ChemicalBook > CAS DataBase List > Norepinephrine

Norepinephrine

Norepinephrine Structure
Norepinephrine
  • CAS No.51-41-2
  • Chemical Name:Norepinephrine
  • CBNumber:CB8346810
  • Molecular Formula:C8H11NO3
  • Formula Weight:169.18
  • MOL File:51-41-2.mol
Norepinephrine Property
  • Melting point 220-230°C
  • alpha D25 -37.3° (c = 5 in water with 1 equiv HCl)
  • Boiling point 298.46°C (rough estimate)
  • Density 1.2435 (rough estimate)
  • refractive index 1.5100 (estimate)
  • storage temp. 2-8°C
  • solubility Aqueous Acid (Slightly), DMSO (Slightly)
  • pka 8.64(at 25℃)
  • form crystalline
  • color off-white to tan
  • optical activity D +37.426 (c 5, H2O+HCl)L -37.1325 (c 5, H2O+HCl)
  • Water Solubility Soluble in alkali and dilute hydrochloric acid. Slightly soluble in water, ethanol and diethyl ether.
  • Sensitive Air & Light Sensitive
  • Merck 14,6695
  • BRN 4231961
  • Stability Stable, but may be light-sensitive. Incompatible with acids, bases, oxidizing agents. Store at -20℃.
  • CAS DataBase Reference 51-41-2(CAS DataBase Reference)
  • NCI Dictionary of Cancer Terms noradrenaline; norepinephrine
  • FDA UNII X4W3ENH1CV
  • NCI Drug Dictionary norepinephrine
  • ATC code C01CA03
  • EPA Substance Registry System Norepinephrine (51-41-2)
  • UNSPSC Code 12352200
  • NACRES NA.77
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordDanger
  • Hazard statements H300+H310+H330
  • Precautionary statements P260-P262-P264-P280-P302+P352+P310-P304+P340+P310
Norepinephrine Price More Price(4)
  • Brand: Sigma-Aldrich(India)
  • Product number: A7257
  • Product name : (−)-Norepinephrine
  • Purity: ≥98%, crystalline
  • Packaging: 500MG
  • Price: ₹22754.15
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: A7257
  • Product name : (−)-Norepinephrine
  • Purity: ≥98%, crystalline
  • Packaging: 1G
  • Price: ₹42195.85
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: Sigma-Aldrich(India)
  • Product number: A7257
  • Product name : (−)-Norepinephrine
  • Purity: ≥98%, crystalline
  • Packaging: 5G
  • Price: ₹151257.73
  • Updated: 2022/06/14
  • Buy: Buy
  • Brand: ALFA India
  • Product number: ALF-L08087-03
  • Product name : L-Noradrenaline, 98%
  • Purity: 
  • Packaging: 1g
  • Price: ₹40785
  • Updated: 2022/05/26
  • Buy: Buy

