-氟尿苷
5'-脱氧-5-氟尿苷
卡培他滨杂质16(卡培他滨EP杂质B)
去氧氟尿苷(卡培他滨EP杂质B)
标准品对照品】DOXIFLURIDINE