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t-Boc-N-amido-PEG2-NHS ester

t-Boc-N-amido-PEG2-NHS ester Structure
t-Boc-N-amido-PEG2-NHS ester
  • CAS No.2183440-73-3
  • Chemical Name:t-Boc-N-amido-PEG2-NHS ester
  • CBNumber:CB84849669
  • Molecular Formula:C16H26N2O8
  • Formula Weight:374.39
  • MOL File:2183440-73-3.mol
t-Boc-N-amido-PEG2-NHS ester Property
  • Density 1.24±0.1 g/cm3(Predicted)
  • solubility Soluble in DCM
  • pka 12.22±0.46(Predicted)
  • form Solid
  • color White to off-white
  • InChI InChI=1S/C16H26N2O8/c1-16(2,3)25-15(22)17-7-9-24-11-10-23-8-6-14(21)26-18-12(19)4-5-13(18)20/h4-11H2,1-3H3,(H,17,22)
  • InChIKey FNZXIPYAXFROBS-UHFFFAOYSA-N
  • SMILES C(ON1C(=O)CCC1=O)(=O)CCOCCOCCNC(=O)OC(C)(C)C
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319
  • Precautionary statements P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

t-Boc-N-amido-PEG2-NHS ester Chemical Properties,Usage,Production

  • Description t-Boc-N-amido-PEG2-NHS ester is a PEG linker containing an NHS ester and a t-Boc protected amine group. The hydrophilic PEG spacer increases the solubility of compounds in aqueous media. The t-Boc group can be deprotected under mild acidic conditions to form a free amine. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.
  • Uses Boc-NH-PEG2-C2-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
  • IC 50 Alkyl/ether
  • References [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
t-Boc-N-amido-PEG2-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
t-Boc-N-amido-PEG2-NHS ester Suppliers
Global(30)Suppliers
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    TargetMol Chemicals Inc.
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t-Boc-N-amido-PEG2-NHS ester Spectrum
2183440-73-3, t-Boc-N-amido-PEG2-NHS esterRelated Search:
  • 抑制剂
  • PEG系列产品-Boc-PEG系列
  • 助剂
  • 化合物 BOC-NH-PEG2-C2-NHS ESTER
  • T-BOC-N-酰胺-二聚乙二醇-活性酯
  • 叔丁氧羰基-PEG2-琥珀酰亚胺酯
  • 2,5-二氧代吡咯烷-1-基 2,2-二甲基-4-氧代-3,8,11-三氧杂-5-氮杂十四烷-14-酸酯
  • 氨基叔丁酯-二聚乙二醇-琥珀酰亚胺酯
  • 氨基叔丁酯-二聚乙二醇-NHS 酯
  • 2183440-73-3
  • (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethoxy]ethoxy]propanoate
  • BocNH-PEG2-CH2CH2COONHS/4,7,12-Trioxa-10-azatetradecanoic acid, 13,13-dimethyl-11-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
  • BocNH-PEG2-CH2CH2COONHS
  • 2,5-Dioxopyrrolidin-1-yl 2,2-dimethyl-4-oxo-3,8,11-trioxa-5-azatetradecan-14-oate
  • 4,7,12-Trioxa-10-azatetradecanoic acid, 13,13-dimethyl-11-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
  • Boc-NH-PEG2-C2-NHS ester
  • t-Boc-N-amido-PEG2-NHS ester

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