Norepinephrine Chemical Properties,Usage,Production

  • Chemical Properties solid
  • Uses An adrenergic neurotransmitter.
  • Uses Vascular active drug resistance to shock
  • Uses Norepinephrine is used for increasing cardiac constriction and for the necessary elevation of blood pressure after sharp decline, which can result from surgical intervention or trauma.
  • Definition ChEBI: The R-enantiomer of noradrenaline.
  • brand name Levophed (Hospira);Noradrec;Xylotox.
  • World Health Organization (WHO) Vasoconstrictor agents have been in use for many years to prolong duration of action of local anaesthetics, particularly in dentistry. Combination products containing epinephrine or levarterenol in concentrations of 1:80,000 or less remain widely available. See also WHO comment for epinephrine.
  • Biological Functions Most central noradrenergic neurons are located in the nucleus locus ceruleus of the pons and in neurons of the reticular formation. Fibers from these nuclei innervate a large number of cortical, subcortical, and spinomedullary fields. Many functions have been ascribed to the central noradrenergic neurons, including a role in affective disorders (see Chapter 33), in learning and memory, and in sleep–wake cycle regulation.The mammalian CNS contains both α- and β-adrenoceptors.
  • General Description Norepinephrine (NE, Levophed) differs from DA onlyby addition of a 1-OH substituent (β-OH-DA) and from Eonly by lacking the N-methyl group. Like DA, it is polar andrapidly metabolized by both COMT and MAO, resulting inpoor oral bioavailability and short DOA (1 or 2 minutes evenwhen given intravenously). It is a stimulant of α1-, α2-, andβ1-adrenoceptors (notice that lacking the N-methyl group resultsin lacking β2- and β3-activity). It is used to counteractvarious hypotensive crises, because its α-activity raisesblood pressure and as an adjunct treatment in cardiac arrestbecause its β-activity stimulates the heart. It has limitedclinical application caused by the nonselective nature of itsactivities.
  • Hazard May cause local tissue necrosis, headache, bradycardia, hypertension; poison; teratogen; mutagen.
  • Biochem/physiol Actions Adrenergic neurotransmitter
  • Pharmacology Norepinephrine is the primary neurotransmitter produced and released by adrenergic neurons, and in literature it is also described as and called () noradrenaline or levarterenol. This vasopressor catecholamine reduces both the resistance and capacity of blood vessels by stimulating α-adrenoreceptors and having a direct cardiostimulatory effect, which is accomplished by activation of β1-adrenoreceptors. Norepinephrine exhibits significantly less activity than epinephrine as a drug for widening blood vessels through the activation of β2-adrenoreceptors. Elevation of both stylistic and diastolic blood pressure is a typical reaction to intravenous introduction of norepinephrine.
  • Safety Profile Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. A sympathomimetic vasopressor. When heated to decomposition it emits toxic fumes of NOx.
  • Synthesis Norepinephrine, L-1-(3,4-dihydroxyphenyl)-2-aminoethanol (11.1.4), is synthesized by two methods starting from 3,4-dihydroxybenzaldehyde. According to the first method, the indicated aldehyde is transformed into the cyanohydrin (11.1.3) by reaction with hydrogen cyanide, which is then reduced into norepinephrine (11.1.5).
    Synthesis_51-41-2_1
    The second method consists of the condensation of diacetate of the same aldehyde with nitromethane, which forms (3,4-diacetoxyphenyl)-2-nitroethanol (11.1.5). Then the nitro group is reduced and the product (11.1.6) is hydrolyzed into the desired norepinephrine (11.1.4) [4,9,13,14].
    Synthesis_51-41-2_2
  • Purification Methods Recrystallise adrenor from EtOH and store it in the dark under N2. [pKa, Lewis Brit J Pharmacol Chemother 9 488 1954, UV: Bergstr.m et al. Acta Physiol Scand 20 101 1950, Fluorescence: Bowman et al. Science NY 122 32 1955, Tullar J Am Chem Soc 70 2067 1948.] The L-tartrate salt monohydrate has m 102-104.5o, [] D -11o (c 1.6, H2O), after recrystallisation from H2O or EtOH. [Beilstein 13 III 2382.]
Norepinephrine Preparation Products And Raw materials
Raw materials
Preparation Products
Norepinephrine Suppliers
Global(308)Suppliers
  • Supplier：
    Henan Tianfu Chemical Co.,Ltd.
  • Tel：+86-0371-55170693<br/>+86-19937530512
  • Email：info@tianfuchem.com
  • Country：China
  • ProdList：21628
  • Advantage：55
  • Supplier：
    career henan chemical co
  • Tel：+86-0371-86658258<br/>+8613203830695
  • Email：sales@coreychem.com
  • Country：China
  • ProdList：29859
  • Advantage：58
  • Supplier：
    Standardpharm Co. Ltd.
  • Tel：86-714-3992388
  • Email：overseasales1@yongstandards.com
  • Country：United States
  • ProdList：14332
  • Advantage：58

Related articles

Norepinephrine Spectrum
51-41-2, NorepinephrineRelated Search:
  • chiral
  • 抑制剂
  • 药靶配体
  • 杂质对照品
  • 化学试剂
  • 出口原料
  • 原料
  • 原料药
  • 医用原料
  • α受体激动药
  • 医用原料
  • 原料药
  • 医药原料药
  • 细胞信号和神经生物学
  • 医药原料
  • 细胞生物学
  • C8H11NO3
  • 62697-73-9
  • 去甲肾上腺素检测标准品
  • 甲醇中去甲肾上腺素溶液
  • D-去加肾上腺素
  • 甲醇中去甲肾上腺素标准溶液
  • 肾上腺素EP杂质 B(去甲肾上腺素)
  • 标准品对照品】NOREPINEPHRINE
  • 卡罗磺钠杂质22
  • 肾上腺素/肾上腺素B
  • 去甲肾上腺素04
  • 3-苯并恶二唑-4-氨基)-2-脱氧-D-葡萄糖
  • 2-(N-7-硝基-2
  • L-去甲肾上腺素对照品
  • (R)-去甲肾上腺素,L-去甲肾上腺素
  • -去甲肾上腺素
  • 去甲肾上腺素,(R)-4-(2-氨基-1-羟基乙基)-1,2-苯二酚
  • L-去甲肾上腺激素
  • 去甲肾上腺素盐酸盐(溶液)[干冰运输]
  • NOREPINEPHRINE去甲肾上腺素
  • 4-[(1R)-2-氨基-1-羟乙基]苯-1,2-二醇
  • 肾上腺素杂质B
  • L-去甲肾上腺素, 98+%
  • 去甲肾上腺素(限制性化学品禁止进出口)
  • 去甲肾上腺素
  • (R)-4-(2-氨基-1-羟基乙基)-1,2-苯二酚
  • 51-41-2
  • Noradrenaline Impurity 35
  • Sodium carbalosulfonate impurity 22
  • Adrenaline EP Impurity B(Norepinephrine)
  • b .?(1R)-2-a mi no-1-(3,4-d i h yd roxyph e nyl)e th a nol (nora d re na li ne ),
  • (?)-Norepinephrine
  • NORADRENALINE
  • NORADRENALIN
  • L-NORADRENALINE
  • norartrinal
  • levophed
  • levoarterenol
  • arterenolfreebase(noradrenaline)
  • aktamin
  • adrenor
  • Norepinephrine Hydrochloride (Solution)

Home

My