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Androstenedione

Biological Metabolism

Androstenedione

CAS No.63-05-8
Chemical Name:Androstenedione
CBNumber:CB8365581
Molecular Formula:C19H26O2
Formula Weight:286.41
MOL File:63-05-8.mol

Androstenedione Property

Melting point 170-171 °C(lit.)
alpha D30 +199° (in chloroform)
Boiling point 368.77°C (rough estimate)
Density 1.0655 (rough estimate)
refractive index 1.4709 (estimate)
Flash point 2℃
storage temp. Controlled Substance, -20°C Freezer
solubility Chloroform (Slightly), Ethanol (Slightly, Sonicated), Methanol (Sparingly)
form Solid
color Dimorphous: Needles from acetone, or crystalsfrom hexane
Water Solubility 57.28mg/L(25 ºC)
Merck 13,643
InChIKey AEMFNILZOJDQLW-QAGGRKNESA-N
CAS DataBase Reference 63-05-8(CAS DataBase Reference)
FDA UNII 409J2J96VR
Proposition 65 List Androstenedione
NIST Chemistry Reference Androst-4-ene-3,17-dione(63-05-8)
EPA Substance Registry System 4-Androstenedione (63-05-8)
UNSPSC Code 41116107
NACRES NA.24

Safety

Hazard Codes :Xn,T,F
Risk Statements :40-64-52-22-61-60-36-20/21/22-11
Safety Statements :22-24/25-36-45-36/37-53-26-16
RIDADR :UN 1648 3 / PGII
WGK Germany :3
RTECS :BV8150000
HS Code :29372900
Hazardous Substances Data :63-05-8(Hazardous Substances Data)

NFPA 704:

	1
2		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H225-H302+H312+H332-H319
Precautionary statements P210-P261-P280-P305+P351+P338-P370+P378-P403+P235

Androstenedione Price More Price(1)

Brand: Sigma-Aldrich(India)
Product number: A-075
Product name : Androstenedione solution
Purity: 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1ML
Price: ₹5200.3
Updated: 2022/06/14
Buy: Buy

Androstenedione Chemical Properties,Usage,Production

Biological Metabolism The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Description Androstenedione (CRM) (Item No. ISO60161) is a certified reference material categorized as an anabolic androgenic steroid. Androstenedione is a precursor of testosterone (Item Nos. ISO60154 | ISO00154 | 15645) and estrone . Androstenedione is regulated as a Schedule III compound in the United States. Androstenedione (CRM) (Item No. ISO60161) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Chemical Properties White to Off-White Solid
Uses Testosterone precursor and metabolite with androgenic activity. Controlled substance (anabolic sterid)
Definition ChEBI: A 3-oxo Delta4-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.
Safety Profile An experimental teratogen. Otherexperimental reproductive effects. Questionablecarcinogen with experimental tumorigenic data. Whenheated to decomposition it emits acrid smoke andirritating fumes.
Purification Methods Crystallise the dione from hexane. It is soluble in *C6H6, CHCl3 and EtOH. It has max at 239nm. It is a precursor of estrone or testosterone and has androgenic activity. [Ruzicka & Wettstein Helv Chim Acta 18 980 1935, Beilstein 7 III 3636, 7 IV 2381.]
Toxics Screening Level The initial threshold screening level (ITSL) for androstenedione is 17 μg/m3 based on an annual averaging time.