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t-Boc-N-Amido-PEG2-Propargyl

t-Boc-N-Amido-PEG2-Propargyl Structure
t-Boc-N-Amido-PEG2-Propargyl
  • CAS No.869310-84-9
  • Chemical Name:t-Boc-N-Amido-PEG2-Propargyl
  • CBNumber:CB73364012
  • Molecular Formula:C12H21NO4
  • Formula Weight:243.3
  • MOL File:869310-84-9.mol
t-Boc-N-Amido-PEG2-Propargyl Property
  • Boiling point 344.2±27.0 °C(Predicted)
  • Density 1.033±0.06 g/cm3(Predicted)
  • form Liquid
  • pka 12.22±0.46(Predicted)
  • color Colorless to light yellow
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H302-H312-H332
  • Precautionary statements P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P330-P363-P501

t-Boc-N-Amido-PEG2-Propargyl Chemical Properties,Usage,Production

  • Description t-Boc-N-Amido-PEG2-propargyl is crosslinker consisting of a propargyl group and a t-Boc protected amine group. The propargyl group reacts with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The t-Boc protected amine can be deprotected under mild acidic conditions.
  • Uses Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHBoc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • IC 50 Cleavable Linker; PEGs; Alkyl/ether
  • References [1] Nello Mainolfi, et al. rak degraders and uses thereof. US20190192668A1.
t-Boc-N-Amido-PEG2-Propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
t-Boc-N-Amido-PEG2-Propargyl Suppliers
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t-Boc-N-Amido-PEG2-Propargyl Spectrum
869310-84-9, t-Boc-N-Amido-PEG2-PropargylRelated Search:
  • 抑制剂
  • PEG系列产品-Propargy-PEG系列
  • 化合物 PROPARGYL-PEG2-NHBOC
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  • 叔丁氧羰基-PEG2-丙炔
  • (2-(2-(丙-2-炔-1-基氧基)乙氧基)乙基)氨基甲酸叔丁酯
  • 丙炔-二聚乙二醇-氨基叔丁酯
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  • (2-(2-(2-丙炔基-1-氧基)乙氧基)乙基)氨基甲酸叔丁酯
  • 869310-84-9
  • Carbamic acid, N-[2-[2-(2-propyn-1-yloxy)ethoxy]ethyl]-, 1,1-dimethylethyl ester
  • tert-butyl N-[2-(2-prop-2-ynoxyethoxy)ethyl]carbamate
  • Propargyl-PEG3-Boc Amine
  • N-Boc-2-[2-(2-propyn-1-yloxy)ethoxy]ethanamine
  • Propargyl-PEG2-NHBoc
  • t-Boc-N-Amido-PEG2-Propargyl
  • tert-butyl (2-(2-(prop-2-yn-1-yloxy)ethoxy)ethyl)carbamate

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