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Zearalenone

CAS No.17924-92-4
Chemical Name:Zearalenone
CBNumber:CB4131407
Molecular Formula:C18H22O5
Formula Weight:318.36
MOL File:17924-92-4.mol

Zearalenone Property

Melting point 164-165°C
alpha 25546 -170.5° (c = 1.0 in CH3OH)
Boiling point 377.53°C (rough estimate)
Density 1.1270 (rough estimate)
refractive index 1.6120 (estimate)
Flash point 6 °C
storage temp. 2-8°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml; Ethanol: 20 mg/ml
pka 7.58±0.40(Predicted)
form Solid
color Off-white
Merck 13,10169
BRN 1350216
InChIKey MBMQEIFVQACCCH-QBODLPLBSA-N
LogP 3.830 (est)
CAS DataBase Reference 17924-92-4(CAS DataBase Reference)
FDA UNII 5W827M159J
EPA Substance Registry System Zearalenone (17924-92-4)
UNSPSC Code 85151701
NACRES NA.77

Safety

Hazard Codes :C,Xn,F
Risk Statements :34-62-63-36-20/21/22-11
Safety Statements :26-36/37/39-45-36-16-36/37
RIDADR :UN 3261 8/PG 2
WGK Germany :3
RTECS :DM2550000
F :10
HS Code :29322090
Hazardous Substances Data :17924-92-4(Hazardous Substances Data)

NFPA 704:

	0
3		0

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal wordDanger
Hazard statements H314-H361d
Precautionary statements P202-P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338

Zearalenone Price More Price(5)

Brand: Sigma-Aldrich(India)
Product number: Z2125
Product name : Zearalenone
Purity: fungal mycotoxin
Packaging: 10MG
Price: ₹17081.85
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: Z2125
Product name : Zearalenone
Purity: fungal mycotoxin
Packaging: 25MG
Price: ₹27419.73
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: CRM46916
Product name : Zearalenone solution
Purity: certified reference material, 50?μg/mL in acetonitrile, ampule of 1?mL
Packaging: 1ML
Price: ₹9389.8
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 34126
Product name : Zearalenone solution
Purity: 100?μg/mL in acetonitrile, analytical standard
Packaging: 2ML
Price: ₹36269.1
Updated: 2022/06/14
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Brand: Sigma-Aldrich(India)
Product number: 32939
Product name : Zearalenone
Purity: reference material
Packaging: 5MG
Price: ₹58390.05
Updated: 2022/06/14
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Zearalenone Chemical Properties,Usage,Production

Chemical Properties Crystalline Solid
Uses A phytoestrogenic mycotoxin and ER activator
Uses Estrogenic mycotoxin produced by Fusarium fungi commonly found in grains. One of a group of compounds known as resorcylic acid lactones
Uses Zearalenone is a resorcylic acid lactone produced by a number of Fusarium sp.. Zearalenone acts as a non-steroidal estrogen, binding to estrogen receptor and is uterotropic. Zearalenone induces reproductive problems in animals and, in some animal models, is thought to be a primary initiator of hepatic tumours. In vivo, zearalenone undergoes metabolic reduction to the more estrogenic zearalenol. Contamination of grains, notably maize, by Fusarium species gives rise to high levels of zearalenone and is regarded as an important food quality issue for both humans and animal health.
Definition ChEBI: A macrolide comprising a fourteen-membered lactone fused to 1,3-dihydroxybenzene; a potent estrogenic metabolite produced by some Giberella species.
General Description White microcrystals or white powder.
Air & Water Reactions Zearalenone may be sensitive to prolonged exposure to air. Insoluble in water.
Reactivity Profile Zearalenone is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. Zearalenone may be incompatible with alkalis.
Fire Hazard Flash point data for Zearalenone are not available. Zearalenone is probably combustible.
Biochem/physiol Actions Zearalenone, a fungal mycotoxin produced by Fusarium, binds the estrogen receptor (ER) and is uterotropic in the newborn rat. It is a common contaminant in cereal grain used for animal and human food, and exerts an estrogenic activity that modulates/disrupts endocrine function in animals and possibly humans.
Metabolic pathway When zearalenone is subjected to microbial transformation by a fungus, Gliocladium roseum, it is converted to a 1 : 1 mixture of 1-(3,5-dihydroxyphenyl)- 10 0 -hydroxy-1-undecen-6'-one and 1-(3,5- dihydroxyphenyl)-6'-hydroxy-1-undecen-10'-one.
storage -20°C