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Teprenone

Teprenone Structure
Teprenone
  • CAS No.6809-52-5
  • Chemical Name:Teprenone
  • CBNumber:CB8386175
  • Molecular Formula:C23H38O
  • Formula Weight:330.55
  • MOL File:6809-52-5.mol
Teprenone Property
  • Boiling point bp0.01 155-160°
  • Density d420.5 0.9081
  • refractive index nD20 1.4947
  • storage temp. -20°C
  • solubility DMSO: >5mg/mL
  • form liquid
  • color clear
  • Merck 14,9228
  • Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
  • InChIKey SBOCYPUKNYDTSX-DMLVRTFPSA-N
  • LogP 8.200 (est)
  • CAS DataBase Reference 6809-52-5(CAS DataBase Reference)
  • FDA UNII S8S8451A4O
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
  • WGK Germany  :3
  • RTECS  :RA5391300
  • HS Code  :2914.19.0000
  • NFPA 704:
    3
    2 0
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H315-H319-H335
  • Precautionary statements P261-P305+P351+P338
Teprenone Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: G5048
  • Product name : Geranylgeranylacetone
  • Purity: 
  • Packaging: 10MG
  • Price: ₹8746.6
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: G5048
  • Product name : Geranylgeranylacetone
  • Purity: 
  • Packaging: 50MG
  • Price: ₹35062.18
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: T2701
  • Product name : Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers]
  • Purity: min. 95.0 %(total of isomer)
  • Packaging: 1G
  • Price: ₹9100
  • Updated: 2022/05/26
  • Buy: Buy
  • Brand: TCI Chemicals (India)
  • Product number: T2701
  • Product name : Teprenone [mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers]
  • Purity: min. 95.0 %(total of isomer)
  • Packaging: 5G
  • Price: ₹14500
  • Updated: 2022/05/26
  • Buy: Buy

Teprenone Chemical Properties,Usage,Production

  • Description Teprenone (geranylgeranylacetone) is an antiulcer agent whose synthesis was inspired by the gastric protecting properties of Coenzyme Q10. Teprenone is reported to act via enhancement of gastric mucosal glycoprotein secretion.
  • Description Geranylgeranylacetone is an inducer of heat shock protein (Hsp) expression that has been shown to increase Hsp70 (also known as Hsp72 and HspA1A), Hsp22 (HspB8), Hsp27 (HspB1), Hsp90 (HspC), and Hsp105 (HspH1) levels in various cells and tissues. It is orally bioavailable and has diverse effects in vivo, including hepatoprotective, neuroprotective, and antiulcerative effects. The effects of geranylgeranylacetone on Hsp expression are more pronounced under stress conditions.
  • Chemical Properties Yellow Oil
  • Originator Eisai (Japan)
  • Uses An anti-ulcerative. Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.
  • Uses Geranylgeranylacetone has been used as an inducer of heat shock protein 70 (HSP70) to analyze its protective effects against cerebral ischemia/reperfusion (I/R).
  • Definition ChEBI: A terpene ketone in which a (9E,13E)-geranylgernayl group is bonded to one of the alpha-methyls of acetone (it is a mixture of 5E- and 5Z-geoisomers in a 3:2 ratio).
  • brand name SELBEX
  • Biochem/physiol Actions Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.
  • References 1) Kamal and Omran (2013) The role of heat shock protein 70 induced by geranylgeranylacetone in carbon tetrachloride-exposed adult rat testes; Pathophysiology, 20 139 2) Lennikov et al. (2013) Induction of heat chock protein 70 ameliorates ultraviolet-induced photokeratitis in mice; Int. J. Mol. Sci., 14 2175 3) Adache et al. (2010) An acyclic polyisoprenoid derivative, geranylgeranylacetone, protects against visceral adiposity and insulin resistance in high fat fed mice; Am. J. Physiol. Endocrinol. Metab., 299 E764 4) Marunouchi et al. (2014) Protective effect of geranylgeranylacetone via enhanced induction of HSPB1 and HSPB8 in mitochondria of the failing heart following myocardial infarction in rats; Eur. J. Pharmacol. 730 140
Teprenone Preparation Products And Raw materials
Raw materials
Preparation Products
Teprenone Suppliers
Global(214)Suppliers
  • Supplier：
    Henan Fengda Chemical Co., Ltd
  • Tel：+86-371-86557731<br/>+86-13613820652
  • Email：info@fdachem.com
  • Country：China
  • ProdList：20235
  • Advantage：58
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：factory@coreychem.com
  • Country：China
  • ProdList：29808
  • Advantage：58
  • Supplier：
    TargetMol Chemicals Inc.
  • Tel：+1-781-999-5354<br/>+1-00000000000
  • Email：marketing@targetmol.com
  • Country：United States
  • ProdList：32159
  • Advantage：58

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Teprenone Spectrum
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  • 医药中间体
  • 2C23H38O
  • 替普瑞酮,10 MM DMSO 溶液
  • TEPRENONE (GERANYLGERANYLACETONE),HSP70,HSPB8,AND HSPB1 EXPRESSION INDUCER
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  • 替普瑞酮(干冰运输)
  • 6,10,14,18-四甲基-5,9,13,17-十九碳四烯-2-酮
  • 替普瑞酮(异构体混合物)
  • 6,10,14,18-四甲基-5,9,13,17-十九碳四烯-2-酮
  • 替普瑞酮
  • 戊四烯酮
  • 替普瑞酮[(5E,9E,13E)- 和(5Z,9E,13E)异构体混和物]
  • 6809-52-5
  • Teprenone, 10 mM in DMSO
  • Teprenone (Geranylgeranylacetone), HSP70, HSPB8, and HSPB1 expression inducer
  • Tepronone
  • Teprenone, mixture of (5E,9E,13E)- and (5Z,9E,13E)- isomers，≥ 95.0%
  • Teprenone（Z/Emixture）
  • eprenone
  • geranylgeranylacetone
  • NanoLiposomal Teprenone , Water-Soluble Teprenone
  • TeprenoneQ: What is Teprenone Q: What is the CAS Number of Teprenone Q: What is the storage condition of Teprenone Q: What are the applications of Teprenone
  • 6,10,14,18-Tetramethylnonadeca-5,9,13,17-tetraen-2-one
  • Teprenone USP/EP/BP
  • Teprenone RS
  • (5Z,9Z,13Z)-6,10,14,18-tetramethyl-2-nonadeca-5,9,13,17-tetraenone
  • All trans-Teprenone
  • Teprenone (trans,trans)
  • Teprenone, >=98%
  • UNII-S8S8451A4O
  • 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one, mixture of (5E,9E,13E) and (5Z,9E,13E) isomers
  • 5,9,13,17-Nonadecatetraen-2-one,6,10,14,18-tetraMethyl-
  • Geranylgeranylacetone 6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one
  • 6,10,14,18-TetraMethyl-

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